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Browse our ube3a Proteins (ube3a)

Full name:
Ubiquitin Protein Ligase E3A Proteins (ube3a)
On www.antibodies-online.com are 8 Ubiquitin Protein Ligase E3A (ube3a) Proteins from 5 different suppliers available. Additionally we are shipping ube3a Antibodies (96) and ube3a Kits (14) and many more products for this protein. A total of 125 ube3a products are currently listed.
Synonyms:
4732496B02, 5830462N02Rik, A130086L21Rik, ANCR, As, CG6190, das, DDBDRAFT_0188760, DDBDRAFT_0302447, DDB_0188760, DDB_0302447, DKFZp459N106, Dmel\\CG6190, dube3a, E6-AP, EPVE6AP, Hpve6a, im:7140733, MGC69536, mKIAA4216, ube3a, UME3A, zgc:92173
list all proteins Gene Name GeneID UniProt
ube3a 7337 Q05086
Mouse ube3a ube3a 22215  
Rat ube3a ube3a 361585  

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ube3a Proteins (ube3a) by Origin

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More Proteins for ube3a Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Negative regulation of Tkv by Ube3a was conserved in mammalian cells. These results reveal a critical role for Ube3a in regulating NMJ synapse development by repressing BMP (show TGFb Proteins) signaling. This study sheds new light onto the neuronal functions of UBE3A and provides novel perspectives for understanding the pathogenesis of UBE3A-associated disorders.

  2. Data indicate that E3 ligase called ube3 (dube3a) is required for brain development as mutants have defective mushroom bodies.

  3. Rpn10 is targeted for degradation by Ube3a.

  4. In Drosophila melanogaster the human homologue ube3a regulates the actin cytoskeleton and neuronal homeostasis.

  5. MeCP2 (show MECP2 Proteins) and E6AP play a role in the transcriptional control of common target gene expression.

  6. Ube3a regulates serotonin and dopamine synthesis in the fly brain by increasing GTP cyclohydrolase I (show GCH1 Proteins) activity.

  7. dube3a null mutants appear normal externally, but display abnormal locomotive behavior and circadian rhythms, and defective long-term memory; overexpression in the nervous system caused locomotion defects, dependent on the ubiquitin ligase activity

  8. Overexpression of dUBE3A decreased dendritic branching.

Human Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. E6AP suppresses breast cancer metastasis by regulating actin cytoskeleton remodeling through the control of ECT2 (show ECT2 Proteins) and Rho GTPase (show RACGAP1 Proteins) activity.

  2. Dube3a is neither imprinted nor preferentially expressed from the maternal allele in fly neurons.

  3. The ubiquitylation of beta-catenin (show CTNNB1 Proteins) by E6AP was dependent on its E3 ubiquitin ligase (show MUL1 Proteins) activity, but it was proteasome-independent and did not require HPV16-E6.

  4. All patients with Angelman syndrome based on a deletion had epilepsy. Epilepsy was present in 3/4 children with UBE3A mutation. Laughter-induced postural muscle tone loss occurred only among deletion cases

  5. The results of Trans-well and cell scratch tests showed that when ANCR expression was decreased, the invasion and migration abilities of SW620 cells significantly declined (both P < 0.05). In conclusion, these results suggest that lncRNA-ANCR could influence the invasion and migration of CRC (show CALR Proteins) cells by specifically binding to EZH2 (show EZH2 Proteins).

  6. There were total 55 molecularly confirmed Angelman syndrome(AS) between January 1995 to September 2015 for review. 65.5% of them were caused by maternal microdeletion, 10.9% by paternal uniparental disomy, 3.6% by imprinting center defect and 14.5% by UBE3A gene mutation

  7. The observation of Dup15q syndrome in individuals with maternally but not paternally inherited duplications of chromosome 15q11-q13, suggest that UBE3A drives the Angelman syndrome phenotype in this disorder. (Review)

  8. our results indicate that CSN6 (show COPS6 Proteins) is a positive regulator of E6AP and is important for cervical cancer development.

  9. Stable over-expression of E6-AP increases the proliferation and invasion of prostate tumor cells.

  10. Impairments in both synaptic plasticity and fear conditioning memory in UBE3A-deficient mice are significantly ameliorated by blocking SK2. These results elucidate a mechanism by which UBE3A directly influences cognitive function.

