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The findings of altered lung function and increased AHR (show AHR Proteins) in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies.
Our in vivo data using pharmacologic and genetic approaches suggest that 5-HT(4) receptors are not involved in the bronchial hyperresponsiveness to 5-HT (show DDC Proteins) in cigarette smoke-exposed mice
5-HT (show DDC Proteins) system in the small intestine may play a critical role in regulating circadian rhythms through 5-HT3 (show HTR3A Proteins)/5-HT4-receptor activation.
These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis.
Endogenous 5-HT (show DDC Proteins) exerts a dual role in the pathogenesis of indomethacin-induced intestinal lesions: pro-ulcerogenic action via 5-HT3 (show HTR3A Proteins) receptors and anti-ulcerogenic action via 5-HT4 receptors.
This review presented that the 5HT4 RECEPTOR knockout mice show a correlation between 5-HT (show DDC Proteins) firing rate and depressive/resilience phenotypes.
These results show that prenatal stress and reduced 5-HT (show DDC Proteins) levels can alter 5-HT(4)R expression in the developing forebrain and that some 5-HT(4)R splice variants.
This study demonistrated that alternatively spliced multiple transcripts of 5-hydroxytryptamine receptor expression in heart.
Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists.
Data indicate that most p11 (show S100A10 Proteins) expressing cells in cerebral cortex, hippocampus, cerebellum, & caudate-putamen express HTR1B (show HTR1B Proteins) or co-express HTR1B (show HTR1B Proteins)/HTR4, suggesting crucial role for p11 (show S100A10 Proteins) in modulating actions of serotonin via these receptor subtypes.
The 5-HT4 receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR (show AHR Proteins)) to ACh (show FGFR3 Proteins) in guinea-pigs.
Overexpression of G-protein-coupled receptor HTR4 in rod cells affects the glycosylation pattern of coexisting native rhodopsin.
analysis of eight bovine 5-HT receptor (show HTR7 Proteins) subtypes in brain, abomasum, and intestine by real-time RT-PCR
Results of this study indicated that HTR4 signaling upregulated ERbeta (show ESR2 Proteins) expression in hormone-naive prostate cancer and could impact on biological processes in hormone-naive prostate cancer.
Data suggest that the 5-HT4 receptor is involved in the neurobiological mechanism underlying familial risk for depression, and that lower striatal 5-HT4 receptor binding is associated with increased risk for developing major depression disorder
PDE3A1 and PDE4D3 are integrated into complexes that contain the 5-HT4(b) receptor and may thereby regulate 5-HT4(b) receptor-mediated signaling.
This study demonistrated that 5-hydroxytryptamine (serotonin) receptor 4 regulate memory.
ADAM19 (show Adam19 Proteins) rs1422795 and HTR4 rs11168048 are associated with pulmonary function.
Stimulation of central 5-HT4 receptors is potentially disease-modifying in a transgenic mouse model of Alzheimer's disease.
Taken together, these data suggest a role for HTR4 in lung development, which may at least in part explain the genetic association with lung function.
Our results suggest that HTR4 polymorphisms may not play a major role in the susceptibility for suicidal behavior in subjects with schizophrenia.
neurogenic excitatory and inhibitory motor responses and role of 5-HT(4) receptors in circular smooth muscle
The identification of nine novel COOH-terminal splice variants of the porcine 5-HT(4) receptor, is reported.
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
, 5-hydroxytryptamine receptor 4
, serotonin receptor 4
, serotonin 5-HT4 receptor
, cardiac 5-HT4 receptor
, 5 hydroxytryptamine ( serotonin) receptor 4
, 5-HT4 receptor (two splicing variants L and S)
, serotonin 4A receptor (5-HT4A)