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Chicken Monoclonal HSP90 Primary Antibody for AA, ELISA - ABIN361717
Loo, Jensen, Cui, Hou, Chang, Riordan: Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome. in The EMBO journal 1999
Show all 20 Pubmed References
Chicken Monoclonal HSP90 Primary Antibody for IF, IP - ABIN967958
Brouet, Sonveaux, Dessy, Balligand, Feron: Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. in The Journal of biological chemistry 2001
Show all 6 Pubmed References
Chicken Monoclonal HSP90 Primary Antibody for IF, IP - ABIN967957
Miyamoto, Nakayama, Imaki, Hirose, Jiang, Abe, Tsukiyama, Nagahama, Ohno, Hatakeyama, Nakayama: Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. in Nature 2002
Show all 6 Pubmed References
Human Monoclonal HSP90 Primary Antibody for WB - ABIN1882255
Yamazaki, Akaogi, Miwa, Imai, Soeda, Yokoyama: Nucleotide sequence of a full-length cDNA for 90 kDa heat-shock protein from human peripheral blood lymphocytes. in Nucleic acids research 1989
Show all 5 Pubmed References
Human Polyclonal HSP90 Primary Antibody for ICC, IF - ABIN361823
Arlander, Eapen, Vroman, McDonald, Toft, Karnitz: Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. in The Journal of biological chemistry 2003
Show all 10 Pubmed References
Human Monoclonal HSP90 Primary Antibody for ICC, IF - ABIN361731
Dalman, Bresnick, Patel, Perdew, Watson, Pratt: Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitro. in The Journal of biological chemistry 1989
Show all 12 Pubmed References
Fish Polyclonal HSP90 Primary Antibody for WB - ABIN361873
Barent, Nair, Carr, Ruan, Rimerman, Fulton, Zhang, Smith: Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes. in Molecular endocrinology (Baltimore, Md.) 1998
Show all 13 Pubmed References
Cow (Bovine) Monoclonal HSP90 Primary Antibody for IF, IP - ABIN222933
Lange, Kistler, Jutzi, Bazhin, Klemke, Schadendorf, Eichmueller: Detergent fractionation with subsequent subtractive suppression hybridization as a tool for identifying genes coding for plasma membrane proteins. in Experimental dermatology 2009
Show all 2 Pubmed References
Human Polyclonal HSP90 Primary Antibody for BP, Neut - ABIN266753
Liu, Zhang, Shi, Quinn, Bradner, Beyer, Chen, Zhang: Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Show all 2 Pubmed References
Chicken Monoclonal HSP90 Primary Antibody for ICC, IF - ABIN266159
Fang, Inanc, Schamus, Wang, Wei, Brown, Svilar, Sugrue, Goellner, Zeng, Yates, Lan, Vens, Sobol: HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. in Nature communications 2014
Show all 2 Pubmed References
The findings establish an active role for Tsc1 (show TSC1 Antibodies) as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients-including Tsc2 (show TSC2 Antibodies)-thereby preventing their ubiquitination and proteasomal degradation.
Data indicate HSP90 inhibitors as a class of preferred drugs for treatment combination with immunotherapy.
Data suggest that SOCS3 (show SOCS3 Antibodies) is an important signaling protein in CLL, and Hsp90 inhibitors represent an approach to target transcriptional repression in B cell lymphoproliferative disorders.
We found that HSF1 (show HSF1 Antibodies) activation mediated by 1,4-NQ upregulated downstream genes, such as HSPA6 (show HSPA6 Antibodies). The results suggest that activation of the HSP90-HSF1 (show HSF1 Antibodies) signal transduction pathway mediated by 1,4-NQ protects cells against 1,4-NQ and that per/polysulfides can diminish the reactivity of 1,4-NQ by forming sulfur adducts.
FKBP51 (show FKBP4 Antibodies) is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (show FKBP4 Antibodies) (but not FKBP52 (show FKBP4 Antibodies)) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria.
High HSP90 expression is associated with Colorectal Cancers.
High HSP90 expression is associated with prostate cancer.
Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)
Data show that pyruvate kinase M2 (PKM2) directly interacted with mutant growth factor receptor (show RYK Antibodies) (EGFR (show EGFR Antibodies)) and heat-shock protein 90 (HSP90), and thus stabilized EGFR (show EGFR Antibodies) by maintaining its binding with HSP90 and co-chaperones.
Binding of FM807 to the N-terminus of Hsp90 disrupted Hsp90/client complexes, resulting in degradation of the Hsp90 client protein EGFR (show EGFR Antibodies) and inhibition of the downstream pathway.
DAF-21 Ienterd this protein as newentry study explores the role and contribution of MAP Kinase pathway and its regulator protein DAF-21 involvement in the immunity against opportunistic pathogen P. mirabilis infection
We demonstrate that while DAF-16/FOXO is dispensable, the age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone
We found that HLH-1-dependent myogenic conversion specifically induced the expression of putative HLH-1-regulated chaperones in differentiating muscle cells. Moreover, disrupting the putative HLH-1-binding sites on ubiquitously expressed daf-21(Hsp90) and muscle-enriched hsp-12.2(sHsp) promoters abolished their myogenic-dependent expressio
The activity of protein phosphatase 5 towards native clients, such as glucocorticoid receptor (show NR3C1 Antibodies), is modulated by the middle- and C-terminal domains of Hsp90.
Suppression of misfolding in muscle cells is achieved not only by enhanced expression of HSP90 in muscle cells but also by elevated expression of HSP90 (Daf-21) in intestine or neuronal cells. This cell-nonautonomous control of HSP90 expression relies upon transcriptional feedback between somatic tissues that is regulated by the FoxA transcription factor PHA-4.
Hsp90 (DAF-21) appears to participate in the maintenance of muscle structures as a transiently associated diffusible factor
DAF-21 indirectly regulates the meiotic prophase/metaphase transition during oocyte development by ensuring the normal function of WEE (show WEE1 Antibodies)-1.3.
PA28 is likely to function in collaboration with Hsp90.
Escargot and Scratch regulate neural commitment by antagonizing Notch (show NOTCH1 Antibodies) activity in Drosophila sensory organs
Nup358 (show RANBP2 Antibodies) facilitates JH-induced Met nuclear transport in a manner dependent on importin beta (show KPNB1 Antibodies) and Hsp83.
We show that while Hsp70 or Hsp83 expression under normal or stress conditions was not affected by AR feeding, Hsp27 levels were elevated in AR-fed wild-type control as well as heat-shocked larvae
The results revealed that the high-fat diet augmented the rate of lipid peroxidation and SOD (show SOD2 Antibodies) and CAT activity and induced a higher expression of HSP83 and MPK2 (show MAPK1 Antibodies) mRNA.
Hsp83 facilitates methoprene-tolerant nuclear import to modulate juvenile hormone signaling.
Interaction of Spag with both Hsp70 and Hsp90 suggests a model whereby R2TP would accompany clients from Hsp70 to Hsp90 to facilitate their assembly into macromolecular complexes.
Our results reveal that Hsp83 plays a heretofore unappreciated role in promoting APC (show APC Antibodies)/C function during cell cycle exit and suggest a mechanism by which Hsp90 inhibition could promote genomic instability and carcinogenesis
Using computational and biochemical analyses, study find that Hsp90 maintains and optimizes RNA polymerase II pausing via stabilization of the negative elongation factor (show RDBP Antibodies) complex.
Data suggest that that an Sgt1 (show SUGT1 Antibodies)/Hsp90-LKB1 (show STK11 Antibodies)-AMPK (show GRK4 Antibodies) pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.
Piwi (show PIWIL1 Antibodies) functions in Hsp90-mediated suppression of phenotypic variation
Fusion of human SGT1 (show SUGT1 Antibodies) (hSGT1 (show ECD Antibodies)) to NOD1 (show NOD1 Antibodies) LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha (show HSP90AA2 Antibodies).
The major capsid protein of the mouse polyomavirus VP1 binds microtubules, HSP90, promotes their acetylation and blocks the host cell cycle.
