Browse our STAT1 Proteins (STAT1)

Full name:
Signal Transducer and Activator of Transcription 1, 91kDa Proteins (STAT1)
On www.antibodies-online.com are 21 Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Proteins from 12 different suppliers available. Additionally we are shipping STAT1 Antibodies (635) and STAT1 Kits (46) and many more products for this protein. A total of 747 STAT1 products are currently listed.
Synonyms:
2010005J02Rik, AA408197, CANDF7, DD6G4-4, dZ182H3.3, H2RSP, IMUP, IMUP-1, IMUP-2, ISGF-3, si:by51f19.1, si:by134g18.2, si:dz73o4.2, si:dz182h3.3, si:dz199m19.1, STAT, STAT1, STAT4, STAT91, XStat1
list all proteins Gene Name GeneID UniProt
STAT1 72275  
Rat STAT1 STAT1 25124  
STAT1 6772 P42224

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STAT1 Proteins (STAT1) by Origin

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Top referenced STAT1 Proteins

  1. Human STAT1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005323 : Ungureanu, Vanhatupa, Kotaja, Yang, Aittomaki, Jänne, Palvimo, Silvennoinen: PIAS proteins promote SUMO-1 conjugation to STAT1. in Blood 2003 (PubMed)
    Show all 4 references for 2005323

  2. Human STAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667813 : Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. in Immunity 2010 (PubMed)

More Proteins for STAT1 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Data demonstrate that STAT1 is a key orchestrator of cytokine-producing innate lymphoid cells responses during viral infection via ILC (show CCL27 Proteins)-extrinsic regulation of IL-33 (show IL33 Proteins) and IL-23 (show IL23A Proteins).

  2. NKLAM is a positive regulator of STAT1-mediated transcriptional activity and is an important component of the innate immune response.

  3. In cultured macrophages, LPS (show TLR4 Proteins)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (show NFKBIZ Proteins) activities.

  4. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (show MAPK14 Proteins), AAT (show SERPINA1A Proteins), signal transducer and activator of transcription 1 (STAT1) and activating transcription factor2 (ATF2 (show ATF2 Proteins))

  5. This secreted effector, toxoplasma inhibitor of STAT1-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2 (show CHD4 Proteins)/NuRD to STAT1-dependent promoters, resulting in altered chromatin and blocked transcription.

  6. Microbiome depletion as a result of broad-spectrum antibiotic treatment disrupts basal Stat1 signaling and alters T-cell homeostasis, leading to impaired progenitor maintenance and granulocyte maturation.

  7. We revealed that in mouse mesenchymal stem cells IFN-gamma-induced (show SAMHD1 Proteins) immunoregulation is mediated by early phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT3 (show STAT3 Proteins), which is significantly enhanced by an extracellular signal-regulated kinase 1/2 (show MAPK3 Proteins)-dependent mTOR (show FRAP1 Proteins) inhibition, thereby promoting pSTAT1 nuclear translocation.

  8. these results define a differential regulation of TLR-mediated activation and differentiation of MZ B cells by STAT1 and reveal a STAT1-dependent, but IFN-independent, antibody response during infection and inflammation.

  9. B cell-intrinsic IFN-gamma (show IFNG Proteins) receptor (IFN-gammaR (show IFNGR1 Proteins)) and STAT1 signaling are required for Spontaneously developed germinal centers and follicular T helper cell (Tfh cell) development.

  10. Inhibitor-sensitive tyrosine kinase (show TYRO3 Proteins) controls the population heterogeneity of basal STAT1 activity in Ube1l (show UBA7 Proteins) deficient fibroblasts.

Human Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. MACC1 (show MACC1 Proteins) regulates Fas (show FAS Proteins) mediated apoptosis through STAT1/3 - Mcl-1 (show MCL1 Proteins) signaling in solid cancers.

  2. the phosphorylation of signal transducer and activator of transcription 1 (STAT1-py) was impaired in asthmatics, whereas the phosphorylation of signal transducer and activator of transcription 6 (STAT6 (show STAT6 Proteins)-py) was slightly enhanced.

