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KNSTRN Mutation, a Cutaneous Squamous Carcinoma-Specific Mutation is associated with Solid Tumors and Leukemias.
Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin (show SPAG5 Proteins) have been reported.
study reports presence of KNSTRN mutations in basal cell carcinomas (BCC); mutant KNSTRN disrupts sister chromatid cohesion and promotes genomic instability in functional assays; KNSTRN mutations in BCC appear to occur late in disease progression and are preferentially found in advanced tumors
Mechanistically, the N-terminal of SKAP binds to EB1, and its C terminus binds to IQGAP1 in migrating cells.
These findings suggest that SKAP promotes ultraviolet rays-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19.
Findings suggest a role for kinetochore protein KNSTRN mutagenesis in cutaneous squamous cell carcinomas (SCCs) development.
SKAP constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division.
SKAP cooperates with CENP-E (show CENPE Proteins) to orchestrate dynamic kinetochore-microtubule interaction for faithful chromosome segregation.
This paper identifies role of gene product of FLJ14502, named SKAP in the paper, in mitosis. SKAP promotes metaphase-to-anaphase transition by mediating seperase activation after spindle assembly checkpoint is satisfied in mitosis.
Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (By similarity).
TRAF4 associated factor 1 homolog
, TRAF4-associated factor 1
, kinetochore-localized astrin-binding protein
, kinetochore-localized astrin/SPAG5-binding protein
, putative TRAF4-associated factor 1
, small kinetochore-associated protein
, TRAF4 associated factor 1
, small kinetochore associated protein
, small kinetochore-associated protein, kinetochore-localized astrin-binding protein, TRAF4 associated factor 1