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study proposes that Cep290 and Cep72 in centriolar satellites regulate the ciliary localization of BBS4 (show BBS4 Proteins), which in turn affects assembly and recruitment of the BBSome.
The CEP72 polymorphism can identify adults at increased risk of vincristine-induced peripheral neuropathy
aim of this study was to determine whether the CEP72 rs924607 TT genotype is a useful marker of vincristine neuropathy during induction therapy among Spanish children with B-ALL treated on the LAL (show LIPA Proteins)-SHOP protocols
In this study an inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of vincristine-related peripheral neuropathy.
Findings show that Cep72 is the key protein essential for maintaining microtubule-organizing activity and structural integrity of the centrosome.
The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.
centrosomal protein 72kDa
, centrosomal protein 72 kDa
, centrosomal protein 72-like
, centrosomal protein of 72 kDa-like
, centrosomal protein of 72 kDa