  3. MFSD2B, CCL20 (show CCL20 Proteins) and STAT1, or STARD7 (show STARD7 Proteins) and ZNF512 genes may be risk or protect factors in prognosis of ADC (show ADC Proteins); HTR2B (show HTR2B Proteins), DPP4 (show DPP4 Proteins), and TGFBRAP1 (show TGFBRAP1 Proteins) genes may be risk factors in prognosis of SQC (show QPCT Proteins).

  4. In cultured macrophages, LPS (show IRF6 Proteins)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CCL2 Proteins) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (show NFKBIZ Proteins) activities.

  5. Functional analysis of NK cells shows a significant impairment of cytolytic and degranulation activities in chronic mucocutaneous candidiasis patients with STAT1 GOF mutations

  6. Mechanistic investigations reveal that AJUBA (show AJUBA Proteins) specifically binds the FERM domain of JAK1 (show JAK1 Proteins) to dissociate JAK1 (show JAK1 Proteins) from the IFNgamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (show AJUBA Proteins) in CRC (show CALR Proteins) specimens is negatively correlated with the levels of IFIT2 (show IFIT2 Proteins) and pSTAT1

  7. Low STAT1 expression is associated with Pancreatic cancer.

  8. STAT1 and IRF1 (show IRF1 Proteins) collaborate to induce interferon-gamma (show IFNG Proteins) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 and IRF1 (show IRF1 Proteins) at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.

  9. IFITM1 (show IFITM1 Proteins) suppression blocks proliferation and invasion of aromatase (show CYP19A1 Proteins) inhibitor-resistant breast cancer in vivo by JAK (show JAK3 Proteins)/STAT1-mediated induction of p21 (show CDKN1A Proteins).

  10. This study reports a new role for SETD2 in promoting IFNalpha-induced antiviral immune response by directly methylating STAT1 on lysine 525 and catalyzing H3K36me3 on the promoters of some IFN-stimulated genes (ISGs such as ISG15) to activate gene transcription. Thus, SETD2 enhances host antiviral immunity by strengthening IFNalpha signaling both post-translationally and epigenetically.

Pig (Porcine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (show IFNA Proteins) response by inducing STAT1 degradation.

  2. this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets

  3. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.

  4. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.

  5. Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.

  6. STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.

  7. the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

  8. Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.

  9. Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.

  10. Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.

Cow (Bovine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Proteins) genes in bovine endometrium during estrus cycle and embryo implantation.

  2. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate

  3. results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes

  4. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.

  5. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).

STAT1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT1

  • signal transducer and activator of transcription 1, 91kDa (STAT1)
  • RIKEN cDNA 2200002D01 gene (2200002D01Rik)
  • signal transducer and activator of transcription 1 (Stat1)
  • signal transducer and activator of transcription 1, 91kDa (stat1)
  • signal transducer and activator of transcription 4 (stat4)
  • 2010005J02Rik protein
  • AA408197 protein
  • CANDF7 protein
  • DD6G4-4 protein
  • dZ182H3.3 protein
  • H2RSP protein
  • IMUP protein
  • IMUP-1 protein
  • IMUP-2 protein
  • ISGF-3 protein
  • si:by51f19.1 protein
  • si:by134g18.2 protein
  • si:dz73o4.2 protein
  • si:dz182h3.3 protein
  • si:dz199m19.1 protein
  • STAT protein
  • STAT1 protein
  • STAT4 protein
  • STAT91 protein
  • XStat1 protein

Protein level used designations for STAT1

signal transducer and activator of transcription 1-alpha/beta , HAI-2 related small protein , signal transducer and activator of transcription-1 , transcription factor ISGF-3 components p91/p84 , signal transducer and activator of transcription 4 , signal transducer and activator of transcription 1 , transcription factor ISGF-3 , activator of transcription , signal transduction

GENE ID SPECIES
100307049 Ovis aries
72275 Mus musculus
20846 Mus musculus
25124 Rattus norvegicus
6772 Homo sapiens
424044 Gallus gallus
488449 Canis lupus familiaris
396655 Sus scrofa
510814 Bos taurus
398324 Xenopus laevis
100343893 Oryctolagus cuniculus
368519 Danio rerio
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