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results highlight the importance of HTR1 in leukemogenesis and LSC (show ARHGEF1 Proteins) survival and identify this receptor family as a new target for therapy in AML (show RUNX1 Proteins) with prognostic value
HTR (show F2R Proteins) polymorphisms related to vulnerability to major depressive disorder (MDD) and MDD with suicidal attempts.
The results of this study give new evidence for the role of epigenetic and genetic factors which could modulate HTR1B expression in the pharmacological response to antidepressants.
5-HT1B receptor-dependent cellular Src (show SRC Proteins)-related kinase-Nox1 (show NOX1 Proteins)-pathways contribute to vascular remodeling in pulmonary arterial hypertension.
preliminary findings suggest a role of the HTR1B gene in susceptibility to development of bulimia nervosa subtypes. Furthermore, this gene might have an impact on the severity of anxiety in anorexia nervosa-spectrum patients.
Polymorphic variants of the HTR1B gene are associated with the susceptibility of secondary RP in vibration-exposed occupational populations of Chinese Han people.
large scale neural activation differences in the inferior and medial frontal and temporal/parietal regions of the response inhibition network between the different variants of both the HTR1B and 5HTT (show SLC6A4 Proteins) genes; activation in these regions was significantly associated with stop-task performance, but not with ADHD diagnosis or severity
Results from Parkinson's disease patients and MPTP (show PTPN2 Proteins)-lesioned monkeys argue in favor of a contribution of 5-HT1B receptors in the pathophysiology of levodopa-induced motor complications
The interaction between two major serotonergic structures involved in serotonin release, the SERT (show SLC6A4 Proteins) and 5-HT1B receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-HT1A (show HTR1A Proteins) receptors.
Serotonin 1B Receptor Gene (HTR1B) Methylation as a Risk Factor for Callous-Unemotional Traits in Antisocial Boys
The data show for the first time an important interactive relationship between SERT (show SLC6A4 Proteins) and the PDGFRbeta in the production of pulmonary artery smooth muscle cell proliferation triggered by PDGF (show PDGFA Proteins).
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
Combinational action of SERT (show SLC6A4 Proteins) and a 5-HT receptor in SMC (show DYM Proteins) growth and Rho A (show RHOA Proteins)/ROCK participation in 5-HT receptor 1B/1D-mediated mitogenesis of vascular SMCs through an effect on cytoplasmic to nuclear translocation of ERK1 (show MAPK3 Proteins)/ERK2 (show MAPK1 Proteins).
The relationship between polymorphisms at the HTR1B site and milk yield in Holstein cattle is reported.
vestibular ganglion cells were immunoreactive for 5-HT(1B) receptors in macaques and rats.
found high levels of serotonin receptor 1B mRNA in primary visual cortex (V1) and clear activity-dependent modulatory effects of 5-HT1B receptor agonists on responses of V1 neurons.
Consistent with previous studies that have optogenetically inhibited vHPC-mPFC projections, activating prefrontal 5-HT1B receptors suppressed theta-frequency mPFC activity (4-12 Hz), and reduced avoidance of anxiogenic regions in the elevated plus maze
we showed that gravity changes induced differential modulation of gene expression of BDNF (show BDNF Proteins) and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Mice lacking 5-HT1B autoreceptors displayed the expected increases in extracellular serotonin levels in the ventral hippocampus following administration of a selective serotonin reuptake inhibitor.
Data suggest that pharmacological stimulation of serotonin 5Ht1b receptor enhances up-regulation of plasma Glp1 (glucagon-like peptide 1 (show GCG Proteins)) induced by Dpp4 (dipeptidylpeptidase 4 (show DPP4 Proteins)) inhibition independently of feeding and also improves glucose tolerance.
5-HT1B Knockout and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in dopamine transporter Knockout mice.
The data of this study showed that while adolescent expression of 5-HT1BRs influences aggressive behavior, a distinct set of 5-HT1B receptors modulates impulsive behavior during adulthood.
The serotoninergic system plays an important role in the regulation of stress-induced depigmentation, which can be mediated by 5-HT1A (show HTR1A Proteins)/1B receptors.
5-HT(1B)R stimulation increased glutamatergic neurotransmission in the hippocampus in p11KO mice, but not in WT mice. Hippocampal p11 (show S100A10 Proteins) determines the directionality of 5-HT(1B)R action on emotional memory processing
Selective inhibition of 5-HT2A by sarpogrelate stimulated angiogenesis, restoring ischemic limb blood perfusion in a severe diabetic mouse model through stimulation of the eNOS (show NOS3 Proteins)/Akt (show AKT1 Proteins) pathway via the endothelial 5-HT1B receptor.
The neurotransmitter serotonin (5-hydroxytryptamine\; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992
, 5-hydroxytryptamine receptor 1B
, serotonin 1D beta receptor
, serotonin receptor 1B
, 5-hydroxytryptamine serotonin receptor 1B
, 5-hydroxytryptamine 1B receptor
, 5-HT1D beta receptor
, 5-HT1D beta
, 5-HT1D subtype beta
, 5-Hydroxytryptamine 1D receptor subtype beta
, 5-hydroxytryptamine (serotonin) receptor 1B
, 5-HT1B receptor
, 5-HT<1B> receptor
, 5-HT1B serotonin receptor
, 5-hydroxytryptamine (serotonin ) receptor 1B
, serotonin (5-hydroxytryptamine (5HT)) receptor type 1B
, drosophila serotonin receptor 1B
, serotonin receptor 2B
, 5-hydroxytryptamine receptor 1B-like
, Serotonin receptor 1B