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This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-alpha (show IFNA Proteins)/beta signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells.
A higher risk to develop RA was observed for rs7574865 in the STAT-4 gene, while the rs1800872 in the IL-10 (show IL10 Proteins) gene showed a protective effect.
STAT4 rs7574865 polymorphism has a role in rheumatoid arthritis and disease activity, but not in anti-CCP (show CRYGD Proteins) antibody levels in a Mexican population
this study shows that STAT4 single nucleotide polymorphism affects clinical outcomes of pediatric acute leukemia patients after hematopoietic stem cell transplant
this study shows that STAT4 gene polymorphisms are associated with ankylosing spondylitis in Southwest China
Our results for the first time showed a significant association between STAT4 rs7582694 alleles and genotypes and susceptibility to endometriosis in a population.
we can conclude that STAT4-rs7574865 polymorphism is clearly associated with the risk of Rheumatoid Arthritis in the Western Algerian population
The results demonstrated that STAT4 rs7574865 and IRF5 (show IRF5 Proteins) rs2004640G/T substitution are associated with a susceptibility to systemic sclerosis.
Our findings indicate that although STAT4 and IFIH1 (show IFIH1 Proteins) SNPs are not associated with T1D in a Brazilian population, they might play a role in susceptibility to T1D on a larger worldwide scale
SNP rs7574865 in STAT4 might contribute to progression to Hepatocellular Carcinoma.
STAT4 has a pro-atherogenic role that is at least partially independent of Th1 (show HAND1 Proteins) cell-derived interferon-gamma (show IFNG Proteins)
Modulation of IL-12 (show IL12A Proteins)/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes
This study found that stathmin (show STMN1 Proteins) plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin (show STMN1 Proteins) mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory
STAT4 controls GM-CSF (show CSF2 Proteins) production by both Th1 (show HAND1 Proteins) and Th17 cells during experimental autoimmune encephalomyelitis.
Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri (show POSTN Proteins)-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.
T-bet- and STAT4-dependent IL-33 (show IL33 Proteins) receptor expression have roles in directly promoting antiviral Th1 (show HAND1 Proteins) cell responses
Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma (show IFNG Proteins) and CD25 (show IL2RA Proteins) induction through STAT4-independent pathways.
STAT4 appears to be a critical transcription factor in defense against mycobacterial infection
STAT4 deficiency protects against neointima formation following arterial injury in mice.
IL-12 (show IL12A Proteins) drives small airway remodeling via STAT4 signaling.
These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
signal transducer and activator of transcription 4