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Browse our STAT4 Proteins (STAT4)

Full name:
Signal Transducer and Activator of Transcription 4 Proteins (STAT4)
On are 8 Signal Transducer and Activator of Transcription 4 (STAT4) Proteins from 7 different suppliers available. Additionally we are shipping STAT4 Antibodies (280) and STAT4 Kits (41) and many more products for this protein. A total of 348 STAT4 products are currently listed.
list all proteins Gene Name GeneID UniProt
STAT4 6775 Q14765
STAT4 20849 P42228
Rat STAT4 STAT4 367264  

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STAT4 Proteins (STAT4) by Origin

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Human Signal Transducer and Activator of Transcription 4 (STAT4) interaction partners

  1. Five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 (show HLA-DRB1 Proteins) and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC.

  2. There is a significant association between STAT4 rs7574865 polymorphism and IBD susceptibility in overall population.

  3. STAT4 protein genetic variation is a prognostic factor predicting the treatment with interferon-alpha (show IFNA Proteins) therapy in chronic hepatitis B.

  4. the presence of the rs7574865 T allele enhances STAT4 mRNA transcription and protein expression

  5. STAT4 rs7574865 polymorphism may be associated with significantly reduced risk of HBV-induced HCC (show FAM126A Proteins) in Asian

  6. gene polymorphisms along with Ptpn22 (show PTPN22 Proteins) polymorphism confers susceptibility to rheumatoid arthritis in all major ethnic groups. [meta-analysis]

  7. Significant association with alleles of two STAT4 markers and nominal association of Autoimmune Addison's disease with alleles at GATA3 (show GATA3 Proteins), is reported.

  8. our replication study showed that the rs7574865 in STAT4 and rs9275319 in HLA-DQ were not associated with CHB-related HCC (show FAM126A Proteins) in a Korean population.

  9. CCR1, KLRC4 (show KLRC4 Proteins), IL12A (show IL12A Proteins)-AS1 (show PTGDR Proteins), STAT4, and ERAP1 (show ERAP1 Proteins) are bona fide susceptibility genes for Behcet's disease.

  10. STAT4 rs7574865 G/T and PTPN22 (show PTPN22 Proteins) rs2488457 G/C polymorphisms as susceptibility factors for JIA

Mouse (Murine) Signal Transducer and Activator of Transcription 4 (STAT4) interaction partners

  1. STAT4 has a pro-atherogenic role that is at least partially independent of Th1 (show HAND1 Proteins) cell-derived interferon-gamma (show IFNG Proteins)

  2. Modulation of IL-12 (show IL12A Proteins)/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes

  3. This study found that stathmin (show STMN1 Proteins) plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin (show STMN1 Proteins) mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory

  4. STAT4 controls GM-CSF (show CSF2 Proteins) production by both Th1 (show HAND1 Proteins) and Th17 cells during experimental autoimmune encephalomyelitis.

  5. Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri (show POSTN Proteins)-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.

  6. T-bet- and STAT4-dependent IL-33 (show IL33 Proteins) receptor expression have roles in directly promoting antiviral Th1 (show HAND1 Proteins) cell responses

  7. Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma (show IFNG Proteins) and CD25 (show IL2RA Proteins) induction through STAT4-independent pathways.

  8. STAT4 appears to be a critical transcription factor in defense against mycobacterial infection

  9. STAT4 deficiency protects against neointima formation following arterial injury in mice.

  10. IL-12 (show IL12A Proteins) drives small airway remodeling via STAT4 signaling.

Cow (Bovine) Signal Transducer and Activator of Transcription 4 (STAT4) interaction partners

  1. These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.

STAT4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with STAT4

  • signal transducer and activator of transcription 4 (STAT4)
  • signal transducer and activator of transcription 4 (stat4)
  • signal transducer and activator of transcription 4 (Stat4)
  • SLEB11 protein

Protein level used designations for STAT4

signal transducer and activator of transcription 4

100054693 Equus caballus
100380385 Salmo salar
100617910 Monodelphis domestica
6775 Homo sapiens
20849 Mus musculus
367264 Rattus norvegicus
768406 Gallus gallus
478845 Canis lupus familiaris
397261 Sus scrofa
515988 Bos taurus
100344146 Oryctolagus cuniculus
100726892 Cavia porcellus
101117562 Ovis aries
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