Browse our PTPN11 (PTPN11) ELISA Kits

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Protein tyrosine Phosphatase, Non-Receptor Type 11 ELISA Kits (PTPN11)
On are 24 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) ELISA Kits from 10 different suppliers available. Additionally we are shipping PTPN11 Antibodies (361) and PTPN11 Proteins (10) and many more products for this protein. A total of 409 PTPN11 products are currently listed.
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all ELISA KIts Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

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More ELISA Kits for PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. The data presented in the current study reveal that intestinal serotonin transporter (SERT (show SLC6A4 ELISA Kits)) is a target of the tyrosine phosphatase SHP2 and show a novel mechanism by which a common diarrheagenic pathogen, EPEC, activates cellular SHP2 to inhibit SERT (show SLC6A4 ELISA Kits) function.

  2. The effects of SHP2 overexpression and inhibition on fibroblast response to profibrotic stimuli were analyzed in in primary human fibroblasts. SHP2 was down-regulated and lung fibroblasts obtained from patients with IPF, revealing SHP2 was absent within fibroblastic foci sufficient to induce fibroblast-to-myofibroblast differentiation in primary human lung fibroblasts, resulting in reduced cell survival.

  3. PTPN11 variant was identified in a case with a lethal presentation of Noonan syndrome.

  4. our results provide strong evidence that CD244 (show CD244 ELISA Kits) co-operates with c-Kit (show KIT ELISA Kits) to regulate leukemogenesis through SHP-2/p27 (show PAK2 ELISA Kits) signaling.

  5. SHP2, SOCS3 (show SOCS3 ELISA Kits) and PIAS3 (show PIAS3 ELISA Kits) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 ELISA Kits) downregulation is more reversely correlated with STAT3 (show STAT3 ELISA Kits) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 ELISA Kits) downregulation and decreased incidence of STAT3 (show STAT3 ELISA Kits) nuclear translocation, PIAS3 (show PIAS3 ELISA Kits) is upregulated, the SHP2 level remains unchanged and SOCS3 (show SOCS3 ELISA Kits) is downregulated.

  6. SHP2-ERK2 (show MAPK1 ELISA Kits) signaling acts upstream of C/EBPalpha (show CEBPA ELISA Kits) as a regulator of cell surface I antigen synthesis.

  7. could promote hepatocellular carcinoma cell dedifferentiation and liver cancer stem cell expansion by amplifying beta-catenin (show CTNNB1 ELISA Kits) signaling

  8. The results revealed that although the expression levels of SOCS1 (show SOCS1 ELISA Kits), SOCS3 (show SOCS3 ELISA Kits) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 (show PIAS3 ELISA Kits) downregulation is more negatively correlated with STAT3 (show STAT3 ELISA Kits) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

  9. In a retroviral transduction/transplantation mouse model, mice transplanted with MLL (show MLL ELISA Kits)/AF10 (show MLLT10 ELISA Kits)(OM-LZ) cells harboring PTPN11(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11(G503A) -induced monocytic leukemia (show KAT6B ELISA Kits) in a shorter latency. Adding PTPN11(G503A) to MLL (show MLL ELISA Kits)/AF10 (show MLLT10 ELISA Kits) affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression.

  10. Shp2 (Src (show SRC ELISA Kits)-homology 2 domain-containing phosphatase 2) functions as a negative regulator for STAT3 (show STAT3 ELISA Kits) transcription factor (Stat3 (show STAT3 ELISA Kits)) activation in esophageal squamous cell cancer (ESCC).

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 ELISA Kits), beta-catenin (show CTNNB1 ELISA Kits), and p190RhoGAP (show GRLF1 ELISA Kits) and the activity of RhoA (show RHOA ELISA Kits).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. The effects of SHP2 overexpression and inhibition on fibroblast response to profibrotic stimuli were analyzed in in the bleomycin model of lung fibrosis by SHP2-lentiviral administration in transgenic mice carrying a constitutively active SHP2 mutation. Mice carrying the Noonan syndrome-associated SHP2 mutation were resistant bleomycin induced pulmonary fibrosis.

  2. Data show aberrant neuronal activity-induced signaling and regulation of gene expression in protein tyrosine phosphatase (show ACP1 ELISA Kits), non-receptor type 11 (Ptpn11D61Y) mutation and suggest that these deficits contribute to the pathophysiology of cognitive impairments in Noonan syndrome (NS).

  3. This study indicates that Shp2 is required to orchestrate macrophage function and regulate host innate immunity against pulmonary bacterial infection.

  4. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 (show AKT2 ELISA Kits) strongly influences osteoblast differentiation from bone marrow stromal cells.

  5. SHP-2 is functionally important for the maintenance of appropriate barrier function and host-microbiota homeostasis in the large intestine.

  6. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 (show CCL3 ELISA Kits) as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias.

  7. SHP2 is a potential positive regulator of eosinophil differentiation, and inhibition of SHP2 specifically in myeloid cells eventually alleviates eosinophilic airway inflammation.

  8. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  9. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

  10. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

PTPN11 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11) Elisa Kit
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) Elisa Kit
  • 2700084A17Rik Elisa Kit
  • AW536184 Elisa Kit
  • BPTP3 Elisa Kit
  • CFC Elisa Kit
  • NS1 Elisa Kit
  • PTP-1D Elisa Kit
  • PTP1D Elisa Kit
  • PTP2C Elisa Kit
  • SAP-2 Elisa Kit
  • SH-PTP2 Elisa Kit
  • SH-PTP3 Elisa Kit
  • SHP-2 Elisa Kit
  • Shp2 Elisa Kit
  • SYP Elisa Kit

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
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