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Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder.
compromising Tip60 histone acetyltransferase (show HAT ELISA Kits) activity in the CySC (show CST3 ELISA Kits) lineage recapitulates loss-of-function phenotypes of E(Pc), suggesting that Tip60 and E(Pc) act together, consistent with published biochemical data.
Heat Shock Factor recruits the dTip60 complex to the hsp70 loci in cells treated with salicylate, which triggers chromatin remodeling at these loci without transcription activation.
Excess Tip60 exerts a neuroprotective role in axonal transport and functional locomotion defects in an animal model of Alzheimer's disease.
a novel mechanism for Tip60 mediated sleep-wake regulation via control of axonal growth and PDF levels within the small ventrolateral neurons-encompassing neural network
a functional interaction between Tip60 and APP (show APP ELISA Kits) in mediating nervous system development and apoptotic neuronal cell death
The role of Tip60 HAT (show HAT ELISA Kits) activity in transcriptional control during multicellular development in vivo, was investigated.
Ubiquitous dTip60 knock-down in flies was lethal, whereas knock-down in the wing imaginal disk led to developmental defects.
demonstrated that the dTip60 chromatin-remodeling complex acetylates nucleosomal phospho-H2Av (show H2AFV ELISA Kits) and exchanges it with an unmodified H2Av (show H2AFV ELISA Kits); both the histone acetyltransferase (show HAT ELISA Kits) dTip60 and the atpase (show DNAH8 ELISA Kits) Domino/p400 catalyze the exchange of phospho-H2Av (show H2AFV ELISA Kits)
TIP60 complex can promote the generation of silent chromatin.
Collectively, the data establish a hitherto unknown liaison among MDR1, BMI1 (show BMI1 ELISA Kits) and TIP60 and provide mechanistic insights into cisplatin-induced MDR1 expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
TIP60-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT (show TERT ELISA Kits) repression through Sp1 (show PSG1 ELISA Kits) acetylation. In summary, our study has identified a novel substrate for TIP60 catalytic activity and a unique repressive mechanism acting at the TERT (show TERT ELISA Kits) promoter in virus-induced malignancies.
These findings reveal that Endoplasmic reticulum stress engages the GSK3beta (show GSK3b ELISA Kits)-TIP60-ULK1 (show ULK1 ELISA Kits) pathway to increase autophagy.
Methylation of RUVBL1 by the arginine methyltransferase PRMT5 (show PRMT5 ELISA Kits) is required for homologous recombination-mediated double-strand break repair by promoting TIP60-mediated histone H4K16 acetylation.
TIP60 complex regulates bivalent chromatin recognition/modification by 53BP1 (show TP53BP1 ELISA Kits) through direct H4K20me binding and H2AK15 acetylation.
Studies suggest that lysine (K) acetyltransferase inhibitors (KATi (show CCBL1 ELISA Kits)) are important for providing personalized therapies.
Thus Tip60 interacts with RNR and NME3 to provide site-specific synthesis of dNTP for facilitating DNA repair in serum-deprived cells which contain low levels of dNTPs.
TIP60 acted downstream of UHRF2 (show UHRF2 ELISA Kits) to regulate H3K9ac and H3K14ac expression.
Data provide evidence that the acetylation of H2AX (show H2AFX ELISA Kits) at Lys5 (show AASDHPPT ELISA Kits) by TIP60 is required for the (ADPribosyl) ation activity and the dynamic binding of PARP-1 (show PARP1 ELISA Kits) to chromatin after the induction of DNA damage.
Synthetic lethality screening identifies TIP60-dependent radiation sensitivity in the absence of BAF180 (show PBRM1 ELISA Kits).
Results report that EPC1 (show EPC1 ELISA Kits) and TIP60 are co-expressed in male germ cells. Genetic ablation of either Epc1 (show EPC1 ELISA Kits) or Tip60 disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development.
these results identify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might be dependent on BRD2 (show BRD2 ELISA Kits) recruitment by H4K12 acetylation.
The expression of putative SOX4 target genes during myoblast differentiation is specifically regulated by the molecular switching of the co-activator KAT5 and the co-repressor HDAC1 on SOX4 transcriptional activation.
TIP60 K327 acetylation allows TIP60 to switch binding partners. conditional knockout in Treg cells results in autoimmune disease.
Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo.
Tip60 hyperacetylates histone H4 in Ras-transformed cells.Tip60 coordinates histone acetylation at both local and global levels to facilitate Ras-induced transformation.
RGS6 (show RGS6 ELISA Kits) suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 (show DNMT1 ELISA Kits) degradation and promoting apoptosis
Early adipogenesis is regulated through USP7 (show USP7 ELISA Kits)-mediated deubiquitination of the histone acetyltransferase TIP60.
SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2 (show SYCE2 ELISA Kits)) and histone acetyltransferase TIP60.
these results suggest that Tip60 binds with Pax6 (show PAX6 ELISA Kits) and that this physical interaction leads to the full-transcriptional activation of Pax6 (show PAX6 ELISA Kits) during retina development.
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
K(lysine) acetyltransferase 5
, Tat-interactive protein
, histone acetyltransferase Tip60
, HIV-1 tat interactive protein
, 60 kDa Tat-interactive protein
, HIV-1 Tat interactive protein, 60kDa
, K-acetyltransferase 5
, Tat interacting protein, 60kDa
, cPLA(2)-interacting protein
, cPLA2 interacting protein
, histone acetyltransferase HTATIP
, histone acetyltransferase KAT5
, HIV-1 tat interactive protein 1, 60 kDa homolog
, HIV-1 tat interactive protein 1, homolog
, Tat-interactive protein-60
, lysine acetyltransferase 5
, HIV-1 Tat interacting protein, 60kDa
, HIV-1 Tat interactive protein 60 kD
, HIV-1 Tat interactive protein, 60 kD
, HIV-1 tat interactive protein, homolog
, Histone acetyltransferase HTATIP