Artificially maintaining Hsp90alpha (show HSP90AA2 Antibodies) or knocking down Aarsd1L expression interferes with the differentiation of C2C12 myotubes.
Immune-mediated destruction of ovarian follicles associated with the presence of HSP90 antibodies.
identify that Hsp90alpha (show HSP90AA2 Antibodies) at the transition neck region represents a signalling platform on which IRS-1 (show IRS1 Antibodies) interacts with intracellular downstream signalling molecules involved in IGF-1 (show IGF1 Antibodies) receptor signalling.
The study demonstrated that HSP90alpha plays an important role in the biogenesis of fetal PIWI-interacting RNAs (piRNA), which act against the transposon activities, in mouse male germ cells.
Data show that the heat shock protein 90 (HSP90) isoforms HSP90AA1 (show HSP90AA1 Antibodies) and HSP90AB1 (show HSP90AB1 Antibodies) are responsible for maintaining proper cellular levels of BMAL1 (show ARNTL Antibodies) protein.
deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation
study identified the essential role of Hsp90 in iNOS (show NOS2 Antibodies) gene transactivation
Hsp90alpha (show HSP90AA2 Antibodies) may be required to maintain and to activate these regulators and/or to disassemble the synaptonemal complex that holds homologous chromosomes together
This study firstly found that host chaperone heat shock protein 90 (Hsp90) had a positive regulatory effect on the porcine circovirus type 2 infection cycle in vitro.
Feed intake remains low whereas respiratory frequency and body temperature remain higher and expression of HSP90, CAT1 (show SLC7A1 Antibodies), SGLT1 (show SLC5A1 Antibodies) and GLUT4 (show SLC2A4 Antibodies) increases in some tissues in pigs under chronic heat stress conditions.
HSP90AA1 (show HSP90AA1 Antibodies) sperm content and the prediction of the boar ejaculate freezability.
Hsp90 is a modulator of eNOS (show NOS3 Antibodies) activity and vascular reactivity in the newborn piglet pulmonary circulation
Apo (show C9orf3 Antibodies)-Hsp90 is in a conformational equilibrium between two open states that have never been described previously.
Findings indicate an essential role for Hsp90 in nongenomic estrogen signaling in coronary artery smooth muscle cells.
Mapped six genes (EIF4G3 (show EIF4G3 Antibodies), HSP90 (show HSP90AB1 Antibodies), RBBP6 (show RBBP6 Antibodies), IL8 (show IL8 Antibodies), TERT (show TERT Antibodies), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
Hsp90 (show HSP90AB1 Antibodies) is involved in opposing signaling pathways of cartilage homeostasis and catabolic responses are more sensitive to Hsp90 (show HSP90AB1 Antibodies) inhibition than are anabolic responses.
Data from Xenopus laevis embryo suggest hsp90alpha (show HSP90AA2 Antibodies) and hsp90Beta (show HSP90AB1 Antibodies) genes are conserved among vertebrates, and are differentially regulated in a tissue, stress, and development stage-specific manner. Hspalpha may play a role in myogenesis.
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.
, epididymis luminal secretory protein 52
, heat shock 86 kDa
, heat shock 90kD protein 1, alpha
, heat shock 90kD protein 1, alpha-like 4
, heat shock 90kD protein, alpha-like 4
, heat shock 90kDa protein 1, alpha
, heat shock protein HSP 90-alpha
, renal carcinoma antigen NY-REN-38
, heat shock protein Hsp90
, heat shock protein 90
, Heat Shock Protein 90
, heat shock protein 83
, enhancer of sevenless 3A
, enhancer of seven in absentia 2
, heat shock protein 1, alpha
, heat shock protein 86
, heat shock protein 90kDa alpha (cytosolic), class A member 1
, heat shock protein, 1
, heat shock protein, 86 kDa 1
, heat shock protein, 89 kDa
, tumor-specific transplantation 86 kDa antigen
, 90-kDa heat shock protein
, Heat shock protein HSP 90-beta-like protein
, heat shock protein HSP 90-beta
, hsp90 alpha
, heat shock protein-90