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The predominant role of leukemia inhibitory factor receptor in skeletal muscle regeneration appears to be in regulating the inflammatory response rather than directly effecting myogenic cells.
both LIFR and gp130 (show LRPPRC Proteins) protein expression were increased in the sciatic nerve and gastrocnemius muscle of diabetic mice.
Dat (show LIF Proteins)a confirmed that LIF and the LIFR were up-regulated in intra-implantation sites compared to inter-implantation sites on Day 5 of gestation.
Data demonstrate that T cells retain responsiveness to a LIF (show LIF Proteins)/Nanog (show NANOG Proteins) axis and that this axis is linked to MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.
Neuropoietin (show CTF2 Proteins) induced activation of STAT3 (show STAT3 Proteins) tyrosine phosphorylation in adipocytes is independent of LIFR phosphorylation and degradation.
Review. The structure and function of the LIF-R gene and protein and the role of its cytoplasmic domain in myeloid leukemia (show BCL11A Proteins) cells are reviewed.
LIFR plays a role in modulating fetal response to high maternal glucocorticoids in late gestation, likely mediated through the glucocorticoid receptor (show NR3C1 Proteins), with implications for adult homeostasis as a direct tie between immune, neural & hormone function.
LIFR signaling can exert negative regulatory effects on neurite extension and branching of sympathetic neurons
Although not necessary for neural stem cell self-renewal, LIFR activation enhances both the clonogenicity and expression of glial fibrillary acid protein (GFAP (show GFAP Proteins)) by these multipotential cells.
Lifr -/- mice demonstrate elevated pituitary glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA and protein levels, indicating the importance of LIF (show LIF Proteins) signaling for hypothalamic-pituitary adrenal axis development.
The C65S mutant LIFR showed altered glycosylation and an elevated expression level that might be attributed to a slow turnover of the mutant form.
High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma.
Stuve-Wiedemann syndrome patients with (p.Arg692X) LIFR mutation may develop central adrenal insufficiency due to impaired LIF/LIFR signalling. LIF/LIFR system plays a role in human HPA (show HPSE Proteins) axis regulation.
these findings conclude that LIFR functions as a novel metastasis suppressor in Hepatocellular carcinoma and may serve as a prognostic biomarker for Hepatocellular carcinoma patients.
LIFR may play a functional role in hepatocarcinogenesis
Expression of the LIF receptor was strongly increased on immune cells of multiple sclerosis patients.
Studied the association of tubal pregnancy with leukemia inhibitory factor (LIF (show LIF Proteins)) and leukemia inhibitory factor receptor (LIFR) expression in oviduct tissues.
The LIFRalpha-CT3 TAT (show TAT Proteins) fusion protein can inhibit miR (show MLXIP Proteins)-155 expression
LIFR signaling usually follows the JAK (show JAK3 Proteins)/STAT3 (show STAT3 Proteins) pathway, and is initiated by several interleukin-6 (show IL6 Proteins)-type cytokines
R28E mutation in CNTF (show CNTF Proteins) abrogatesIL-6 receptor-dependent but retains CNTF (show CNTF Proteins) receptor-dependent signaling via glycoprotein 130 (show IL6ST Proteins)/ LIFR.
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5\;8)(p13\;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
, LIF receptor
, leukemia inhibitory factor receptor alpha chain
, soluble differentiation-stimulating factor receptor
, CD118 antigen
, leukemia inhibitory factor receptor
, leukemia inhibitor factor receptor alpha-chain
, cytokine receptor-beta