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Browse our PTPN11 (PTPN11) ELISA Kits

Full name:
Protein tyrosine Phosphatase, Non-Receptor Type 11 ELISA Kits (PTPN11)
On www.antibodies-online.com are 24 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) ELISA Kits from 8 different suppliers available. Additionally we are shipping PTPN11 Antibodies (369) and PTPN11 Proteins (12) and many more products for this protein. A total of 420 PTPN11 products are currently listed.
Synonyms:
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all ELISA KIts Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

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More ELISA Kits for PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. mutation in PTPN11 is associated with co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome.

  2. The existence of a tight association between SHP2 and EGFR (show EGFR ELISA Kits) expression in tumors and cell lines further suggested the importance of SHP2 in EGFR (show EGFR ELISA Kits) expression.

  3. patients with low Shp2 expression exhibited superior prognosis to sorafenib

  4. Combined X-ray crystallography, small-angle X-ray scattering, and biochemistry to elucidate structural and mechanistic features of three cancer-associated SHP2 variants with single point mutations within the N-SH2:PTP interdomain autoinhibitory interface.

  5. In vitro assays suggested that LEOPARD syndrome-associated SHP-2 mutations might enhance melanin synthesis in melanocytes, and that the activation of Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signalling may contribute to this process.

  6. SHP2 may promote invadopodia formation through inhibition of Rho signaling in cancer cells.

  7. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3 (show F2RL2 ELISA Kits)/PAR6 (show PARD6A ELISA Kits)/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition

  8. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

  9. SHP2 preferentially binds to and dephosphorylates Ras to increase its association with Raf and (show HRAS ELISA Kits)activate downstream proliferative Ras/ERK/MAPK signaling.

  10. Data show that SNP interactions among H. pylori-related genes PGC (show PGC ELISA Kits), PTPN11, and IL1B (show IL1B ELISA Kits), are associated with susceptibility to gastric carcinogenesis.

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 ELISA Kits), beta-catenin (show CTNNB1 ELISA Kits), and p190RhoGAP (show GRLF1 ELISA Kits) and the activity of RhoA (show RHOA ELISA Kits).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  2. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

  3. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

  4. SHP2 activity is elevated in astrocytes isolated from glioblastoma multiforme (GBM)-prone H-Ras (show HRAS ELISA Kits)(12V) knock-in mice.

  5. find that Shp2 is distributed to the kinetochore, centrosome, spindle midzone, and midbody

  6. Mouse podocytes lacking Shp2 do not develop foot process spreading when subjected to podocyte injury in vivo using protamine sulfate or nephrotoxic serum.

  7. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.

  8. Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

  9. SHP2 silencing in P815 mouse mastocytoma cell line harboring KITD814Y mutation results in impaired signaling to ERK (show EPHB2 ELISA Kits), Btk (show BTK ELISA Kits), Lyn (show LYN ELISA Kits) and STAT5 (show STAT5A ELISA Kits) pathways, and reduced rates of cell growth and colony formation.

  10. Shp2 regulates IEC homeostasis through activation of Ras and thereby protects against the development of colitis.

PTPN11 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11) Elisa Kit
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) Elisa Kit
  • 2700084A17Rik Elisa Kit
  • AW536184 Elisa Kit
  • BPTP3 Elisa Kit
  • CFC Elisa Kit
  • NS1 Elisa Kit
  • PTP-1D Elisa Kit
  • PTP1D Elisa Kit
  • PTP2C Elisa Kit
  • SAP-2 Elisa Kit
  • SH-PTP2 Elisa Kit
  • SH-PTP3 Elisa Kit
  • SHP-2 Elisa Kit
  • Shp2 Elisa Kit
  • SYP Elisa Kit

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

GENE ID SPECIES
5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
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