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Our findings directly associate the AR/NCOA1 complex with PRKD1 (show PRKD1 ELISA Kits) regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in prostate cancer.
SRC-1 (show SRC ELISA Kits) can impact osteoblast function in an estrogen receptor (show ESR1 ELISA Kits)-independent manner.
The pregnane X receptor (show NR1I2 ELISA Kits) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (show SRC ELISA Kits) coactivator.
miR (show MLXIP ELISA Kits)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 (show TRAF4 ELISA Kits) and NCOA1 downstream of MEK (show MAP2K1 ELISA Kits)-C/EBP (show CEBPA ELISA Kits)-mediated leptin (show LEP ELISA Kits) and insulin (show INS ELISA Kits) signaling, and that insulin (show INS ELISA Kits) and/or leptin (show LEP ELISA Kits) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (show CALR ELISA Kits).
Results provide the first evidence that NCOA1 is a direct target of miR (show MLXIP ELISA Kits)-105-1 suggesting that NCOA1 and miR (show MLXIP ELISA Kits)-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC (show FAM126A ELISA Kits) patients.
Data suggest that steroid receptor (show ESR2 ELISA Kits) coactivators (NCOA1, NCOA2 (show NCOA2 ELISA Kits), NCOA3 (show NCOA3 ELISA Kits)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (show ESR2 ELISA Kits) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.
IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner
NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha (show HIF1A ELISA Kits) and AP-1 (show FOSB ELISA Kits)-mediated VEGFa (show VEGFA ELISA Kits) expression
miR (show MLXIP ELISA Kits)-137 has a role in targeting p160 (show MSH6 ELISA Kits) steroid receptor (show ESR2 ELISA Kits) coactivators SRC1 (show SRC ELISA Kits), SRC2 (show NCOA2 ELISA Kits), and SRC3 (show NCOA3 ELISA Kits) and inhibits cell proliferation
SRC-1 can impact osteoblast function in an estrogen receptor (show ESR1 ELISA Kits)-independent manner.
The results suggest that biochanin A activates RORgamma-dependent IL-17 (show IL17A ELISA Kits) transcription through the enhancement of STAT3 (show STAT3 ELISA Kits) phosphorylation and STAT3 (show STAT3 ELISA Kits)-mediated recruitment of NCOA1 to RORgamma.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.
local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics
SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (show SLC12A3 ELISA Kits)-like abnormalities in the hearts of newborn and adult mice.
While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.
fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A (show SFTPA1 ELISA Kits) and PAF (show KIAA0101 ELISA Kits) is crucial for this process
Consequently, SRC-1 null mice displayed low TAT (show TAT ELISA Kits) expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT (show TAT ELISA Kits) deficiency.
the effect of orchidectomy (ORX) on the expression of SRC-1
we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
, PAX3/NCOA1 fusion protein
, class E basic helix-loop-helix protein 74
, renal carcinoma antigen NY-REN-52
, steroid receptor coactivator-1
, nuclear receptor coactivator 1
, steroid receptor coactivator 1
, nuclear receptor coactivator protein 1