Browse our IL12B Proteins (IL12B)

Full name:
Interleukin 12b Proteins (IL12B)
On are 83 Interleukin 12b (IL12B) Proteins from 19 different suppliers available. Additionally we are shipping IL12B Antibodies (244) and IL12B Kits (103) and many more products for this protein. A total of 456 IL12B products are currently listed.
CLMF, CLMF2, IL-12, IL-12.p40, Il-12b, IL-12p40, Il12, IL12B, IL12p40, NKSF, NKSF2, p40
list all proteins Gene Name GeneID UniProt
IL12B 16160 P43432
IL12B 64546  
IL12B 3593 P29460

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IL12B Proteins (IL12B) by Origin

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Top referenced IL12B Proteins

  1. Rat (Rattus) IL12B Protein expressed in Human Cells - ABIN2009536 : Sieburth, Jabs, Warrington, Li, Lasota, LaForgia, Kelleher, Huebner, Wasmuth, Wolf: Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. in Genomics 1992 (PubMed)
    Show all 5 references for 2009536

  2. Mouse (Murine) IL12B Protein expressed in Human Cells - ABIN2008511 : Gearing, Cosman: Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. in Cell 1991 (PubMed)
    Show all 5 references for 2008511

  3. Human IL12B Protein expressed in Human Cells - ABIN2001973 : Thierfelder, van Deursen, Yamamoto, Tripp, Sarawar, Carson, Sangster, Vignali, Doherty, Grosveld, Ihle: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. in Nature 1996 (PubMed)
    Show all 5 references for 2001973

  4. Mouse (Murine) IL12B Protein expressed in Human Cells - ABIN2008513 : Ling, Gately, Gubler, Stern, Lin, Hollfelder, Su, Pan, Hakimi: Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 4 references for 2008513

  5. Marmoset IL12B Protein expressed in Human Cells - ABIN2010101 : Kato, Shimozato, Hoshi, Wakimoto, Hamada, Yagita, Okumura: Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 4 references for 2010101

  6. Rat (Rattus) IL12B Protein expressed in Human Cells - ABIN2009538 : Kim, Loveland, Sitz, Ratto Kim, Mclinden, Tencer, Davis, Burke, Boswell, Redfield, Birx: Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1. in Clinical and experimental immunology 1997 (PubMed)
    Show all 4 references for 2009538

  7. Human IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1047232 : Wolf, Temple, Kobayashi, Young, Dicig, Lowe, Dzialo, Fitz, Ferenz, Hewick: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. in Journal of immunology (Baltimore, Md. : 1950) 1991 (PubMed)
    Show all 3 references for 1047232

  8. Human IL12B Protein expressed in Hi-5 - ABIN1098598 : Oppmann, Lesley, Blom, Timans, Xu, Hunte, Vega, Yu, Wang, Singh, Zonin, Vaisberg, Churakova, Liu, Gorman, Wagner, Zurawski, Liu, Abrams, Moore, Rennick, de Waal-Malefyt, Hannum, Bazan, Kastelein: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. in Immunity 2001 (PubMed)
    Show all 2 references for 1098598

More Proteins for IL12B Interaction Partners

Mouse (Murine) Interleukin 12b (IL12B) interaction partners

  1. this study shows that a systemic IL-12 (show IL12A Proteins) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis

  2. this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (show IL12A Proteins) production is inhibited by TLR stimulation from the plasma membrane

  3. Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 (show IL12A Proteins) production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.

  4. The IL-12 (show IL12A Proteins) response by dendritic cells against S. aureus is highly growth phase dependent.

  5. the PI3K pathway mediated IL-12 (show IL12A Proteins) inhibition but did not interfere with the inhibition of IL-23 (show IL23A Proteins) or stimulation of IL-10 (show IL10 Proteins).

  6. Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.

  7. this study demonstrates viral RNA analog-induced transcription synergy of Il6 (show IL6 Proteins) and Il12b via IFN regulatory factor (IRF)1 (show IRF1 Proteins) (TLR3 (show TLR3 Proteins)-TIR domain-containing adaptor inducing IFN-beta (show TICAM1 Proteins) [TRIF (show RNF138 Proteins)] responsive), C/EBPbeta (show CEBPB Proteins) (TLR7 (show TLR7 Proteins)-MyD88 (show MYD88 Proteins) responsive), and JunB (show JUNB Proteins) (all responsive).

  8. These findings reveal a critical role for IL-12 (show IL12A Proteins) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.

