Browse our IFNB1 Proteins (IFNB1)

On are 67 Interferon, beta 1, Fibroblast (IFNB1) Proteins from 16 different suppliers available. Additionally we are shipping IFNB1 Antibodies (374) and IFNB1 Kits (102) and many more products for this protein. A total of 558 IFNB1 products are currently listed.
list all proteins Gene Name GeneID UniProt
IFNB1 15977 P01575
IFNB1 24481 P70499
IFNB1 3456 P01574

IFNB1 Proteins (IFNB1) by Origin

More Proteins for IFNB1 Interaction Partners

Rhesus Monkey Interferon, beta 1, Fibroblast (IFNB1) interaction partners

  1. either JC1 or DS1 C/EBP site is sufficient to mediate IFN beta-induced down-regulation of SIV long terminal repeat activity and virus replication in macrophages

  2. Hepatitis A virus protein 2B suppresses beta interferon (show IFNA Proteins) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.

Cow (Bovine) Interferon, beta 1, Fibroblast (IFNB1) interaction partners

  1. BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.

  2. The data confirm the involvement of EHMT2 (show EHMT2 Proteins) in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 (show EHMT2 Proteins) inhibition.

  3. The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).

  4. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 (show IRF3 Proteins) degradation.

  5. These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.

  6. recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha (show IFNA Proteins)/beta in bovine nasal fibroblasts and bronchoalveolar macrophages.

Mouse (Murine) Interferon, beta 1, Fibroblast (IFNB1) interaction partners

  1. study identifies a novel role for RIPK1 (show RIPK1 Proteins) and RIPK3 (show RIPK3 Proteins), a pair of homologous serine/threonine kinases previously implicated in the regulation of necroptosis and pathologic tissue injury, in directing IFN-beta production in macrophages

  2. results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.

  3. results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha (show IFNA Proteins)/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8 (show CD8A Proteins)(+) T cell response

  4. RIPK3 (show RIPK3 Proteins) regulates type I IFN both transcriptionally, by interacting with MAVS (show MAVS Proteins) and limiting RIPK1 (show RIPK1 Proteins) interaction with MAVS (show MAVS Proteins), and post-transcriptionally.

  5. neddylation contributes to HSV-1-induced early phase IFN-beta production.

  6. Rubicon (show KIAA0226 Proteins) specifically interacts with the interferon (show IFNA Proteins) regulatory factor (IRF (show TRIM63 Proteins)) association domain (IAD) of IRF3 (show IRF3 Proteins), and this interaction leads to inhibition of the dimerization of IRF3 (show IRF3 Proteins), which negatively regulates interferon (show IFNA Proteins)-mediated antiviral response.

  7. Translation arrest is further demonstrated to be key for anti-viral response by acting synergistically with MAVS (show MAVS Proteins) activation to amplify TBK1 (show TBK1 Proteins) signaling and IFN-beta mRNA transcription, while GADD34 (show PPP1R15A Proteins)-dependent protein synthesis recovery contributes to the heterogeneous expression of interferon (show IFNA Proteins) observed in dsRNA-activated cells.

  8. The authors report that Raf kinase inhibitory protein (RKIP (show PEBP1 Proteins)) is essential for TBK1 (show TBK1 Proteins) activation and type I interferon (show IFNA Proteins) production triggered by viral infection.

  9. this study shows that paracrine type I IFN can profoundly enhance innate recognition and TLR2-dependent transcriptional responses to Francisella tularensis infection upstream of its role in inflammasome regulation in primary murine peritoneal macrophages but not murine bone marrow-derived macrophages

  10. STAT2 (show STAT2 Proteins) recruits USP18 (show USP18 Proteins) to the type I IFN receptor subunit IFNAR2 (show IFNAR2 Proteins) via its constitutive membrane-distal STAT2 (show STAT2 Proteins)-binding site.

Human Interferon, beta 1, Fibroblast (IFNB1) interaction partners

  1. results demonstrate that Sphingosine 1-phosphate lyase (SPL (show SGPL1 Proteins)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (show IKBKE Proteins) and SPL (show SGPL1 Proteins), which provides a mechanistic understanding of the pro-IFN activity of SPL (show SGPL1 Proteins)

  2. results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.

  3. This study demonstrates a novel pathway for elevated IFNbeta signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNbeta and MAVS (show MAVS Proteins).

  4. G45R mutation of NS1 (show PTPN11 Proteins) slightly decreased NS1 (show PTPN11 Proteins) binding to dsRNA but did not interfere with its suppression of RIG-I (show DDX58 Proteins)-mediated type I IFN production.