Mouse (Murine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Based on our findings, we propose that imprinting of UBE3A does not function to reduce the dosage of UBE3A in neurons but rather to regulate some other, as yet unknown, aspect of gene expression or protein function

  2. the role of UBE3A is investigated in neurite contact guidance during neuronal development, is reported.

  3. Results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in Angelman syndrome mice, lending insight into ictogenic mechanisms in AS.

  4. Loss of Ube3a from tyrosine hydroxylase (show TH Proteins)-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.

  5. Results suggest that the phenotypes observed in Angelman syndrome mice may be modulated by factors independent of Ube3a genotype

  6. UBE3A dampens ERK (show EPHB2 Proteins) pathway signalling in HPV E6 transformed HeLa cells

  7. The normal window of development in Angelman syndrome patients is supported by an incompletely silenced paternal allele in developing neurons, resulting in a relative preservation of Ube3a expression during this crucial epoch of early development.

  8. Inactivation of Ube3a expression elevates BMAL1 (show ARNTL Proteins) levels in brain regions that control circadian behavior of AS-model mice, indicating an important role for Ube3a in modulating BMAL1 (show ARNTL Proteins) turnover.

  9. This study demonstrated that abnormal sleep patterns arise from a deficit in accumulation of sleep drive, uncovering the Ube3a gene as a novel genetic regulator of sleep homeostasis

  10. The deficiency of Ube3a in Huntington's disease (HD) mice brain also caused significant increase in global aggregates load, and these aggregates were less ubiquitinated when compared with age-matched HD mice.

Pig (Porcine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. In the skeletal muscle of neonate pigs, both NECD (show NDN Proteins) and SNRPN (show SNRPN Proteins) were maternally imprinted, while UBE3A was not imprinted.

ube3a Protein Profile

Protein Summary

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Alternative names and synonyms associated with ube3a

  • Ubiquitin protein ligase E3A (Ube3a)
  • ubiquitin protein ligase E3A (UBE3A)
  • ubiquitin-protein ligase E3A (ube3a)
  • ubiquitin protein ligase E3A (ube3a)
  • ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (ube3a)
  • ubiquitin protein ligase E3A (Eint_040430)
  • ubiquitin protein ligase E3A (Ube3a)
  • 4732496B02 protein
  • 5830462N02Rik protein
  • A130086L21Rik protein
  • ANCR protein
  • As protein
  • CG6190 protein
  • das protein
  • DDBDRAFT_0188760 protein
  • DDBDRAFT_0302447 protein
  • DDB_0188760 protein
  • DDB_0302447 protein
  • DKFZp459N106 protein
  • Dmel\\CG6190 protein
  • dube3a protein
  • E6-AP protein
  • EPVE6AP protein
  • Hpve6a protein
  • im:7140733 protein
  • MGC69536 protein
  • mKIAA4216 protein
  • ube3a protein
  • UME3A protein
  • zgc:92173 protein

Protein level used designations for ube3a

ubiquitin protein ligase E3A , CG6190-PA , Ube3a-PA , drosophila angelman syndrome , angelman syndrome , ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) , ubiquitin-protein ligase E3A , ubiquitin-protein ligase E3A-like , CTCL tumor antigen se37-2 , E6AP ubiquitin-protein ligase , human papilloma virus E6-associated protein , human papillomavirus E6-associated protein , oncogenic protein-associated protein E6-AP , renal carcinoma antigen NY-REN-54 , E6-AP ubiquitin protein ligase , ubiquitin conjugating enzyme E3A

GENE ID SPECIES
39266 Drosophila melanogaster
453269 Pan troglodytes
479010 Canis lupus familiaris
8627519 Dictyostelium discoideum AX4
100173699 Pongo abelii
100194730 Salmo salar
407881 Xenopus (Silurana) tropicalis
9699096 Encephalitozoon intestinalis ATCC 50506
100050725 Equus caballus
100385816 Callithrix jacchus
100438681 Pongo abelii
7337 Homo sapiens
22215 Mus musculus
792398 Danio rerio
533136 Bos taurus
361585 Rattus norvegicus
100522589 Sus scrofa
418686 Gallus gallus
100342825 Oryctolagus cuniculus
100730511 Cavia porcellus
380385 Xenopus laevis
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