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Browse our anti-Histone Deacetylase 6 (HDAC6) Antibodies

Full name:
anti-Histone Deacetylase 6 Antibodies (HDAC6)
On are 251 Histone Deacetylase 6 (HDAC6) Antibodies from 32 different suppliers available. Additionally we are shipping Histone Deacetylase 6 Kits (18) and Histone Deacetylase 6 Proteins (17) and many more products for this protein. A total of 302 Histone Deacetylase 6 products are currently listed.
ATHDA6, AXE1, CG6170, dHDAC2, dHDAC6, Dmel\\CG6170, dmHDA404, DmHDAC2, DsimGD17207, dsim_GLEANR_17355, GD17207, Hd6, HDAC, HDAC2, Hdac5, HDAC6, histone deacetylase 6, MDC12.7, MDC12_7, MGC53140, mHDA2, RNA-MEDIATED TRANSCRIPTIONAL SILENCING 1, RPD3B, RTS1, Sfc6, SIL1, wu:fc31d02
list all antibodies Gene Name GeneID UniProt
HDAC6 10013 Q9UBN7
HDAC6 15185 Q9Z2V5
HDAC6 84581  

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Top referenced anti-Histone Deacetylase 6 Antibodies

  1. Human Polyclonal HDAC6 Primary Antibody for IHC (p), WB - ABIN387955 : Hook, Orian, Cowley, Eisenman: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 6 references for ABIN387955

  2. Human Polyclonal HDAC6 Primary Antibody for EIA, IHC (p) - ABIN356649 : Wolffe: Transcriptional control. Sinful repression. in Nature 1997 (PubMed)
    Show all 4 references for ABIN356649

  3. Human Polyclonal HDAC6 Primary Antibody for ChIP, WB - ABIN2668292 : Ying, Zhang, Zhou, Qu, Wang, Liu, Lu, Zhu: Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN2668292

  4. Human Polyclonal HDAC6 Primary Antibody for IHC, WB - ABIN223301 : Wang, Nguyen, McLaughlin, Sikkink, Ramirez-Alvarado, Weinshilboum: Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 3 references for ABIN223301

  5. Cow (Bovine) Polyclonal HDAC6 Primary Antibody for ChIP, IHC - ABIN2777306 : Voelter-Mahlknecht, Mahlknecht: Cloning and structural characterization of the human histone deacetylase 6 gene. in International journal of molecular medicine 2003 (PubMed)

More Antibodies against Histone Deacetylase 6 Interaction Partners

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 6 (HDAC6) interaction partners

  1. HDAC6 is necessary and sufficient for BRP (show GDF5 Antibodies) deacetylation. HDAC6 promotes the formation of larger presynaptic densities.

  2. Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin (show TUBA4A Antibodies) proteostasis and disruption of the cardiomyocyte microtubule structure.

  3. From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.

  4. Overexpressing any of HDAC 3 (show HDAC3 Antibodies), 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X (show FMR1 Antibodies) tremor ataxia (show USP14 Antibodies) syndrome.

  5. Data suggest that alpha-synuclein (show SNCA Antibodies) inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.

  6. findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy

  7. Findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy.

  8. Results suggest that atrophin recruits histone deacetylases 1 and 2 and G9a (show EHMT2 Antibodies) to modify histone H3K9 and to determine cell fates.

  9. Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.

Human Histone Deacetylase 6 (HDAC6) interaction partners

  1. The authors characterized the histone deacetylase 6-interacting proteins in LNCaP metastatic prostate cancer cells and found that histone deacetylase 6 interacts with proteins involved in several cellular processes, including autophagy.

  2. HDAC6 may represent an optimal target for future immunosuppressant therapeutics with a particular role in transplantation.

  3. a combination regimen of bortezomib and the histone deacetylase (show HDAC1 Antibodies) inhibitor trichostatin A abolished HDAC6 activity and decreased autophagy induction while significantly enhancing bortezomib-induced apoptosis in HNSCC cells.

  4. this review highlights current data illustrating the complexity and importance of HDAC6 in viral pathogenesis. [review]

  5. Systemic lupus erythematosus patients had higher methylation in the HDAC6 promoter and lower HDAC6 mRNA expression than the controls. These changes may be related to the susceptibility of SLE. However, they are not associated with the disease activity of SLE.

  6. Cutaneous T-cell lymphoma (CTCL (show TSPYL2 Antibodies)) pathogenesis remains unknown, and there are no curative therapies. Our findings not only demonstrate a critical role for IL15 (show IL15 Antibodies)-mediated inflammation in cutaneous T-cell lymphomagenesis, but also uncover a new oncogenic regulatory loop in CTCL (show TSPYL2 Antibodies) involving IL15 (show IL15 Antibodies), HDAC1 (show HDAC1 Antibodies), HDAC6, and miR (show MLXIP Antibodies)-21 that shows differential sensitivity to isotype-specific HDAC (show HDAC3 Antibodies) inhibitors

  7. HDAC6 confers resistance to vemurafenib in BRAF (show BRAF Antibodies)-mutant melanoma cells.

  8. The inhibition of HDAC6 may be a promising strategy for the treatment of lung adenocarcinoma.

  9. Data show that expressions of histone deacetylase 6 protein (HDAC6) and c-myc protein are increased in fibroblasts transformed with activated K-ras protein.

  10. Overexpression of HDAC6 confers non-small cell lung cancer resistance to sorafenib.

Mouse (Murine) Histone Deacetylase 6 (HDAC6) interaction partners

  1. Using a mouse model of Thanatophoric Dysplasia Type II (TDII) we show that both HDAC6 deletion and treatment with the small molecule HDAC6 inhibitor tubacin reduced FGFR3 (show FGFR3 Antibodies) accumulation in the growth plate and improved endochondral bone growth

  2. HDAC6 may represent an optimal target for future immunosuppressant therapeutics with a particular role in transplantation.

