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Human STAT1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005323
Ungureanu, Vanhatupa, Kotaja, Yang, Aittomaki, Jänne, Palvimo, Silvennoinen: PIAS proteins promote SUMO-1 conjugation to STAT1. in Blood 2003
Show all 4 references for ABIN2005323
Human STAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667813
Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. in Immunity 2010
Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1, which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1
STAT signaling plays a central role during retinal degeneration in the rd10 (show PDE6B Proteins) mouse model.
Donor interleukin-22 (show IL22 Proteins) and host type I interferon (show IFNA Proteins) signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10 (show CXCL10 Proteins).
OGG1 acts as a STAT1 coactivator and has transcriptional activity in the presence of e (show HIST3H3 Proteins)ndotoxin
critical for IFN-gamma-induced (show SAMHD1 Proteins) Ipr1 (show SP110 Proteins) expression associated with resistance to tuberculosis
these results suggest that IL-17 (show IL17A Proteins) intensified IFN-gamma-induced (show SAMHD1 Proteins) NOS2 (show NOS2 Proteins) upregulation and NO production by increasing the transcription activity of p-STAT1(Y701) and NF-kappaB (show NFKB1 Proteins) in RAW 264.7 cells.
5.5-kb upstream regulatory region may provide a regulatory platform for positive feedback control of STAT1 expression.
STAT1 deficiency reprograms IFN signaling from priming toward suppression of TLR response via feedback regulation of STAT3 (show STAT3 Proteins).
The results show that STAT1 expression and activation is upregulated in response to C. muridarum infection in oviduct epithelial cells, and that STAT1 is critical for IFN-beta (show IFNB1 Proteins) production late in infection.
These findings suggest that STAT1-/- adipose tissue does not release glycerol and that free fatty acids (FFA) re-esterify back to triglycerides, thus maintaining fat mass in fasted STAT1-/- mice.
Reduced SOCS1 (show SOCS1 Proteins) protein levels in systemic lupus erythematosus patients are correlated with enhanced STAT1 activation.
PI3K (show PIK3CA Proteins), NF-kappaB (show NFKB1 Proteins) and STAT1 are involved in the development and progression of bronchial asthma in children.
strudy identified 3 new unrelated cases of Progressive multifocal leukoencephalopathy in patients with GOF STAT1 mutations, including the novel STAT1 mutation, L400Q. These STAT1 mutations caused delayed STAT1 dephosphorylation and enhanced interferon-gamma (show IFNG Proteins)-driven responses
Regression analysis showed that increased left atrial diameter was associated with the expression of RHOA (show RHOA Proteins) and STAT1.
Foot-and-mouth disease virus VP3 interacted with JAK1 (show JAK1 Proteins)/2, degraded JAK1 (show JAK1 Proteins), and inhibited the tyrosine phosphorylation, dimerization and nuclear accumulation of STAT1.
remodeling by acetylation and dimethylation of lysine-14 and -4 residues of histone H3 (show HIST3H3 Proteins). In addition, OGG1 (show OGG1 Proteins) acts as a STAT1 coactivator and has transcriptional activity in the presence of endotoxin. The data presented here identifies a novel mechanism, and may provide new therapeutic strategies for the treatment of endotoxin-mediated inflammatory diseases.
These data thus suggest that overexpression of SOCS1 (show SOCS1 Proteins) and SOCS3 (show SOCS3 Proteins) induced by denguevirus infection leads to impairment of antiviral response through the inhibition of STAT functionality.
Stable isotope labeling by amino acids in cell culture (SILAC) was applied to analyze the STAT1 interactome after streptavidin pull-down of biotagged STAT1 from human embryonic kidney 293T cells with and without activation. Starting from more than 2,000 captured proteins 30 potential STAT1 interaction partners were extracted
findings suggest that PRMT1 (show PRMT1 Proteins) is a central regulator of tissue remodeling and that the signaling sequence controlling its expression in primary human lung fibroblast is PDGF (show PDGFA Proteins)-ERK (show EPHB2 Proteins)-STAT1.
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.
the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
The tight junction protein ZO-2 (show TJP2 Proteins) is involved in regulation of vascular smooth muscle cells growth control upon vascular injury that is mediated by the transcription factor Stat1.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, HAI-2 related small protein
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 4
, signal transducer and activator of transcription 1
, transcription factor ISGF-3
, activator of transcription
, signal transduction