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Human STAT1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005323
Ungureanu, Vanhatupa, Kotaja, Yang, Aittomaki, Jänne, Palvimo, Silvennoinen: PIAS proteins promote SUMO-1 conjugation to STAT1. in Blood 2003
Show all 4 references for ABIN2005323
Human STAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667813
Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. in Immunity 2010
these results suggest that IL-17 (show IL17A Proteins) intensified IFN-gamma-induced (show SAMHD1 Proteins) NOS2 (show NOS2 Proteins) upregulation and NO production by increasing the transcription activity of p-STAT1(Y701) and NF-kappaB (show NFKB1 Proteins) in RAW 264.7 cells.
5.5-kb upstream regulatory region may provide a regulatory platform for positive feedback control of STAT1 expression.
STAT1 deficiency reprograms IFN signaling from priming toward suppression of TLR response via feedback regulation of STAT3 (show STAT3 Proteins).
The results show that STAT1 expression and activation is upregulated in response to C. muridarum infection in oviduct epithelial cells, and that STAT1 is critical for IFN-beta (show IFNB1 Proteins) production late in infection.
These findings suggest that STAT1-/- adipose tissue does not release glycerol and that free fatty acids (FFA) re-esterify back to triglycerides, thus maintaining fat mass in fasted STAT1-/- mice.
Increased PDGFRbeta signaling promotes advanced plaque formation at novel sites in the thoracic aorta and coronary arteries. However, deletion of STAT1 in VSMCs alleviates inflammation of the arterial wall and reduces plaque burden.
Data indicate that PARP (show PARP1 Proteins) polymerase PARP9-E3 ligase DTX3L (show DTX3L Proteins) interacts with STAT1 transcription factor and enhances translocation of STAT1 to the nucleus.
TLX (show NR2E1 Proteins) has role in regulating STAT1 signaling and host defense
HIV1 Vpr-induced STAT1 activation depends on cyclic guanosine monophosphate-adenosine monophosphate synthase and STING.
our data supports the role of STAT1 in maintaining a tumor-suppressive MG microenvironment.
Our results showed that FAM172A could suppress proliferation of colon cancer cells, and STAT1 could bind to the minimum promoter region of FAM172A and upregulated the expression of FAM172A
Results showed that CD146 (show MCAM Proteins) promoted metastasis of hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells and predicted poor prognosis of HCC (show FAM126A Proteins) patients. CD146 (show MCAM Proteins) induced epithelial mesenchymal transition through probably IL-8 (show IL8 Proteins) up-regulation and STAT1 down-regulation.
Ultraviolet light-emitting-diode irradiation inhibits TNF-alpha (show TNF Proteins) and IFN-gamma-induced (show SAMHD1 Proteins) expression of ICAM-1 (show ICAM1 Proteins) and STAT1 phosphorylation in human keratinocytes.
Data show the induction of signal transducer and activator of transcription (STAT)1 and IFN-stimulated gene 15 protein (ISG15 (show ISG15 Proteins)) in Rickettsia conorii-infected human umbilical vein endothelial cells (HUVECs).
STAT1 activation in association with JAK2 (show JAK2 Proteins) exon 12 mutations.
Increased expression of STAT1 was associated with metastases in Colon Carcinoma.
Interferonstimulated gene factor 3 complex, which consists of STAT1, STAT2 (show STAT2 Proteins) and IRF9 (show IRF9 Proteins), is required for the induction of SAMHD1 (show SAMHD1 Proteins) expression by IFN-alpha (show IFNA Proteins) in SMMC-7721 cells.
Parainfluenza virus 3 therefore interferes with the phosphorylation of Stat1 downstream of the type III interferon receptor (show IFNAR1 Proteins).
Our results provide insights on the losing equilibrium of the regulatory feedback loop between STAT1 and miR (show MLXIP Proteins)-155-5p influencing tumorigenesis.
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.
the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
The tight junction protein ZO-2 (show TJP2 Proteins) is involved in regulation of vascular smooth muscle cells growth control upon vascular injury that is mediated by the transcription factor Stat1.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, HAI-2 related small protein
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 4
, signal transducer and activator of transcription 1
, transcription factor ISGF-3
, activator of transcription
, signal transduction