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KLHL21 localizes to midzone microtubules in anaphase & recruits aurora B (show AURKB Proteins) & Cul3 (show CUL3 Proteins) to this region; results suggest that different Cul3 (show CUL3 Proteins) adaptors nonredundantly regulate aurora B (show AURKB Proteins) during mitosis, possibly by ubiquitinating different pools of aurora B (show AURKB Proteins)
Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
kelch-like protein 21
, kelch-like 21 (Drosophila)
, kelch-like 21