  3. Further PS treatment resulted in recovery of axonal outgrowth and enhanced retrograde axonal transport by decreasing histone deacetylase 6 (HDAC6) levels and thus increasing acetylation of alpha-tubulin (show TUBA4A Antibodies) levels. Thus, we have identified the molecular pathway that leads to neurodegeneration in FD and have demonstrated that phosphatidylserine treatment has the potential to slow progression of neurodegeneration

  4. HDAC6-mediated autophagy negatively regulates primary cilia length during silibinin treatment and has the potential to serve as a therapeutic target for primary cilia-associated ciliopathies.

  5. HDAC6 is an effector of the immune cytotoxic response that acts by affecting the dynamics, transport and secretion of lytic granules by cytotoxic T lymphocytes.

  6. It protects neurons from toxicity of prion (show PRNP Antibodies) peptide, and that this protection occurs at through the regulation of the PI3k-Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) axis.

  7. mass spectrometry-based quantitative comparison of acetylated peptides from wild-type vs HDAC6 knockout mice allowed to identify six new deacetylation sites possibly mediated by HDAC6.

  8. We therefore tested that reducing HDAC6 levels by genetic manipulation would attenuate early cognitive and behavioral deficits in R6/1 mice

  9. HDAC6 plays an important role in the function of CMA pathway under the HI stress induced by SCI and it may be a potential therapeutic target in acute SCI model.

  10. functional loss or suppression of the tumor suppressor HDAC6 is caused by induction of miR (show MLXIP Antibodies)-221 through coordinated JNK/c-Jun- and NF-kappaB (show NFKB1 Antibodies)-signaling pathways during liver tumorigenesis

Arabidopsis thaliana Histone Deacetylase 6 (HDAC6) interaction partners

  1. HDA6 is a component of the TRB2 (show TRIB2 Antibodies) complex.

  2. Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM

  3. HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation (show HELLS Antibodies) at CG dinucleotides.

  4. Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1 (show CD86 Antibodies)) in the root tip were affected in hda6 mutation.

  5. HDC1 is a ubiquitously expressed nuclear protein (show UBN1 Antibodies) that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.

  6. HDA6 and FLD (show LPIN1 Antibodies) could act together in a protein complex. Increased levels of histone H3 acetylation and H3K4 trimethylation, indicating functional interplay between histone deacetylase and demethylase (show MBD2 Antibodies) through HDA6 and FLD (show LPIN1 Antibodies) interaction in flowering control.

  7. Taken together, these data indicate that HDA6 is a part of the AS1 repressor complex to regulate the KNOX expression in leaf development.

  8. HD2C functionally associates with HDA6 and regulates gene expression through histone modifications.

  9. HDA6 and MET1 (show DNMT1 Antibodies) interact directly and act together to silence transposable elements by modulating DNA methylation (show HELLS Antibodies), histone acetylation, and histone methylation status.

  10. HDA6 and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.

Histone Deacetylase 6 (HDAC6) Antigen Profile

Antigen Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.

Alternative names and synonyms associated with Histone Deacetylase 6 (HDAC6)

  • CG6170 gene product from transcript CG6170-RA (HDAC6) antibody
  • histone deacetylase 6 (hdac6) antibody
  • DsimGD17207-PA (DsimHDAC6) antibody
  • histone deacetylase 6 (PTRG_03035) antibody
  • histone deacetylase 6 (HDAC6) antibody
  • histone deacetylase 6 (Hdac6) antibody
  • RPD3-like histone deacetylase (HDA6) antibody
  • ATHDA6 antibody
  • AXE1 antibody
  • CG6170 antibody
  • dHDAC2 antibody
  • dHDAC6 antibody
  • Dmel\\CG6170 antibody
  • dmHDA404 antibody
  • DmHDAC2 antibody
  • DsimGD17207 antibody
  • dsim_GLEANR_17355 antibody
  • GD17207 antibody
  • Hd6 antibody
  • HDAC antibody
  • HDAC2 antibody
  • Hdac5 antibody
  • HDAC6 antibody
  • histone deacetylase 6 antibody
  • MDC12.7 antibody
  • MDC12_7 antibody
  • MGC53140 antibody
  • mHDA2 antibody
  • RPD3B antibody
  • RTS1 antibody
  • Sfc6 antibody
  • SIL1 antibody
  • wu:fc31d02 antibody

Protein level used designations for HDAC6

CG6170-PA , CG6170-PB , CG6170-PC , CG6170-PD , CG6170-PE , CG6170-PF , CG6170-PG , HDAC6-PA , HDAC6-PB , HDAC6-PC , HDAC6-PD , HDAC6-PE , HDAC6-PF , HDAC6-PG , histone deacetylase 6 , histone deacetylase HDA2 , DsimGD17207-PA , DsimHDAC6-PA , GD17207-PA , HDAC6 , histone deacetylase 5 , histone deacetylase mHDA2 , scurfy candidate 6

32461 Drosophila melanogaster
380178 Xenopus laevis
565482 Danio rerio
6726010 Drosophila simulans
100379853 Xenopus (Silurana) tropicalis
6341259 Pyrenophora tritici-repentis Pt-1C-BFP
10013 Homo sapiens
15185 Mus musculus
84581 Rattus norvegicus
480907 Canis lupus familiaris
513602 Bos taurus
836431 Arabidopsis thaliana
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