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Browse our PTPN6 Proteins (PTPN6)

Full name:
Protein-tyrosine Phosphatase 1C Proteins (PTPN6)
On are 18 Protein-tyrosine Phosphatase 1C (PTPN6) Proteins from 11 different suppliers available. Additionally we are shipping PTPN6 Antibodies (179) and PTPN6 Kits (12) and many more products for this protein. A total of 220 PTPN6 products are currently listed.
DRPLA, hcp, Hcph, HPTP1C, me, motheaten, PTP-1C, Ptp1C, Ptph6, SH-PTP1, SHP, Shp-1, SHP-1L, SHP1
list all proteins Gene Name GeneID UniProt
PTPN6 23957 Q62227
PTPN6 5777 P29350
PTPN6 116689 P81718

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PTPN6 Proteins (PTPN6) by Origin

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Top referenced PTPN6 Proteins

  1. Human PTPN6 Protein expressed in Escherichia coli (E. coli) - ABIN666674 : Shen, Bastien, Posner, Chrétien: A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. in Nature 1991 (PubMed)
    Show all 2 references for ABIN666674

More Proteins for PTPN6 Interaction Partners

Mouse (Murine) Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. This study reveals SHP (show LAMC1 Proteins) as a global transcriptional partner of SREBP-2 (show SREBF2 Proteins) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Proteins).

  3. The prostate of mev/mev mice exhibits signs of aberrant differentiation and the resulting phenotype may be related to the loss of function of SHP-1. Prostatic anomalies in these mice affect, together with defects in sperm maduration, for their sterility.

  4. These studies reveal critical pathways controlled by SHP-1 in oligodendrocytes that relate to susceptibility of SHP-1-deficient mice to both developmental defects in myelination and to inflammatory demyelinating diseases

  5. Our results suggest that SHP (show LAMC1 Proteins) is required for both antidiabetic and hypolipidemic effects of TZDs in ob/ob mice through regulation of PPARgamma (show PPARG Proteins) expression.

  6. These data are suggestive of a role for SHP (show LAMC1 Proteins) in controlling NLRP3 (show NLRP3 Proteins) inflammasome activation through a mechanism involving interaction with NLRP3 (show NLRP3 Proteins) and maintenance of mitochondrial homeostasis.

  7. SHP-1 regulates Cbl-b-mediated T cell responses by controlling its tyrosine phosphorylation and ubiquitination

  8. The inhibitory activity of SHP-1 is needed for setting the threshold of natural killer cell reactivity.

  9. Shp1 signalling is required for the establishment of a life-long protective humoral immunity.

  10. Shp1 binds and controls PIPKIgamma activity and, thereby, modulates phosphatidylinositol (4,5)-bisphosphate levels and adhesion.

Human Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. A combination of sorafenib and SC-43 is a synergistic SHP-1 agonist duo which reduces tumor size and prolonged survival time.

  3. SHP-1 has a critical role in radioresistance, cell cycle progression, and senescence of nasopharyngeal carcinoma cells

  4. Data demonstrate for the first time that SHP1 methylation has high specificity for diagnosis of endometrial carcinoma, while CDH13 (show CDH13 Proteins) promoter methylation plays a role in the earlier stage.

  5. MiR (show MLXIP Proteins)-378g enhanced radiosensitivity partially by targeting SHP-1 in NPC (show NPC1 Proteins) cells.

  6. Soluble egg antigens glycans are essential for induction of enhanced SOCS1 and SHP1 levels in dendritic cells via the mannose receptor.

  7. miR-4649-3p is downregulated in nasopharyngeal carcinoma cell lines accompanied with SHP-1 upregulation.

  8. Results show that dissociation of SHP-1 from spinophilin (show PPP1R9B Proteins) is followed by an increase in the binding of spinophilin (show PPP1R9B Proteins) to PP1 (show PPA1 Proteins).

  9. Data show that SHP-1 promotes HIF-1alpha degradation under hypoxic conditions leading to a reduction in VEGF synthesis and secretion and impairing epithelial cells proliferation.

  10. Phosphorylation of ATR and CHK1 did not show significant differences in the three cell groups. Overexpression of SHP-1 in the CNE-2 cells led to radioresistance and the radioresistance was related to enhanced DNA DSB repair.

PTPN6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Alternative names and synonyms associated with PTPN6

  • protein tyrosine phosphatase, non-receptor type 6 (PTPN6)
  • nuclear receptor subfamily 0, group B, member 2 (Nr0b2)
  • protein tyrosine phosphatase, non-receptor type 6 (Ptpn6)
  • DRPLA protein
  • hcp protein
  • Hcph protein
  • HPTP1C protein
  • me protein
  • motheaten protein
  • PTP-1C protein
  • Ptp1C protein
  • Ptph6 protein
  • SH-PTP1 protein
  • SHP protein
  • Shp-1 protein
  • SHP-1L protein
  • SHP1 protein

Protein level used designations for PTPN6

nuclear receptor subfamily 0 group B member 2 , orphan nuclear receptor SHP , small heterodimer partner , hematopoietic cell phosphatase , hematopoietic cell protein-tyrosine phosphatase , protein-tyrosine phosphatase 1C , protein-tyrosine phosphatase SHP-1 , tyrosine-protein phosphatase non-receptor type 6 , 70Z-SHP , PTP-1C , PTPTY-42 , SH-PTP1 , hemopoietic cell phosphatase , SH2 phosphatase 1 , dentatorubro-pallidoluysian atrophy protein , non-receptor type protein tyrosine phosphatase SHP1

100052882 Equus caballus
23957 Mus musculus
5777 Homo sapiens
15170 Mus musculus
116689 Rattus norvegicus
486717 Canis lupus familiaris
100171389 Sus scrofa
100723417 Cavia porcellus
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