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RBM14 connects key paraspeckle subcomplexes via interactions mediated by its prion (show PRNP Proteins)-like domain.
This study identifies a cellular protein named RBM14 that is associated with XPO1 (CRM1 (show XPO1 Proteins)), a nuclear protein (show RDBP Proteins) that binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced HIV-1 viral RNAs
upon RBM14 depletion, a part of the ectopic centriolar protein complexes in turn assemble into structures more akin to centrioles, presumably by incorporating HsSAS-6 (show SASS6 Proteins), a cartwheel component, and cause multipolar spindle formation.
RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation.
CoAA is involved in the migration-enhancing action of PEA3 (show ETV4 Proteins) on MCF7 metastatic human cancer cells.
SYT (show SS18 Proteins) interacts with SYT-interacting protein/co-activator activator
The CoAA gene is amplified in human cancers
CoAA is a potential tumor suppressor in renal carcinoma and CoAM is a counterbalancing splice isoform.
The alternative splicing imbalance of CoAA and RBM4 (show RBM4 Proteins), because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation
CoAA binds Runx2 (show RUNX2 Proteins) and prevents Runx2 (show RUNX2 Proteins) binding to DNA; CoAA is expressed at high levels in human fetal osteoblasts and osteosarcoma cell lines
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene.
RNA binding motif protein 14
, RNA-binding protein 14
, RRM-containing coactivator activator/modulator
, SYT-interacting protein
, paraspeckle protein 2
, synaptotagmin-interacting protein
, transmembrane protein 137
, RNA-binding motif protein 14
, synaptotagmin interacting protein
, coactivator activator