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INVESTIGATION OF STAT5A (show STAT5A Proteins), FSHR AND LHR (show LHCGR Proteins) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The expression of FSHR mRNA in granulosa cells was highest in small antral follicles, then decreased significantly as follicles increased in size, and was lowest in cysts.
transfer. We conclude that variation at these loci of the FSHR gene has no significant effect on pregnancy rates in Luxi cattle.
Specific alleles of the bovine FSHR gene are associated with variations in embryo yield and in the number of unfertilised oocytes.
This study evaluated the relationships among aromatase (show CYP19A1 Proteins), IGF-1 (show IGF1 Proteins), IGF2R (show IGF2R Proteins), and follicle stimulating hormone (FSH) receptor levels expressed in ovarian follicles of cattle selected for twin pregnancies.
granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r (show IGF1R Proteins), and p450 arom (show CYP19A1 Proteins) expression, and precedes induction and subsequent peak E2 production
Dominant follicles experience a reduction in FSH (show BRD2 Proteins) dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR (show LHCGR Proteins)) as they grow during the low FSH (show BRD2 Proteins) milieu of follicular waves.
FSHR is specifically regulated through androgen receptor (show AR Proteins) in granulosa cells
Heterozygous heifers showed a higher pregnancy rate (67 and 66% for LHR (show LHCGR Proteins) and FSHR genes, respectively), but no significant effects were observed for the genes studied (
Data show that double mutation of follicle-stimulating hormone receptor (fshr) and luteinizing hormone receptor (lhcgr (show LHCGR Proteins)) resulted in infertile males.
Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr and lhcgr (show LHCGR Proteins).
Characterization of the first functional zebrafish (Danio rerio) gonadotropic hormone I receptor (follicle stimulating hormone receptor).
N680S FSHR gene polymorphism affects the efficacy of recombinant versus highly purified follicle-stimulating hormone.
The results of this study demonstrate that the genetic combination of A/G for polymorphism c.2039 with G/G for polymorphism c.-29 of the FSHR gene is significantly associated with the highest number of collected oocytes (p = 0.03). This association was significant even after controlling for the effect of other clinical variables
genetic association studies in peripubertal girls in Denmark: Data suggest that an SNP in FSHR (follicle stimulating hormone receptor, c.2039A>G) is associated with blood levels of FSH (show BRD2 Proteins), LH, and estradiol; minor alleles in FSHB (follicle stimulating hormone beta subunit (show FSHB Proteins), c.-211G>T) and FSHR (c.-29G>A) are associated with delayed pubertal onset.
results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1 (show CYP19A1 Proteins), FSHR, ESR1 (show ESR1 Proteins) and NRIP1 (show NRIP1 Proteins).
Data suggest that both sisters exhibiting primary ovarian failure are homozygous for a previously unreported missense mutation (c.1222G.T, p.Asp408Tyr) in the second transmembrane domain of FSHR; consanguinity in this Turkish family was reported. [CASE REPORT]
The luteinizing hormone/human chorionic gonadotrophin receptor (LHCGR (show LHCGR Proteins)) variant N312S and the follicle-stimulating hormone receptor (FSHR) variant N680S can be utilized for the prediction of pregnancy chances in women undergoing IVF (show SCN5A Proteins).
The role of FSHR gene variants (SNPs in exon 10 (codon 307 and 680) and in the core promoter region (at position -29) and Ala189Val inactivating mutation) in Turkish infertile women
Ala307Thr polymorphism in FSHR can be potentially associated to primary ovarian insufficiency development and can be considered as a screening marker in patients with ovarian failure signals.
The Asn680Ser polymorphism within the FSHR gene was not associated with endometriosis and infertility.
Our studies further confirmed reports that there were no significant associations between the FSHR Thr307Ala and Asn680Ser polymorphisms and male infertility risk. However, a combined FSHR genotype showed significant association with male infertility.
FSHR and LHR (show LHCGR Proteins) proteins are significantly upregulated in CCs (show CCS Proteins) surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence.
Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1 (show ESR1 Proteins), LHR (show LHCGR Proteins), and FSHR
Brca1 (show BRCA1 Proteins)(GC-/-) models reveal that specific intra-follicular Brca1 (show BRCA1 Proteins) loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 Proteins) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.
Data (including date from knockout mice) suggest that Fshr is expressed early in pregnany in placenta and other extragonadal tissues of fetoplacental unit; expression is particularly strong at term.
Sertoli cell-specific expression of MTA2 (show MTA2 Proteins) is required for transcriptional regulation of FSHR gene during spermatogenesis.
By day 20 and in adult animals total AR or FSHR ablation significantly reduced Leydig cell numbers but Sertoli cell specific AR ablation had no effect.
The results demonstrate that gain-of-function mutations of the FSHR in mice bring about distinct and clear changes in ovarian function
haploinsufficiency of the follicle-stimulating hormone receptor accelerates oocyte loss inducing early reproductive senescence and biological aging in mice
show that FSH-R haploinsufficiency leads to a decrease in ovulation, altered ovarian steroidogenesis, and neuroendocrine impairments resulting in early reproductive senescence
the loss of FSH-R signaling alters the follicular environment, where oocyte-granulosa interactions are perturbed, creating an out-of-phase germ cell and somatic cell development
The amount of dopamine d1 receptor (show DRD1 Proteins), dopamine D2 receptor (show DRD2 Proteins), and follicle stimulating hormone receptor (FSHr) mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.
The results showed that polymorphisms in exon 10 of the FSHR gene had a significant effect on litter size traits of Wannan Black and Berkshire pigs. These results can be applied for marker-assisted selection in the 2 swine breeds
These results showed that an increased FSHR gene expression level was accompanied with an increase in histone H3K9 acetylation levels, suggesting that histone H3K9 acetylation could regulate the expression of the porcine FSHR gene.
248 F(2) animals from a Duroc and Meishan cross were genotyped for three FSHR SNPs at positions 74, 532 and 1166, and these were correlated with the phenotypes of litter size and corpus luteum number
findings suggest the FSH receptor may be involved in the early follicle formation in pigs, which begins during prenatal life.
FSHR is expressed in the hamster ovary starting from the fetal life to account for FSH (show BRD2 Proteins)-induced primordial follicle formation and cyclic AMP (show TMPRSS5 Proteins) production.
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
follicle stimulating hormone receptor
, follicle-stimulating hormone receptor
, gonadotropic hormone I
, follicle-stimulating hormone receptor-like
, FSH receptor
, follitropin receptor