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Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody
Data suggest that translokin acts as a key negative regulator in the pathway that drives nuclear import of cyclin D1 (show CCND1 Proteins), thus contributing to prevent pRB (show PGR Proteins) inactivation and to maintain cellular quiescence.
report the identification of four Translokin partners: sorting nexin 6 (show SNX6 Proteins), Ran-binding protein M (show RANBP9 Proteins) and the kinesins KIF3A (show KIF3A Proteins) and KIF3B (show KIF3B Proteins)
Tsp57 protein plays a role in the postmeiotic phase of germ cell differentiation
Data suggest that Cep57 serves as a link with its N-terminus anchored to the centriole or centromatrix and its C-terminus to microtubules.
Cep57 is a mitotic kinetochore component that links the function of the KMN (KNL1/Mis12 (show MIS12 Proteins) complex/Ndc80 (show NDC80 Proteins) complex) network and spindle assembly checkpoint via Mis12 (show MIS12 Proteins) binding and Mad1 (show MXD1 Proteins)-Mad2 (show MAD2L1 Proteins) interaction.
We identified copy number variation (CNV) deletion impacting the exon sequences of CEP57L1 (show CEP57L1 Proteins), present in the affected mother and her affected daughter
Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles.
Data suggest for therapeutic targeting of the FGF-2 (show FGF2 Proteins)/FGFR1 (show FGFR1 Proteins)/CEP57 axis in prostate cancer.
Cep57 acts as a PCM (show PCMT1 Proteins) component through binding to NEDD1 (show NEDD1 Proteins) and is required for spindle microtubule organization and maintenance of spindle pole integrity.
Our findings indicate that these and/or additional functions of CEP57 are crucial for maintaining correct chromosomal number during cell division.
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
, centrosomal protein 57kDa
, cep57-related protein
, Cep57-related protein
, Centrosomal protein of 57 kDa
, centrosomal protein of 57 kDa-like
, centrosomal protein of 57 kDa
, testis-specific protein 57
, FGF2-interacting protein
, proliferation-inducing protein 8