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Browse our PTPN6 Proteins (PTPN6)

Full name:
Protein-tyrosine Phosphatase 1C Proteins (PTPN6)
On are 20 Protein-tyrosine Phosphatase 1C (PTPN6) Proteins from 13 different suppliers available. Additionally we are shipping PTPN6 Antibodies (190) and PTPN6 Kits (14) and many more products for this protein. A total of 232 PTPN6 products are currently listed.
DRPLA, hcp, Hcph, HPTP1C, me, motheaten, PTP-1C, Ptp1C, Ptph6, SH-PTP1, SHP, Shp-1, SHP-1L, SHP1
list all proteins Gene Name GeneID UniProt
PTPN6 23957 Q62227
PTPN6 5777 P29350
PTPN6 116689 P81718

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PTPN6 Proteins (PTPN6) by Origin

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Top referenced PTPN6 Proteins

  1. Human PTPN6 Protein expressed in Escherichia coli (E. coli) - ABIN666674 : Shen, Bastien, Posner, Chrétien: A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. in Nature 1991 (PubMed)
    Show all 2 references for ABIN666674

More Proteins for PTPN6 Interaction Partners

Mouse (Murine) Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency.

  2. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  3. This study reveals SHP (show LAMC1 Proteins) as a global transcriptional partner of SREBP-2 (show SREBF2 Proteins) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Proteins).

  4. The prostate of mev/mev mice exhibits signs of aberrant differentiation and the resulting phenotype may be related to the loss of function of SHP-1. Prostatic anomalies in these mice affect, together with defects in sperm maduration, for their sterility.

  5. These studies reveal critical pathways controlled by SHP-1 in oligodendrocytes that relate to susceptibility of SHP-1-deficient mice to both developmental defects in myelination and to inflammatory demyelinating diseases

  6. Our results suggest that SHP (show LAMC1 Proteins) is required for both antidiabetic and hypolipidemic effects of TZDs in ob/ob mice through regulation of PPARgamma (show PPARG Proteins) expression.

  7. These data are suggestive of a role for SHP (show LAMC1 Proteins) in controlling NLRP3 (show NLRP3 Proteins) inflammasome activation through a mechanism involving interaction with NLRP3 (show NLRP3 Proteins) and maintenance of mitochondrial homeostasis.

  8. SHP-1 regulates Cbl-b-mediated T cell responses by controlling its tyrosine phosphorylation and ubiquitination

  9. The inhibitory activity of SHP-1 is needed for setting the threshold of natural killer cell reactivity.

  10. Shp1 signalling is required for the establishment of a life-long protective humoral immunity.

Human Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. Low SHP1 expression is associated with primary central nervous system lymphoma.

  2. study evaluated SHP1-P2 methylation levels in the lymph nodes of colorectal cancer (CRC) patients; hypothesized that SHP1-P2 methylation levels would be higher in metastatic lymph nodes

  3. Overexpression of SHP1 downregulates the JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) pathway to modulate various target genes and inhibit cell proliferation, migration, and invasion in gastric cancer cells.

  4. This study also found no correlation of SHP-1 expression at diagnosis with response to treatment, although a trend for lower SHP-1 expression was noted in the very small non-responders' group of the 3-month therapeutic milestone.

  5. SYK (show SYK Proteins), LYN (show LYN Proteins) and PTPN6 were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.

  6. cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL (show BCL2L11 Proteins)-Bax (show BAX Proteins) pro-apoptotic cascade in phagocytes.

  7. Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression

  8. N225K and A550V PTPN6 mutations cause loss-of-function leading to JAK3 (show JAK3 Proteins) mediated deregulation of STAT3 (show STAT3 Proteins) pathway and uncover a mechanism that tumor cells can use to control PTPN6 substrate specificity.

  9. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  10. A combination of sorafenib and SC-43 is a synergistic SHP-1 agonist duo which reduces tumor size and prolonged survival time.

PTPN6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Alternative names and synonyms associated with PTPN6

  • protein tyrosine phosphatase, non-receptor type 6 (PTPN6)
  • nuclear receptor subfamily 0, group B, member 2 (Nr0b2)
  • protein tyrosine phosphatase, non-receptor type 6 (Ptpn6)
  • DRPLA protein
  • hcp protein
  • Hcph protein
  • HPTP1C protein
  • me protein
  • motheaten protein
  • PTP-1C protein
  • Ptp1C protein
  • Ptph6 protein
  • SH-PTP1 protein
  • SHP protein
  • Shp-1 protein
  • SHP-1L protein
  • SHP1 protein

Protein level used designations for PTPN6

nuclear receptor subfamily 0 group B member 2 , orphan nuclear receptor SHP , small heterodimer partner , hematopoietic cell phosphatase , hematopoietic cell protein-tyrosine phosphatase , protein-tyrosine phosphatase 1C , protein-tyrosine phosphatase SHP-1 , tyrosine-protein phosphatase non-receptor type 6 , 70Z-SHP , PTP-1C , PTPTY-42 , SH-PTP1 , hemopoietic cell phosphatase , SH2 phosphatase 1 , dentatorubro-pallidoluysian atrophy protein , non-receptor type protein tyrosine phosphatase SHP1

100052882 Equus caballus
23957 Mus musculus
5777 Homo sapiens
15170 Mus musculus
116689 Rattus norvegicus
486717 Canis lupus familiaris
100171389 Sus scrofa
100723417 Cavia porcellus
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