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Results showed that the mRNA expression of STAT1 increased during the early stage of adipogenesis under the regulation of Bcl6 (show BCL6 Proteins).
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (show NFkBP65 Proteins), ERK1 (show MAPK3 Proteins), ERK2 (show MAPK1 Proteins) and STAT1 pathways.
The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.
selective knockdown of TNFR5 ameliorates glucolipotoxic induction of STAT1 expression and NF-kappaB (show NFKB1 Proteins) activity.
Treatment of the haplotype Npr1 (show NPR1 Proteins)(+/-) mice with histone deacetylase (show HDAC1 Proteins) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Proteins)/2, NF-kappaB (show NFKB1 Proteins) (p65 (show NFkBP65 Proteins)), and STAT1.
PHLPP1 reduced IFN-gamma (show IFNG Proteins)-stimulated but not LPS (show TLR4 Proteins)-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-gamma-induced (show SAMHD1 Proteins) ser (show SIGLEC1 Proteins)(727) STAT1 phosphorylation and iNOS (show NOS2 Proteins) expression.
Data demonstrate that STAT1 is a key orchestrator of cytokine-producing innate lymphoid cells responses during viral infection via ILC (show CCL27 Proteins)-extrinsic regulation of IL-33 (show IL33 Proteins) and IL-23 (show IL23A Proteins).
NKLAM is a positive regulator of STAT1-mediated transcriptional activity and is an important component of the innate immune response.
In cultured macrophages, LPS (show TLR4 Proteins)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (show NFKBIZ Proteins) activities.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (show MAPK14 Proteins), AAT (show SERPINA1A Proteins), signal transducer and activator of transcription 1 (STAT1) and activating transcription factor2 (ATF2 (show ATF2 Proteins))
Taken together, these findings enabled us to identify a novel mechanism by which eEF1A1 (show EEF1A1 Proteins) regulates the cell cycle's G1 phase to promote tumor proliferation by regulating cyclin D1 (show CCND1 Proteins) expression through STAT1 signaling in HCC (show FAM126A Proteins).
presentation of the two different cases of a patient and her mother with STAT1 GOF mutations having the occurrence of intracranial aneurysms in common
IL-27 (show IL27 Proteins) stimulation activated STAT1 and STAT3 (show STAT3 Proteins) in HeLa and T98G cells, suggesting that IL-27 (show IL27 Proteins) engages the STAT1/3 pathway, which then leads to the upregulation of IL-6 (show IL6 Proteins), IP-10 (show CXCL10 Proteins), and MIG (show CXCL9 Proteins)
Type-I IFN treatment triggers the interaction of STAT1 with SLFN5 (show SLFN5 Proteins), and the resulting complex negatively controls STAT1-mediated gene transcription via interferon (show IFNA Proteins) stimulated response elements
Results show that the amino acids of STAT1 interacting with the DNA primarily determine the specificity of the proteins.
In this review, we summarize recent progress on the function and regulation of STAT1 in both cancer and insulin (show INS Proteins) resistance diseases. Drugs and small molecules that can interfere with STAT1 activity or expression are also discussed
this study shows that the IFN-beta (show IFNB1 Proteins)/STAT1 pathway is dysregulated in inflammatory bowel disease
MACC1 (show MACC1 Proteins) regulates Fas (show FAS Proteins) mediated apoptosis through STAT1/3 - Mcl-1 (show MCL1 Proteins) signaling in solid cancers.
the phosphorylation of signal transducer and activator of transcription 1 (STAT1-py) was impaired in asthmatics, whereas the phosphorylation of signal transducer and activator of transcription 6 (STAT6 (show STAT6 Proteins)-py) was slightly enhanced.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (show IFNA Proteins) response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.
the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Proteins) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, HAI-2 related small protein
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 4
, signal transducer and activator of transcription 1
, transcription factor ISGF-3
, activator of transcription
, signal transduction