  5. Upon influenza virus infection, DPF2 dysregulated IFN-beta induction and expression of cytokines/chemokines and antiviral proteins. This study provides evidence that influenza virus utilizes DPF2 to escape host innate immunity.

  6. Overexpression of PKV VP3 blocked IFN-beta-induced activation of the STAT1 (show STAT1 Proteins)/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) promoter in a dose-dependent manner.

  7. Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1 (show STAT1 Proteins)/2 induced by IFN-beta, but p-STAT1 (show STAT1 Proteins)/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 (show KPNA1 Proteins) and induces degradation of cellular KPNA1 (show KPNA1 Proteins) via caspase-3 (show CASP3 Proteins). [EV17 = Enterovirus 71]

  8. This study reveals that decreased induction of both PKR (show PKLR Proteins) and p300 (show EP300 Proteins) proteins contribute to impaired induction of IFN-beta in Chronic obstructive pulmonary disease primary bronchial epithelial cells upon influenza infection.

  9. Together, these results suggest that RSV infection of MSCs alters their immune regulatory function by upregulating IFN-b and IDO (show IDO1 Proteins), affecting immune cell proliferation, which may account for the lack of protective RSV immunity and for chronicity of RSV-associated lung diseases such as asthma and COPD (show ARCN1 Proteins).

  10. ArfGAP domain-containing protein 2 (ADAP2 (show ADAP2 Proteins)) is identified as a key novel scaffolding protein that integrates different modules of the RIG-I (show DDX58 Proteins) pathway, located at distinct subcellular locations, and mediates cellular antiviral type I interferon (show IFNA Proteins) production.

Pig (Porcine) Interferon, beta 1, Fibroblast (IFNB1) interaction partners

  1. Nuclear export of NSP1alpha of porcine reproductive and respiratory syndrome virus was necessary for its ability for IFN beta inhibition.

  2. Porcine deltacoronavirus nsp5 (show SPECC1 Proteins), the 3C-like protease, inhibits interferon-beta production through the cleavage of NEMO (show IKBKG Proteins).

  3. Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta expression mainly through attenuating IRF-3 (show IRF3 Proteins) phosphorylation.

  4. Porcine epidemic diarrhea virus nsp1 inhibited the IFN-beta and IRF3 (show IRF3 Proteins) promoter activities.

  5. poIFIT3 plays a significant role in the clearance of swine influenza virus in pigs and potentiates IFN-beta production.

  6. DDX41 (show DDX41 Proteins) is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells.

  7. VIral NS4 (show SOS1 Proteins) protein antagonizes beta interferon (show IFNA Proteins) expression by targeting the NF-kappaB (show NFKB1 Proteins) essential modulator.

  8. Swine IFN-beta promotes genetic mutation of porcine reproductive and respiratory syndrome virus.

  9. Expression of LSm14A (show LSM14A Proteins) in HEK293 or Marc (show CCL7 Proteins)-145 cells enhanced activities of IFN-beta and NF-kappaB (show NFKB1 Proteins) promoters, induced IFN-beta transcription, and potentiated IFN-beta promoter activation, indicating that LSm14A (show LSM14A Proteins) is a potential signal molecule (show WNT4 Proteins) in the IFN-beta pathway.

  10. Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (show IFNA Proteins)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (show IFNA Proteins) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.

IFNB1 Protein Profile

Protein Summary

suppresses the growth of rat glioma cells

Alternative names and synonyms associated with IFNB1

  • interferon, beta 1, fibroblast (IFNB1)
  • interferon, beta 1, fibroblast (LOC100342931)
  • interferon (alpha, beta and omega) receptor 2 (IFNAR2)
  • interferon beta 1, fibroblast (Ifnb1)
  • interferon, beta 1, fibroblast (IFNB)
  • IFB protein
  • IFF protein
  • IFN-beta protein
  • IFN-R protein
  • IFN-R-2 protein
  • IFNb protein
  • IFNBR protein

Protein level used designations for IFNB1

interferon beta , interferon beta 1 , interferon, beta 1, fibroblast , IFN-alpha-REC , IFN-alpha/beta receptor 2 , interferon alpha/beta receptor 2 , interferon, beta; receptor , interferon-alpha/beta receptor 2 , interferon-alpha/beta receptor beta chain , type I interferon receptor 2 , IFN-beta , interferon, beta 1 , fibroblast interferon , interferon type B , interferon-beta , interferon beta-1

711414 Macaca mulatta
100342931 Oryctolagus cuniculus
282258 Bos taurus
15977 Mus musculus
24481 Rattus norvegicus
3456 Homo sapiens
554219 Gallus gallus
445459 Sus scrofa
493849 Felis catus
100052545 Equus caballus
481558 Canis lupus familiaris
281845 Bos taurus
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