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Browse our STAT1 Proteins (STAT1)

Full name:
Signal Transducer and Activator of Transcription 1, 91kDa Proteins (STAT1)
On are 21 Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Proteins from 12 different suppliers available. Additionally we are shipping STAT1 Antibodies (604) and STAT1 Kits (46) and many more products for this protein. A total of 715 STAT1 products are currently listed.
2010005J02Rik, AA408197, CANDF7, DD6G4-4, dZ182H3.3, H2RSP, IMUP, IMUP-1, IMUP-2, ISGF-3, si:by51f19.1, si:by134g18.2, si:dz73o4.2, si:dz182h3.3, si:dz199m19.1, STAT, STAT1, STAT4, STAT91, XStat1
list all proteins Gene Name GeneID UniProt
STAT1 72275  
Rat STAT1 STAT1 25124  
STAT1 6772 P42224

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STAT1 Proteins (STAT1) by Origin

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Top referenced STAT1 Proteins

  1. Human STAT1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005323 : Ungureanu, Vanhatupa, Kotaja, Yang, Aittomaki, Jänne, Palvimo, Silvennoinen: PIAS proteins promote SUMO-1 conjugation to STAT1. in Blood 2003 (PubMed)
    Show all 4 references for ABIN2005323

  2. Human STAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667813 : Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. in Immunity 2010 (PubMed)

More Proteins for STAT1 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. We found that STAT-1(-/-) MRL lpr (show FAS Proteins) mice, but not IRF-9 (show IRF9 Proteins)(-/-) or IFNAR-2 (show IFNAR2 Proteins)(-/-) mice, developed interstitial nephritis characterized by infiltration with RORgammat-positive lymphocytes, macrophages, and eosinophils. Despite pronounced interstitial kidney disease and abnormal kidney function, STAT-1(-/-) mice had decreased proteinuria, glomerulonephritis, and autoantibody production.

  2. Y37L substitution in STAT1 accounted for high flavivirus susceptibility of a mouse strain.

  3. IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (show IRF9 Proteins)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 and STAT2 (show STAT2 Proteins) than IRF9 (show IRF9 Proteins); and 2) signaling pathways not involving STAT1, STAT2 (show STAT2 Proteins), or IRF9 (show IRF9 Proteins) play a minor role only in mediating IFN-alpha (show IFNA Proteins)-stimulated genes expression in MGCs.

  4. These results demonstrate a novel mechanism by which STAT1 negatively regulates ULK1 (show ULK1 Proteins) expression and autophagy.

  5. a novel negative feedback loop mediated by STAT3 (show STAT3 Proteins)-SOCS3 (show SOCS3 Proteins), which is tightly controlled by SENP1 (show SENP1 Proteins) via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins)), in IFN-gamma (show IFNG Proteins) signaling, is reported.

  6. In a mouse model of spontaneous osteopenia caused by hyperactivation of STAT1/3 signaling downstream of gp130 (gp130 (show LRPPRC Proteins)(Y757F/Y757F)), STAT1 deletion rescued the osteopenic phenotype, indicating a beneficial effect of promoting STAT3 (show STAT3 Proteins) signaling over STAT1 downstream of gp130 (show LRPPRC Proteins) in this low bone mass condition, and this may have therapeutic value.

  7. this study shows that STAT-1 and STAT-3 (show STAT3 Proteins) interplay to regulate indoleamine 2,3-dioxygenase activity and immunosuppression in response to of IL-27 (show IL27 Proteins) in neonatal macrophages

  8. this study shows that binding motifs for the transcription factors STAT1 and IRF1 (show IRF1 Proteins) are associated with robust and IL-4 (show IL4 Proteins)-resistant responses to IFN-gamma (show IFNG Proteins) in macrophages

  9. Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1, which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1

  10. STAT signaling plays a central role during retinal degeneration in the rd10 (show PDE6B Proteins) mouse model.

Human Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. results indicated that USP18 (show USP18 Proteins) modulates the anti-HBV activity of IFN-F via activation of the JAK (show JAK3 Proteins)/STAT signaling pathway in Hepg2.2.15 cells.

