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Browse our CISH Proteins (CISH)

Full name:
Cytokine Inducible SH2-Containing Protein Proteins (CISH)
On www.antibodies-online.com are 8 Cytokine Inducible SH2-Containing Protein (CISH) Proteins from 3 different suppliers available. Additionally we are shipping CISH Antibodies (23) and many more products for this protein. A total of 35 CISH products are currently listed.
Synonyms:
AI385595, BACTS2, Cis, CIS-1, CIS1, cish, cish.a, F17, F23, G18, ptk9l, SOCS, twf1l, wu:fk57g04, zgc:91817, zgc:154062
list all proteins Gene Name GeneID UniProt
CISH 1154 Q9NSE2
CISH 12700 Q62225
CISH 83681  

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CISH Proteins (CISH) by Origin

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More Proteins for CISH Interaction Partners

Zebrafish Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

  1. This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 (show STAT5B Proteins) in the control of embryonic hematopoiesis.

Rainbow Trout (Oncorhynchus mykiss) Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

  1. the type II SOCS genes (CISH, SOCS1 (show SOCS1 Proteins)-3) are particularly relevant to immune regulation in fish

Human Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

  1. This study showed that there was significantly increased levels of CIS mRNA in elderly and Alzheimer's disease brains.

  2. Data indicate that CIS protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with Elongin B (show TCEB2 Proteins)/C proteins, whereas CIS functional inhibition of PRLR (show PRLR Proteins) signaling is dependent on the Elongin B (show TCEB2 Proteins)/C interaction.

  3. SOCS single nucleotide polymorphism is associated with breast cancer.

  4. Study in Chinese Han population confirms that previously identified variants of CISH are associated with susceptibility to pulmonary tuberculosis.

  5. CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.

  6. Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population

  7. two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population

  8. CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis

  9. methylation of SOCS1 (show SOCS1 Proteins), SOCS2 (show SOCS2 Proteins), SOCS3 (show SOCS3 Proteins) and CISH is infrequent in Ph-ve MPN (show PRSS27 Proteins).

  10. data suggest FXR (show NR1H4 Proteins)-mediated upregulation of cytokine inducible SH2-containing protein (CISH) may play an important role in the homeostasis of cytokine signal networks and be beneficial to control cytokine-associated inflammatory diseases

Mouse (Murine) Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

  1. Data show that cytokine inducible SH2-containing protein Cish is induced upon T cell receptor stimulation and in the tumor microenvironment.

  2. Results show that CISH has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 (show SOCS2 Proteins) might compensate for the loss of Cish during pregnancy.

  3. CIS has a critical role in controlling the proallergic generation of helper T cells.

  4. CISH expression at the later stage of dendritic cell development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs.

  5. CIS and SOCS3 (show SOCS3 Proteins) play a role as negative feedback inhibitors of PRL (show PRL Proteins) action; Inhibition of CIS and SOCS3 (show SOCS3 Proteins) expression by glucocorticoids contributes to the positive effect of glucocorticoids on PRL (show PRL Proteins)-induced STAT5 (show STAT5A Proteins) activation.

  6. Induction of CIS in response to EPO (show EPO Proteins) stimulation depends on Stat5 (show STAT5A Proteins) but not MAP kinase (show MAPK1 Proteins) or PI 3 (show PI3 Proteins)-kinase. Overexpression negatively regulates EPO (show EPO Proteins)-mediated cell proliferation, Stat5 (show STAT5A Proteins) phosphorylation, & activation of a Stat (show STAT1 Proteins)-dependent luciferase reporter.

  7. CIS negatively regulates signaling at two levels, apoptosis and proliferation, and thereby sets a threshold for signal transduction

  8. IL-6 (show IL6 Proteins) inhibits hepatic GH signaling by upregulating Cis and Socs-3 (show SOCS3 Proteins), which may involve activation of STAT3 (show STAT3 Proteins).

  9. histone acetylation and chromatin remodeling events occurring during transcriptional activation of the endogenous murine Cis gene, a STAT5 (show STAT5A Proteins) target gene

  10. The desensitization of the JAK2 (show JAK2 Proteins)/STAT5b (show STAT5B Proteins) GH signaling pathway observed in pregnant mice would then be mainly related to increased CIS levels rather than to the other regulatory proteins examined.

CISH Protein Profile

Protein Summary

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CISH

  • cytokine inducible SH2-containing protein (CISH)
  • cytokine inducible SH2-containing protein (cish)
  • cytokine-inducible SH2-containing protein (cish)
  • Cytokine-inducible SH2-containing protein (cish)
  • cytokine inducible SH2-containing protein (Cish)
  • AI385595 protein
  • BACTS2 protein
  • Cis protein
  • CIS-1 protein
  • CIS1 protein
  • cish protein
  • cish.a protein
  • F17 protein
  • F23 protein
  • G18 protein
  • ptk9l protein
  • SOCS protein
  • twf1l protein
  • wu:fk57g04 protein
  • zgc:91817 protein
  • zgc:154062 protein

Protein level used designations for CISH

cytokine inducible SH2-containing protein , cytokine-inducible SH2-containing protein , cytokine inducible SH2 containing protein , cytokine inducible SH2-containing protein A , twinfilin, actin-binding protein, homolog 1, like , Cytokine-inducible SH2-containing protein , cytokine-inducible inhibitor of signaling type 1B , suppressor of cytokine signaling , CIS-1 , SOCS , cytokine-inducible SH2 protein , cytokine inducible SH2-containing protein 1 , CIS

GENE ID SPECIES
470819 Pan troglodytes
484757 Canis lupus familiaris
701456 Macaca mulatta
767678 Danio rerio
100135018 Xenopus (Silurana) tropicalis
100144307 Takifugu rubripes
100144373 Oryzias latipes
100190868 Gasterosteus aculeatus
100196184 Salmo salar
100329195 Oncorhynchus mykiss
1154 Homo sapiens
12700 Mus musculus
83681 Rattus norvegicus
616753 Bos taurus
395335 Gallus gallus
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