Browse our PTPN6 Proteins (PTPN6)

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Protein-tyrosine Phosphatase 1C Proteins (PTPN6)
On are 19 Protein-tyrosine Phosphatase 1C (PTPN6) Proteins from 12 different suppliers available. Additionally we are shipping PTPN6 Antibodies (196) and PTPN6 Kits (15) and many more products for this protein. A total of 238 PTPN6 products are currently listed.
DRPLA, hcp, Hcph, HPTP1C, me, motheaten, PTP-1C, Ptp1C, Ptph6, SH-PTP1, SHP, Shp-1, SHP-1L, SHP1
list all proteins Gene Name GeneID UniProt
PTPN6 23957 Q62227
PTPN6 5777 P29350
PTPN6 116689 P81718

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PTPN6 Proteins (PTPN6) by Origin

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Top referenced PTPN6 Proteins

  1. Human PTPN6 Protein expressed in Escherichia coli (E. coli) - ABIN666674 : Shen, Bastien, Posner, Chrétien: A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. in Nature 1991 (PubMed)
    Show all 2 references for 666674

More Proteins for PTPN6 Interaction Partners

Mouse (Murine) Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Proteins) target genes Fgf15 and Shp (show LAMC1 Proteins) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Proteins) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota

  2. SHP (show LAMC1 Proteins) and REV-ERBalpha (show NR1D1 Proteins) play a critical role in controlling rhythmic CHOP (show DDIT3 Proteins) expression in alcoholic fatty liver

  3. Results are consistent with predicted/observed reduction in the Lyn-SHIP-1-PTEN-SHP-1 axis function in B cells from systemic lupus

  4. our results suggest that SHP (show LAMC1 Proteins) upregulation upon high-fat feeding leads to lipid accumulation, insulin (show INS Proteins) resistance and inflammation in cardiomyocytes.

  5. Our data show that SHP1 is required for the survival of mature thymocytes and the generation of the functional T-cell repertoire, as its absence leads to a reduction in the numbers of CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) naive T cells in the peripheral lymphoid compartments.

  6. Our study suggests that metformin exerts its insulin sensitizing effects via inhibition of SHP-1 activity and expression.

  7. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  8. Mortality of SHP (show LAMC1 Proteins)-/- mice after ethanol binge feeding was significantly reduced and Aldh2 (show ALDH2 Proteins) mRNA level was higher. After an intoxicating dose of ethanol, SHP (show LAMC1 Proteins)-/- mice exhibited faster blood ethanol clearance.

  9. Studies indicate that SHP1 and SYK (show SYK Proteins) crosstalk as a critical regulator of MyD88 (show MYD88 Proteins) post-translational modifications and IL-1 (show IL1A Proteins)-driven inflammation.

  10. Our findings uncover an important role for PP6 as an indispensable guardian of genomic integrity of the lengthy prophase I oocyte arrest, maintenance of primordial follicle pool, and thus female fertility.

Human Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. Results provide evidence that repression of SHP-1, SHP-2 (show PTPN11 Proteins) and SOCS-1 (show SOCS1 Proteins) gene expression in patient plasma cells supports the constitutive activation of the JAK (show JAK3 Proteins)/STAT3 (show STAT3 Proteins) pathway and probably leads to higher degrees of bone marrow invasion.

  2. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  3. Hyperglycemia induces SHP-1 promoter epigenetic modifications, causing its persistent expression and activity and leading to insulin (show INS Proteins) resistance, podocyte dysfunction, and DN.

  4. Low SHP1 expression is associated with primary central nervous system lymphoma.

  5. study evaluated SHP1-P2 methylation levels in the lymph nodes of colorectal cancer (CRC) patients; hypothesized that SHP1-P2 methylation levels would be higher in metastatic lymph nodes

  6. Overexpression of SHP1 downregulates the JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) pathway to modulate various target genes and inhibit cell proliferation, migration, and invasion in gastric cancer cells.

  7. This study also found no correlation of SHP-1 expression at diagnosis with response to treatment, although a trend for lower SHP-1 expression was noted in the very small non-responders' group of the 3-month therapeutic milestone.

  8. SYK (show SYK Proteins), LYN (show LYN Proteins) and PTPN6 were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.

  9. cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL (show BCL2L11 Proteins)-Bax (show BAX Proteins) pro-apoptotic cascade in phagocytes.

  10. Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression

PTPN6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Alternative names and synonyms associated with PTPN6

  • protein tyrosine phosphatase, non-receptor type 6 (PTPN6)
  • nuclear receptor subfamily 0, group B, member 2 (Nr0b2)
  • protein tyrosine phosphatase, non-receptor type 6 (Ptpn6)
  • DRPLA protein
  • hcp protein
  • Hcph protein
  • HPTP1C protein
  • me protein
  • motheaten protein
  • PTP-1C protein
  • Ptp1C protein
  • Ptph6 protein
  • SH-PTP1 protein
  • SHP protein
  • Shp-1 protein
  • SHP-1L protein
  • SHP1 protein

Protein level used designations for PTPN6

nuclear receptor subfamily 0 group B member 2 , orphan nuclear receptor SHP , small heterodimer partner , hematopoietic cell phosphatase , hematopoietic cell protein-tyrosine phosphatase , protein-tyrosine phosphatase 1C , protein-tyrosine phosphatase SHP-1 , tyrosine-protein phosphatase non-receptor type 6 , 70Z-SHP , PTP-1C , PTPTY-42 , SH-PTP1 , hemopoietic cell phosphatase , SH2 phosphatase 1 , dentatorubro-pallidoluysian atrophy protein , non-receptor type protein tyrosine phosphatase SHP1

100052882 Equus caballus
23957 Mus musculus
5777 Homo sapiens
15170 Mus musculus
116689 Rattus norvegicus
486717 Canis lupus familiaris
100171389 Sus scrofa
100723417 Cavia porcellus
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