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STAT4 rs7574865G/T polymorphism is associated with rheumatoid arthritis and systemic lupus erythematosus in Mexican women
Results found that activated STAT4 was overexpressed in epithelial cells of ovarian cancer and provide evidence that it promotes ovarian cancer metastasis via tumor-derived Wnt7a (show WNT7A Proteins)-induced activation of cancer-associated fibroblasts.
STAT4 rs7574865 gene polymorphism is associated with the susceptibility of primary biliary cirrhosis in the Han population of Jiangsu province.
The findings results confirm the important role of STAT4 gene in the predisposition to Systemic sclerosis and its phenotypes, such as the presence of Interstitial Lung disease , cardiac injury , and seropositivity for anti-topoisomerase I (show TOP1 Proteins) antibodies in the Russian population.
results show specific and dominant contribution of STAT4 in the hematopoietic compartment to metabolic health and inflammation in diet-induced obesity.
reported that SNPs in STAT4, PTPN2 (show PTPN2 Proteins), PSORS1C1 (show PSORS1C1 Proteins), and TRAF3IP2 (show TRAF3IP2 Proteins) are associated with response to TNF (show TNF Proteins)-i treatment in RA patients; however, these findings should be validated in a larger population
This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-alpha (show IFNA Proteins)/beta signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells.
A higher risk to develop RA was observed for rs7574865 in the STAT-4 gene, while the rs1800872 in the IL-10 (show IL10 Proteins) gene showed a protective effect.
STAT4 rs7574865 polymorphism has a role in rheumatoid arthritis and disease activity, but not in anti-CCP (show CRYGD Proteins) antibody levels in a Mexican population
this study shows that STAT4 single nucleotide polymorphism affects clinical outcomes of pediatric acute leukemia patients after hematopoietic stem cell transplant
this study shows that STAT4 regulates the CD8 (show CD8A Proteins)(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin (show INS Proteins)-resistant Ldlr (show LDLR Proteins)(-/-) mice
virus-specific effector and memory CD4 (show CD4 Proteins) T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 (show CD4 Proteins) T cells was apparent in mice lacking both transcription factors.
STAT4 has a pro-atherogenic role that is at least partially independent of Th1 (show HAND1 Proteins) cell-derived interferon-gamma (show IFNG Proteins)
Modulation of IL-12 (show IL12A Proteins)/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes
This study found that stathmin (show STMN1 Proteins) plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin (show STMN1 Proteins) mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory
STAT4 controls GM-CSF (show CSF2 Proteins) production by both Th1 (show HAND1 Proteins) and Th17 cells during experimental autoimmune encephalomyelitis.
Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri (show POSTN Proteins)-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.
T-bet- and STAT4-dependent IL-33 (show IL33 Proteins) receptor expression have roles in directly promoting antiviral Th1 (show HAND1 Proteins) cell responses
Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma (show IFNG Proteins) and CD25 (show IL2RA Proteins) induction through STAT4-independent pathways.
STAT4 appears to be a critical transcription factor in defense against mycobacterial infection
These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
signal transducer and activator of transcription 4