  2. nicotine-mediated induction of alpha7 nAChR (show CHRNA7 Proteins) was reduced when E2F1 (show E2F1 Proteins) was depleted and in contrast elevated when STAT1 was depleted by siRNAs.

  3. Data suggest PML (promyelocytic leukemia protein (show PML Proteins)) positively regulates STAT1 and STAT2 (show STAT2 Proteins) isgylation, a ubiquitination-like protein modification; PML (show PML Proteins) exhibits potent angiostatic activity, doing so in part by forming a positive feedforward loop with STAT1/2 and a negative feedback loop with STAT3 (show STAT3 Proteins). (STAT = signal transducer and activator of transcription)

  4. the dual regulation of STAT1 by IKKalpha (show CHUK Proteins) in antiviral signaling suggests a role for IKKalpha (show CHUK Proteins) in the fine-tuning of antiviral signaling in response to non-self RNA.

  5. This study demonstrated the first coiled-coil domain mutation of STAT1 as a genetic cause of autosomal-dominant Mendelian susceptibility to mycobacterial diseases

  6. STAT1 suppression by S100A6 (show S100A6 Proteins) may represent a promising therapeutic target to facilitate reendothelialization in damaged vessels.

  7. Our data demonstrate an important connection between mRNA translation and KRAS tumorigenesis under the control of STAT1, which can determine the susceptibility of KRAS tumors to pharmacologic inhibition of mRNA translation initiation.

  8. study demonstrated that miR (show MLXIP Proteins)-9 could inhibit activation of the NLRP3 (show NLRP3 Proteins) inflammasome and attenuate atherosclerosis-related inflammation, likely through the JAK1 (show JAK1 Proteins)/STAT1 signaling pathway. Therefore, miR (show MLXIP Proteins)-9 may serve as a potential therapeutic target for atherosclerosis.

  9. the deubiquitinase USP2a translocates into the nucleus and binds to pY701-STAT1, and inhibits K48-linked ubiquitination and degradation of pY701-STAT1

  10. Demonstrate STAT1-dependent transcriptional activation of TLR8 (show TLR8 Proteins) with estrogen stimulation.

Pig (Porcine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (show IFNA Proteins) response by inducing STAT1 degradation.

  2. this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets

  3. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.

  4. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.

  5. Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.

  6. STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.

  7. the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

  8. Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.

  9. Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.

  10. Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.

Cow (Bovine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Proteins) genes in bovine endometrium during estrus cycle and embryo implantation.

  2. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate

  3. results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes

  4. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.

  5. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).

STAT1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT1

  • signal transducer and activator of transcription 1, 91kDa (STAT1)
  • RIKEN cDNA 2200002D01 gene (2200002D01Rik)
  • signal transducer and activator of transcription 1 (Stat1)
  • signal transducer and activator of transcription 1, 91kDa (stat1)
  • signal transducer and activator of transcription 4 (stat4)
  • 2010005J02Rik protein
  • AA408197 protein
  • CANDF7 protein
  • DD6G4-4 protein
  • dZ182H3.3 protein
  • H2RSP protein
  • IMUP protein
  • IMUP-1 protein
  • IMUP-2 protein
  • ISGF-3 protein
  • si:by51f19.1 protein
  • si:by134g18.2 protein
  • si:dz73o4.2 protein
  • si:dz182h3.3 protein
  • si:dz199m19.1 protein
  • STAT protein
  • STAT1 protein
  • STAT4 protein
  • STAT91 protein
  • XStat1 protein

Protein level used designations for STAT1

signal transducer and activator of transcription 1-alpha/beta , HAI-2 related small protein , signal transducer and activator of transcription-1 , transcription factor ISGF-3 components p91/p84 , signal transducer and activator of transcription 4 , signal transducer and activator of transcription 1 , transcription factor ISGF-3 , activator of transcription , signal transduction

100307049 Ovis aries
72275 Mus musculus
20846 Mus musculus
25124 Rattus norvegicus
6772 Homo sapiens
424044 Gallus gallus
488449 Canis lupus familiaris
396655 Sus scrofa
510814 Bos taurus
398324 Xenopus laevis
100343893 Oryctolagus cuniculus
368519 Danio rerio
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