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Browse our anti-IL12B (IL12B) Antibodies

Full name:
anti-Interleukin 12b Antibodies (IL12B)
On www.antibodies-online.com are 250 Interleukin 12b (IL12B) Antibodies from 32 different suppliers available. Additionally we are shipping IL12B Kits (98) and IL12B Proteins (83) and many more products for this protein. A total of 459 IL12B products are currently listed.
Synonyms:
CLMF, CLMF2, IL-12, IL-12.p40, Il-12b, IL-12p40, Il12, IL12B, IL12p40, NKSF, NKSF2, p40
list all antibodies Gene Name GeneID UniProt
IL12B 16160 P43432
IL12B 64546  
IL12B 3593 P29460

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Most Popular Reactivities for anti-IL12B (IL12B) Antibodies

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anti-Mouse (Murine) IL12B Antibodies:

anti-Rat (Rattus) IL12B Antibodies:

anti-Human IL12B Antibodies:

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Top referenced anti-IL12B Antibodies

  1. Human Polyclonal IL12B Primary Antibody for EIA, FACS - ABIN952920 : Sobti, Salih, Nega, Seyed, Rupinder, Vijesh, Ajay: Insights into the role of IL-12B and IFN-gamma cytokine gene polymorphisms in HIV-1/AIDS infection. in Folia biologica 2010 (PubMed)
    Show all 2 references for ABIN952920

  2. Human Polyclonal IL12B Primary Antibody for ELISA, IHC - ABIN4325518 : Sheth, De, Nolan, Friel, Duffy, Ricciardi, Miller-Graziano, Bankey: Heat shock protein 27 inhibits apoptosis in human neutrophils. in The Journal of surgical research 2001 (PubMed)

  3. Human Polyclonal IL12B Primary Antibody for IHC (p), WB - ABIN2176964 : Li, Dan, Nie, Hu, Gesang, Bianba, Ze, Ciren: CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts. in Molecular medicine reports 2015 (PubMed)

  4. Human Monoclonal IL12B Primary Antibody for FACS - ABIN1107790 : Ito, Amakawa, Kaisho, Hemmi, Tajima, Uehira, Ozaki, Tomizawa, Akira, Fukuhara: Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. in The Journal of experimental medicine 2002 (PubMed)

  5. Mouse (Murine) Polyclonal IL12B Primary Antibody for ELISA, WB - ABIN408670 : Stäger, Maroof, Zubairi, Sanos, Kopf, Kaye: Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. in European journal of immunology 2006 (PubMed)

  6. Mouse (Murine) Polyclonal IL12B Primary Antibody for WB - ABIN374932 : Gui, Xiong, Yang, Li, Huang: Effects of acupuncture on LIF and IL-12 in rats of implantation failure. in American journal of reproductive immunology (New York, N.Y. : 1989) 2012 (PubMed)

More Antibodies against IL12B Interaction Partners

Mouse (Murine) Interleukin 12b (IL12B) interaction partners

  1. Irradiation-induced IL-6 (show IL6 Antibodies) can decrease IL-12 (show IL12A Antibodies) production through the inhibition of C-Rel (show NFkBP65 Antibodies) phosphorylation by the IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway.

  2. The IL-12 (show IL12A Antibodies) response by dendritic cells against S. aureus is highly growth phase dependent.

  3. the PI3K pathway mediated IL-12 (show IL12A Antibodies) inhibition but did not interfere with the inhibition of IL-23 (show IL23A Antibodies) or stimulation of IL-10 (show IL10 Antibodies).

  4. Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.

  5. this study demonstrates viral RNA analog-induced transcription synergy of Il6 (show IL6 Antibodies) and Il12b via IFN regulatory factor (IRF)1 (show IRF1 Antibodies) (TLR3 (show TLR3 Antibodies)-TIR domain-containing adaptor inducing IFN-beta (show TICAM1 Antibodies) [TRIF (show RNF138 Antibodies)] responsive), C/EBPbeta (show CEBPB Antibodies) (TLR7 (show TLR7 Antibodies)-MyD88 (show MYD88 Antibodies) responsive), and JunB (show JUNB Antibodies) (all responsive).

  6. These findings reveal a critical role for IL-12 (show IL12A Antibodies) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.

  7. our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.

  8. The systemic IL-10 (show IL10 Antibodies)/IL-12 (show IL12A Antibodies) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (show IL10 Antibodies) and polarization of neutrophils into an anti-inflammatory IL-12 (show IL12A Antibodies)-negative phenotype.

  9. the assembled p40 (show LANCL1 Antibodies)-CD5L (show CD5L Antibodies) heterodimer does not recapitulate the biological activity of IL-12 (show IL12A Antibodies).

  10. The immune-enhancing effect of the Cronobacter sakazakii ES2 (show DGCR14 Antibodies) phage results in the activation of nuclear factor-kappaB and dendritic cell maturation via the activation of IL-12p40 in the mouse bone marrow.

Human Interleukin 12b (IL12B) interaction partners

  1. Suggest Il12B SNPs as genetic marker of disease severity in Takayasu arteritis severity.

  2. The results of this study suggested that rs6887695 SNP in IL12B gene increase susceptibility to relapsing-remitting multiple sclerosis.

