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altered 5-HT4R expression may affect the development of cortical glutamatergic control of the dorsal raphe nucleus.
Results demonstrate that the absence of 5-HT4 receptors triggers adaptive changes that could maintain emotional states, and that the behavioural and molecular effects of fluoxetine under pathological depression appear to be critically dependent on 5-HT4 receptors.
HTR4's role in pulmonary function likely relates to neural innervation and control of breathing.
5-HT4 receptor regulating insulin (show INS Proteins) secretion and acting as a potential drug target in diabetes treatment
The findings of altered lung function and increased AHR (show AHR Proteins) in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies.
Our in vivo data using pharmacologic and genetic approaches suggest that 5-HT(4) receptors are not involved in the bronchial hyperresponsiveness to 5-HT (show DDC Proteins) in cigarette smoke-exposed mice
5-HT (show DDC Proteins) system in the small intestine may play a critical role in regulating circadian rhythms through 5-HT3 (show HTR3A Proteins)/5-HT4-receptor activation.
These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis.
Endogenous 5-HT (show DDC Proteins) exerts a dual role in the pathogenesis of indomethacin-induced intestinal lesions: pro-ulcerogenic action via 5-HT3 (show HTR3A Proteins) receptors and anti-ulcerogenic action via 5-HT4 receptors.
This review presented that the 5HT4 RECEPTOR knockout mice show a correlation between 5-HT (show DDC Proteins) firing rate and depressive/resilience phenotypes.
The 5-HT4 receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR (show AHR Proteins)) to ACh (show FGFR3 Proteins) in guinea-pigs.
Overexpression of G-protein-coupled receptor HTR4 in rod cells affects the glycosylation pattern of coexisting native rhodopsin.
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1 (show TRPV1 Proteins)) agonist capsaicin promotes secondary peristalsis.Esophageal infusion with capsaicin-containing red pepper sauce suspension does create greater mechanosensitivity as measured by secondary peristalsis than 5-HT4 receptor agonist mosapride
Findings replicate our previous observation of a negative association between 5-HT (show DDC Proteins) 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT (show DDC Proteins) 4R binding, as a biomarker for synaptic 5-HT (show DDC Proteins) levels, to the mnestic processing of positive and neutral word stimuli in healthy humans
Results of this study indicated that HTR4 signaling upregulated ERbeta (show ESR2 Proteins) expression in hormone-naive prostate cancer and could impact on biological processes in hormone-naive prostate cancer.
Data suggest that the 5-HT4 receptor is involved in the neurobiological mechanism underlying familial risk for depression, and that lower striatal 5-HT4 receptor binding is associated with increased risk for developing major depression disorder
PDE3A1 and PDE4D3 are integrated into complexes that contain the 5-HT4(b) receptor and may thereby regulate 5-HT4(b) receptor-mediated signaling.
This study demonistrated that 5-hydroxytryptamine (serotonin) receptor 4 regulate memory.
ADAM19 (show Adam19 Proteins) rs1422795 and HTR4 rs11168048 are associated with pulmonary function.
Stimulation of central 5-HT4 receptors is potentially disease-modifying in a transgenic mouse model of Alzheimer's disease.
Taken together, these data suggest a role for HTR4 in lung development, which may at least in part explain the genetic association with lung function.
neurogenic excitatory and inhibitory motor responses and role of 5-HT(4) receptors in circular smooth muscle
The identification of nine novel COOH-terminal splice variants of the porcine 5-HT(4) receptor, is reported.
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
, 5-hydroxytryptamine receptor 4
, serotonin receptor 4
, serotonin 5-HT4 receptor
, cardiac 5-HT4 receptor
, 5 hydroxytryptamine ( serotonin) receptor 4
, 5-HT4 receptor (two splicing variants L and S)
, serotonin 4A receptor (5-HT4A)