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Human IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305061
DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993
Show all 5 Pubmed References
Mouse (Murine) IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305060
DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. in The Journal of experimental medicine 1992
Show all 4 Pubmed References
Human IL12B Protein expressed in Human Cells - ABIN2648866
Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. in Nature immunology 2015
this study shows that a systemic IL-12 (show IL12A Proteins) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (show IL12A Proteins) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 (show IL12A Proteins) production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.
The IL-12 (show IL12A Proteins) response by dendritic cells against S. aureus is highly growth phase dependent.
the PI3K pathway mediated IL-12 (show IL12A Proteins) inhibition but did not interfere with the inhibition of IL-23 (show IL23A Proteins) or stimulation of IL-10 (show IL10 Proteins).
Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.
this study demonstrates viral RNA analog-induced transcription synergy of Il6 (show IL6 Proteins) and Il12b via IFN regulatory factor (IRF)1 (show IRF1 Proteins) (TLR3 (show TLR3 Proteins)-TIR domain-containing adaptor inducing IFN-beta (show TICAM1 Proteins) [TRIF (show RNF138 Proteins)] responsive), C/EBPbeta (show CEBPB Proteins) (TLR7 (show TLR7 Proteins)-MyD88 (show MYD88 Proteins) responsive), and JunB (show JUNB Proteins) (all responsive).
These findings reveal a critical role for IL-12 (show IL12A Proteins) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.
our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.
The systemic IL-10 (show IL10 Proteins)/IL-12 (show IL12A Proteins) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (show IL10 Proteins) and polarization of neutrophils into an anti-inflammatory IL-12 (show IL12A Proteins)-negative phenotype.
Simultaneous elevated circulating levels of IL-18 (show IL18 Proteins) and IL-12 (show IL12A Proteins) increased the event rate after 2 years in Coronary Artery Disease patients, independent of hyperglycemia
Single-nucleotide-polymorphisms of IL12B may be considered a high-risk factor for Takayasu arteritis in Chinese Han population
IL-12B -1188 C allele may be a protective factor against asthma in East Asians
The low expression of HDAC3 (show HDAC3 Proteins) and overexpession of inflammatory cytokines (IL-18 (show IL18 Proteins), IL-12 (show IL12A Proteins) and TNF-alpha (show TNF Proteins)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
Polymorphisms of IFNG (show IFNG Proteins), IL12B and IL12RB1 (show IL12RB1 Proteins) genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
Identification of PARP-1 (show PARP1 Proteins) as a unique regulator of Il12b transcription in response to inflammatory insults in an allele-differentiating manner
Pre-incubation with IL-12 (show IL12A Proteins) was able to restore IFN-gamma (show IFNG Proteins) production and the cytotoxicity capacities of NK cells. This cytokine may therefore be considered as a potential treatment candidate in traumatic brain injury patients with immune suppression.
NOD2 rs3135500 and IL12B rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.
assembly-induced folding is key in IL-12 (show IL12A Proteins) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (show IL12A Proteins) cytokine
IL-12B gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients
The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 (show IL6 Proteins) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6 (show IL6 Proteins), IL-12 (show IL12A Proteins)]
study investigated hypothesis that CD40 (show CD40 Proteins) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (show NOS2 Proteins) and IL-12p40 genes downstream of p38 (show MAPK14 Proteins)
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (show TLR7 Proteins)/8 and TLR-9 (show TLR9 Proteins) stimulation, which could potentially affect their response to vaccination and viral infection.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1 (show BCL2L1 Proteins).
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, IL-12 subunit p40
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin 12, p40
, interleukin-12 beta chain
, interleukin-12 subunit beta
, natural killer cell stimulatory factor, 40 kD subunit
, CLMF p35
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12
, interleukin-12 subunit alpha
, IL-12 p40
, IL-23 subunit p40
, interleukin-12 p40
, interleukin-12 p40 subunit
, interleukin 12B
, interleukin-12 p35 subunit
, IL-12 p40 subunit
, interleukin 12 p40.b
, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, interleukin 12 40kDa subunit
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, Interleukin-12 subunit beta