  9. our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.

  10. The systemic IL-10 (show IL10 Proteins)/IL-12 (show IL12A Proteins) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (show IL10 Proteins) and polarization of neutrophils into an anti-inflammatory IL-12 (show IL12A Proteins)-negative phenotype.

Human Interleukin 12b (IL12B) interaction partners

  1. Pre-incubation with IL-12 (show IL12A Proteins) was able to restore IFN-gamma (show IFNG Proteins) production and the cytotoxicity capacities of NK cells. This cytokine may therefore be considered as a potential treatment candidate in traumatic brain injury patients with immune suppression.

  2. NOD2 rs3135500 and IL12B rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.

  3. assembly-induced folding is key in IL-12 (show IL12A Proteins) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (show IL12A Proteins) cytokine

  4. IL-12B gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients

  5. this study shows that that IL-12 (show IL12A Proteins) and IL-4 (show IL4 Proteins) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation

  6. The data suggested the association of IL12B with the psoriasis, however no evidence was observed for the epistatic effect of IL12B with HLA-Cw6 among the psoriasis patients in India.

  7. In summary, this meta-analysis finds that IL6 (show IL6 Proteins) rs1800795 and IL18 (show IL18 Proteins) rs1946518 polymorphisms decrease the risk of BD. However, IL12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary.

  8. Suggest Il12B SNPs as genetic marker of disease severity in Takayasu arteritis severity.

  9. The results of this study suggested that rs6887695 SNP in IL12B gene increase susceptibility to relapsing-remitting multiple sclerosis.

  10. The results of this case-control study suggest that IL-12A (show IL12A Proteins), IL-12B, IL12RB1 (show IL12RB1 Proteins), IL12RB2 (show IL12RB2 Proteins) and IL23R (show IL23R Proteins) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations

Cow (Bovine) Interleukin 12b (IL12B) interaction partners

  1. The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 (show IL6 Proteins) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6 (show IL6 Proteins), IL-12 (show IL12A Proteins)]

  2. study investigated hypothesis that CD40 (show CD40 Proteins) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (show NOS2 Proteins) and IL-12p40 genes downstream of p38 (show MAPK14 Proteins)

Rhesus Monkey Interleukin 12b (IL12B) interaction partners

  1. In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (show TLR7 Proteins)/8 and TLR-9 (show TLR9 Proteins) stimulation, which could potentially affect their response to vaccination and viral infection.

Pig (Porcine) Interleukin 12b (IL12B) interaction partners

  1. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1 (show BCL2L1 Proteins).

IL12B Protein Profile

Protein Summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative names and synonyms associated with IL12B

  • interleukin 12 p40 subunit (IL-12)
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)
  • interleukin 12b (Il12b)
  • interleukin 12B (Il12b)
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B)
  • CLMF protein
  • CLMF2 protein
  • IL-12 protein
  • IL-12.p40 protein
  • Il-12b protein
  • IL-12p40 protein
  • Il12 protein
  • IL12B protein
  • IL12p40 protein
  • NKSF protein
  • NKSF2 protein
  • p40 protein

Protein level used designations for Interleukin 12b Proteins (IL12B)

CLMF p40 , Cytotoxic lymphocyte maturation factor 40 kDa subunit , IL-12 subunit p40 , Interleukin-12 subunit beta , CLMF p35 , IL-12 subunit p35 , IL-12A , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12B , interleukin-12 p35 subunit , interleukin-12 subunit alpha , IL-12 p40 , IL-23 subunit p40 , cytotoxic lymphocyte maturation factor 40 kDa subunit , interleukin-12 subunit beta , interleukin-12 p40 , IL-12B , interleukin-12 p40 subunit , IL12, subunit p40 , NK cell stimulatory factor chain 2 , interleukin 12, p40 , interleukin-12 beta chain , natural killer cell stimulatory factor, 40 kD subunit , interleukin 12 40kDa subunit , interleukin 12 p40 subunit , interleukin-12 p40 chain , IL-12 p40 subunit , interleukin-12p40

100860845 Capra hircus
403977 Canis lupus familiaris
16160 Mus musculus
64546 Rattus norvegicus
100135554 Cavia porcellus
3593 Homo sapiens
281857 Bos taurus
443472 Ovis aries
403976 Canis lupus familiaris
100034222 Equus caballus
768273 Felis catus
694747 Macaca mulatta
404671 Gallus gallus
397076 Sus scrofa
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