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Browse our STAT1 Proteins (STAT1)

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Signal Transducer and Activator of Transcription 1, 91kDa Proteins (STAT1)
On are 22 Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Proteins from 13 different suppliers available. Additionally we are shipping STAT1 Antibodies (618) and STAT1 Kits (44) and many more products for this protein. A total of 728 STAT1 products are currently listed.
2010005J02Rik, AA408197, CANDF7, DD6G4-4, dZ182H3.3, H2RSP, IMUP, IMUP-1, IMUP-2, ISGF-3, si:by51f19.1, si:by134g18.2, si:dz73o4.2, si:dz182h3.3, si:dz199m19.1, STAT, STAT1, STAT4, STAT91, XStat1
list all proteins Gene Name GeneID UniProt
STAT1 72275  
Rat STAT1 STAT1 25124  
STAT1 6772 P42224

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STAT1 Proteins (STAT1) by Origin

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Top referenced STAT1 Proteins

  1. Human STAT1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005323 : Ungureanu, Vanhatupa, Kotaja, Yang, Aittomaki, Jänne, Palvimo, Silvennoinen: PIAS proteins promote SUMO-1 conjugation to STAT1. in Blood 2003 (PubMed)
    Show all 4 references for ABIN2005323

  2. Human STAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667813 : Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. in Immunity 2010 (PubMed)

More Proteins for STAT1 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. this study shows that binding motifs for the transcription factors STAT1 and IRF1 (show IRF1 Proteins) are associated with robust and IL-4 (show IL4 Proteins)-resistant responses to IFN-gamma (show IFNG Proteins) in macrophages

  2. Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1, which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1

  3. STAT signaling plays a central role during retinal degeneration in the rd10 (show PDE6B Proteins) mouse model.

  4. Donor interleukin-22 (show IL22 Proteins) and host type I interferon (show IFNA Proteins) signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10 (show CXCL10 Proteins).

  5. OGG1 acts as a STAT1 coactivator and has transcriptional activity in the presence of e (show HIST3H3 Proteins)ndotoxin

  6. critical for IFN-gamma-induced (show SAMHD1 Proteins) Ipr1 (show SP110 Proteins) expression associated with resistance to tuberculosis

  7. these results suggest that IL-17 (show IL17A Proteins) intensified IFN-gamma-induced (show SAMHD1 Proteins) NOS2 (show NOS2 Proteins) upregulation and NO production by increasing the transcription activity of p-STAT1(Y701) and NF-kappaB (show NFKB1 Proteins) in RAW 264.7 cells.

  8. 5.5-kb upstream regulatory region may provide a regulatory platform for positive feedback control of STAT1 expression.

  9. STAT1 deficiency reprograms IFN signaling from priming toward suppression of TLR response via feedback regulation of STAT3 (show STAT3 Proteins).

  10. The results show that STAT1 expression and activation is upregulated in response to C. muridarum infection in oviduct epithelial cells, and that STAT1 is critical for IFN-beta (show IFNB1 Proteins) production late in infection.

Human Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. a novel mechanism of STAT1 gain-of-function triggered by a chronic mucocutaneous candidiasis pathogenic mutation.

  2. Upregulation of STAT1 is associated with chemotherapy response in pancreatic cancer.

  3. Jak (show JAK3 Proteins)/Stat-1 pathway activation only occurs when an active infection has been established in the host macrophage, and it is plausible that the differences in the expression levels of p-tyr701Stat-1 could be due to different survival mechanisms or to differences in bacteria life cycles within macrophages.

  4. EGFR (show EGFR Proteins) Del 19 may promote Fn14 (show TNFRSF12A Proteins) and JAK1 (show JAK1 Proteins)/STAT1 expression in NSCLC.

  5. These results establish that activation of STAT pathway is essential for anti-hepatitis c virus efficacy of IFN-alpha (show IFNA Proteins).

  6. Stratification analyses by gender and HLA-B27 status showed a boundary significant association between two SNPs (rs10975003 and rs10758669) in JAK2 and AAU (P = 0.052 and P = 0.053, resp.). Conclusions. Our results indicated that genetic polymorphisms of the JAK-STAT signaling pathway genes may not be associated with AAU in the Han Chinese population

  7. Reduced SOCS1 (show SOCS1 Proteins) protein levels in systemic lupus erythematosus patients are correlated with enhanced STAT1 activation.

  8. PI3K (show PIK3CA Proteins), NF-kappaB (show NFKB1 Proteins) and STAT1 are involved in the development and progression of bronchial asthma in children.

  9. strudy identified 3 new unrelated cases of Progressive multifocal leukoencephalopathy in patients with GOF STAT1 mutations, including the novel STAT1 mutation, L400Q. These STAT1 mutations caused delayed STAT1 dephosphorylation and enhanced interferon-gamma (show IFNG Proteins)-driven responses

  10. Regression analysis showed that increased left atrial diameter was associated with the expression of RHOA (show RHOA Proteins) and STAT1.

Pig (Porcine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets

  2. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.

  3. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.

  4. Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.

  5. STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.

  6. the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

  7. Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.

  8. Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.

  9. Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.

  10. The tight junction protein ZO-2 (show TJP2 Proteins) is involved in regulation of vascular smooth muscle cells growth control upon vascular injury that is mediated by the transcription factor Stat1.

Cow (Bovine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Proteins) genes in bovine endometrium during estrus cycle and embryo implantation.

  2. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate

  3. results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes

  4. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.

  5. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).

STAT1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT1

  • signal transducer and activator of transcription 1, 91kDa (STAT1)
  • RIKEN cDNA 2200002D01 gene (2200002D01Rik)
  • signal transducer and activator of transcription 1 (Stat1)
  • signal transducer and activator of transcription 1, 91kDa (stat1)
  • signal transducer and activator of transcription 4 (stat4)
  • 2010005J02Rik protein
  • AA408197 protein
  • CANDF7 protein
  • DD6G4-4 protein
  • dZ182H3.3 protein
  • H2RSP protein
  • IMUP protein
  • IMUP-1 protein
  • IMUP-2 protein
  • ISGF-3 protein
  • si:by51f19.1 protein
  • si:by134g18.2 protein
  • si:dz73o4.2 protein
  • si:dz182h3.3 protein
  • si:dz199m19.1 protein
  • STAT protein
  • STAT1 protein
  • STAT4 protein
  • STAT91 protein
  • XStat1 protein

Protein level used designations for STAT1

signal transducer and activator of transcription 1-alpha/beta , HAI-2 related small protein , signal transducer and activator of transcription-1 , transcription factor ISGF-3 components p91/p84 , signal transducer and activator of transcription 4 , signal transducer and activator of transcription 1 , transcription factor ISGF-3 , activator of transcription , signal transduction

100307049 Ovis aries
72275 Mus musculus
20846 Mus musculus
25124 Rattus norvegicus
6772 Homo sapiens
424044 Gallus gallus
488449 Canis lupus familiaris
396655 Sus scrofa
510814 Bos taurus
398324 Xenopus laevis
100343893 Oryctolagus cuniculus
368519 Danio rerio
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