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Rat (Rattus) Leptin Receptor ELISA Kit for Sandwich ELISA - ABIN416360
Feng, Shao, Weijdegård, Wang, Johansson, Sun, Wang, Egecioglu, Billig, Stener-Victorin: Effects of androgen and leptin on behavioral and cellular responses in female rats. in Hormones and behavior 2011
Human Leptin Receptor ELISA Kit for Sandwich ELISA - ABIN365403
Catli, Anik, Tuhan, Kume, Bober, Abaci: The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children. in Peptides 2014
systematic review and meta-analysis indicated that the LEPR gene variants (rs6700896, 109G allele, and 109GG genotype) were significantly associated with increased risk of cardiovascular disease (CVD); however, the present study is limited in its small number of included studies, considerable heterogeneity and observational study design
Leptin receptor Gln223Arg polymorphism does not appear to be related to male fertility.
In tissue samples, hypoxia-inducible factor 1-alpha (show HIF1A ELISA Kits) messenger RNA and protein expression of leptin (show LEP ELISA Kits) and leptin receptor were high in oral squamous cell carcinoma cases. Serum leptin (show LEP ELISA Kits) levels were increased in first clinical stages of the disease.
LEPR polymorphisms are associated with type 2 diabetes risk. [Meta-Analysis]
over-expression of LEPR, rather than that of LEP (show LEP ELISA Kits) has a fundamental role in breast carcinogenesis in particular, and probably for LEP (show LEP ELISA Kits)-LEPR associated tumors in general
Data suggest that hypothalamic leptin/leptin (show LEP ELISA Kits) receptor signaling plays a critical role in neurodevelopment, sympathetic activation, and prevention/development of hypertension. [REVIEW]
leptin (show LEP ELISA Kits)-LepRb plays an important role in the pathogenesis and depression in gastric cancer
In 2 unrelated girls with severe obesity, three novel LEPR mutations were detected. Longitudinal growth data show normal childhood growth, and in the older girl, a normal adult height despite hypogonadotropic hypogonadism and the lack of an obvious pubertal growth spurt (show BPIFA1 ELISA Kits).
genetic variability in the LEPR gene is associated with idiopathic recurrent spontaneous abortion; more frequent LEPR genotype in patients - rs7516341 (nominal P=0.034, odds ratio [OR] 0.61, 95% confidence interval [CI] 0.38-0.97) and rs1137101 (nominal P=0.048, OR 1.66, 95% CI 1.00-2.80)
our findings suggest that leptin (show LEP ELISA Kits) promoted the proliferation, migration and invasion of gallbladder cancer (GBC) cells by increasing OB-Rb expression through the SOCS3 (show SOCS3 ELISA Kits)/JAK2 (show JAK2 ELISA Kits)/p-STAT3 (show STAT3 ELISA Kits) signal pathway. Targeting the leptin (show LEP ELISA Kits)/OB-Rb axis could be an attractive therapeutic strategy for treatment of GBC.
Neurotensin (show NTS ELISA Kits)-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.
Suggest that intact endothelial leptin (show LEP ELISA Kits) signaling limits neointima formation and that obesity represents a state of endothelial leptin (show LEP ELISA Kits) resistance.
Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA (show PDGFRA ELISA Kits) signalling could be an effective way to treat bone marrow fibrosis.
Leptin (show LEP ELISA Kits) expression is regulated by DNA methylation (show HELLS ELISA Kits) in adipocytes.
Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1 (show PRDM1 ELISA Kits)).
LepRb preoptic area neurons are stimulatory glutamatergic neurons, contrary to prevalent models
Leptin (show LEP ELISA Kits) receptors on agouti-related peptide neurons modulate the onset of puberty and adult fertility.
Leptin (show LEP ELISA Kits)/LepR signaling regulates adipogenesis and osteogenesis by mesenchymal stromal cells in the bone marrow in response to diet and adiposity.
These data show that leptin (show LEP ELISA Kits) directly impairs vascular relaxation via a vascular skeletal muscle-LepR-mediated mechanism, suggesting a potential pathogenic role for leptin (show LEP ELISA Kits) to increase cardiovascular risk during obesity.
These mice showed an increase in FSH (show BRD2 ELISA Kits) levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin (show LEP ELISA Kits)-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.
LEPR showed a lower variability than LEP (show LEP ELISA Kits) in the different analysed populations, especially in the Iberian breed that showed no variability
Superactive human leptin (show LEP ELISA Kits) antagonist reverses leptin (show LEP ELISA Kits)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (show LEP ELISA Kits) receptors.
The presence of leptin (show LEP ELISA Kits) and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP (show LEP ELISA Kits)/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP (show LEP ELISA Kits)/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (show LEP ELISA Kits)
Leptin (show LEP ELISA Kits) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (show LEP ELISA Kits) mRNA expression as well as E and P on leptin (show LEP ELISA Kits) secretion by those cells obtained in early pregnancy.
These data suggest that leptin (show LEP ELISA Kits) might have a direct effect on porcine follicles and plays an important role in the follicular development.
Locally produced leptin (show LEP ELISA Kits) plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.
results suggest the T alleles of both LEP (show LEP ELISA Kits) g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake
Here, the association between DGAT1 (show DGAT1 ELISA Kits) K232A, SCD1 (show SCD ELISA Kits) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (show DGAT1 ELISA Kits), SCD1 (show SCD ELISA Kits), and LEPR polymorphisms were GC/GC (show GC ELISA Kits), C, and C, respectively.
I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression
The results suggest that a mutation of SCD1 (show SCD ELISA Kits), but not LEPR or ABCG2 (show ABCG2 ELISA Kits), might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
SNP LEP (show LEP ELISA Kits) significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
The use of leptin (show LEP ELISA Kits), leptin receptor, and DGAT1 (show DGAT1 ELISA Kits) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
The leptin (show LEP ELISA Kits) and receptor gene markers would be useful for marker-assisted selection.
The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.
The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.
the possible involvement of locally produced leptin (show LEP ELISA Kits)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.
findings indicate that acetate and butyrate enhance leptin (show LEP ELISA Kits) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries
A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).
These results indicate that horse major salivary glands, like those of humans, are likely targets of leptin (show LEP ELISA Kits) actions, suggesting a functional role of leptin (show LEP ELISA Kits) on these glands.
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
, leptin receptor gene-related protein
, Leptin receptor (fatty)
, cytokine receptor
, leptin receptor long insert isoform
, OB-R gene-related protein