  3. The results of this case-control study suggest that IL-12A (show IL12A Antibodies), IL-12B, IL12RB1 (show IL12RB1 Antibodies), IL12RB2 (show IL12RB2 Antibodies) and IL23R (show IL23R Antibodies) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations

  4. these meta-analyses demonstrated that IL-12B rs3212227 and rs6887695 polymorphisms do not confer susceptibility to rheumatoid arthritis [data synthesis]

  5. The present meta-analysis suggests that the IL12B +1188A/C (rs3212227) polymorphism might be associated with genetic susceptibility to autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis and Behcet disease, but not Graves disease and ankylosing spondylitis.

  6. suberoylanilide hydroxamic acid significantly inhibited IL-12p40 and IL-23p19 mRNA synthesis and did not change IL-12p35 mRNA transcription.

  7. The levels of IL-8 (show IL8 Antibodies), IL-12 (show IL12A Antibodies), and adrenomedullin (show ADM Antibodies) may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF (show SCN5A Antibodies).

  8. this study shows that IL-12B gene polymorphism does not contribute to the risk of hepatocellular carcinoma on top of chronic hepatitis C virus infection in Egyptian patients

  9. Data showed that Actinobacillus (Aggregatibacter) actinomycetemicomitans GroEL protein (show GroEL Antibodies) has an antigenic effect on human primary monocytes. Aa GroEL protein (show GroEL Antibodies) responsive CD14 (show NDUFA2 Antibodies) monocytes stimulates the expression of IL12 (show IL12A Antibodies), IL10 (show IL10 Antibodies), IFNG (show IFNG Antibodies) and TNFalpha (show TNF Antibodies) cytokines with different kinetics and expression profile.

  10. this study has demonstrated (i) a significant association of -1082GG IL-10 (show IL10 Antibodies) genotype with susceptibility to autoimmune thyroid disease and (ii) the concomitant presence of IL-12B +1188CC and IL-10 (show IL10 Antibodies)-1082 GG genotype contributes to the development and progression of Hashimoto's thyroiditis

Cow (Bovine) Interleukin 12b (IL12B) interaction partners

  1. The results showed that the expression of TNF-alpha (show TNF Antibodies), iNOS (show NOS2 Antibodies), and IL-6 (show IL6 Antibodies) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Antibodies) was unaffected.[IL-6 (show IL6 Antibodies), IL-12 (show IL12A Antibodies)]

  2. study investigated hypothesis that CD40 (show CD40 Antibodies) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (show NOS2 Antibodies) and IL-12p40 genes downstream of p38 (show MAPK14 Antibodies)

Rhesus Monkey Interleukin 12b (IL12B) interaction partners

  1. In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (show TLR7 Antibodies)/8 and TLR-9 (show TLR9 Antibodies) stimulation, which could potentially affect their response to vaccination and viral infection.

Pig (Porcine) Interleukin 12b (IL12B) interaction partners

  1. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Antibodies), IL-6 (show IL6 Antibodies), IL-12p40, IL-1beta (show IL1B Antibodies), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Antibodies) and bcl2L1 (show BCL2L1 Antibodies).

IL12B Antigen Profile

Antigen Summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative names and synonyms associated with IL12B

  • interleukin 12 p40 subunit (IL-12) antibody
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A) antibody
  • interleukin 12b (Il12b) antibody
  • interleukin 12B (Il12b) antibody
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B) antibody
  • CLMF antibody
  • CLMF2 antibody
  • IL-12 antibody
  • IL-12.p40 antibody
  • Il-12b antibody
  • IL-12p40 antibody
  • Il12 antibody
  • IL12B antibody
  • IL12p40 antibody
  • NKSF antibody
  • NKSF2 antibody
  • p40 antibody

Protein level used designations for anti-Interleukin 12b (IL12B) Antibodies

CLMF p40 , Cytotoxic lymphocyte maturation factor 40 kDa subunit , IL-12 subunit p40 , Interleukin-12 subunit beta , CLMF p35 , IL-12 subunit p35 , IL-12A , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12B , interleukin-12 p35 subunit , interleukin-12 subunit alpha , IL-12 p40 , IL-23 subunit p40 , cytotoxic lymphocyte maturation factor 40 kDa subunit , interleukin-12 subunit beta , interleukin-12 p40 , IL-12B , interleukin-12 p40 subunit , IL12, subunit p40 , NK cell stimulatory factor chain 2 , interleukin 12, p40 , interleukin-12 beta chain , natural killer cell stimulatory factor, 40 kD subunit , interleukin 12 40kDa subunit , interleukin 12 p40 subunit , interleukin-12 p40 chain , IL-12 p40 subunit , interleukin-12p40

GENE ID SPECIES
100860845 Capra hircus
403977 Canis lupus familiaris
16160 Mus musculus
64546 Rattus norvegicus
100135554 Cavia porcellus
3593 Homo sapiens
281857 Bos taurus
443472 Ovis aries
403976 Canis lupus familiaris
100034222 Equus caballus
768273 Felis catus
694747 Macaca mulatta
404671 Gallus gallus
397076 Sus scrofa
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