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Human XPO1 ELISA Kit for Sandwich ELISA - ABIN417973
Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Nuclear export of TIS11 (show ZFP36 ELISA Kits) proteins is mediated by CRM1 through diverging nuclear export signals, while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 (show ZNF2 ELISA Kits) folding.
HPO (show GFER ELISA Kits) promotes the translocation of SD to the cytoplasm in a CRM1-dependent manner
Exportin-1 is a nuclear export receptor for expanded polyQ containing proteins.
Nuclear localization of the ecdysteroid receptor (EcR) is increased in HeLa cells if exportin-1 (CRM1) is knocked down by siRNA against exportin.
Data show that downregulation of YAN involves CRM1-mediated nuclear export, and that MAE is involved in MAPK (show MAPK1 ELISA Kits) phosphorylationof YAN.
A major function of DNup88 is to anchor DNup214 (show NUP214 ELISA Kits) and CRM1 on the nuclear envelope and thereby attenuate NES (show NES ELISA Kits)-mediated nuclear export.
Phosphorylation of Yan favors Crm1 in this competition and counteracts inhibition of nuclear export by Mae
two functional nuclear export signals are in the Sima basic helix-loop-helix (bHLH) domain and promote CRM1-dependent nuclear export
XPO1 inhibition selectively targets KRAS-mutant NSCLC cells by suppressing NFkappaB signaling.Targeting XPO1 promotes accumulation of IkBa to inhibit NFkappaB signaling and reduce cell survival.XPO1 inhibitors may be beneficial in treating patients with KRAS-mutant non-small cell lung cancer
Here, the authors identify cellular nuclear transport factor 2 (NTF2 (show NUTF2 ELISA Kits))-like export protein 1 (NXT1 (show NXT1 ELISA Kits)) as a novel binding partner of nucleoprotein (NP) that stimulates NP-mediated nuclear export via the CRM1-dependent pathway.
Data show that the cytoplasmic localization of promyelocytic leukaemia (PML (show PML ELISA Kits)) is mediated by its nuclear export in a chromosomal maintenance 1 (CRM1)-dependent manner.
CRM1 and CDK5 (show CDK5 ELISA Kits) co-expression was an independent prognostic factors for gastric cancer (GC). Combined CRM1 and CDK5 (show CDK5 ELISA Kits) expression could provide a prognostic model for overall survival of GC.
Anti-tumor activity of selective exportin 1 inhibitors is enhanced in non-Hodgkin lymphoma through combination with mTOR (show FRAP1 ELISA Kits) inhibitor and dexamethasone.
the functional consequences of a recurrent cancer-related mutation, which targets a residue near CRM1 NES (show NES ELISA Kits)-binding cleft, was investigated.
we characterized the biologic significance of CRM1 in the context of Ewing sarcoma and determined the therapeutic merit of CRM1 inhibition for this malignancy.
XPO1 E571K mutation represents a genetic hallmark of the PMBL subtype and serves as a new relevant PMBL biomarker. SINE compounds appear active for both mutated and wild-type protein
CRM1 mediates nuclear export of influenza A nucleoprotein.
the detection of the XPO1 E571K mutation in biopsy and plasma cell-free DNA by digital PCR may be used as a novel biomarker in classical Hodgkin lymphoma for both diagnosis and minimal residual disease, and pinpoints a crucial role of XPO1 in classical Hodgkin lymphoma pathogenesis.
CRM1 binds to Axin (show AXIN1 ELISA Kits) in the presence of RanGTP
Data show that administration of a single dose of selinexor bound Exportin 1 (XPO1/CRM1) for minimally 72 hours both in vitro and in vivo.
These results suggest a model wherein HIV-1 Rev-associated nuclear export signals cooperate to regulate the number or quality of CRM1's interactions with viral Rev/RRE ribonucleoprotein (show RBP31 ELISA Kits) complexes in the nucleus.
map the nuclear import and export signals of Dp71d by truncation and point mutant analysis, showing for the first time Dp71d shuttles between nucleus and cytoplasm mediated by conventional nuclear transporters, importin (IMP (show BRAP ELISA Kits)) alpha/beta and the exportin CRM1
AKT3 (show AKT3 ELISA Kits) controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.
A CRM1-mediated nuclear export signal is essential for cytoplasmic localization of neurogenin 3 (show NEUROG3 ELISA Kits) in neurons.
Bioavailable CRM1 inhibitor KPT-251 significantly inhibited renal cell carcinoma growth in vivo with the expected on target effects and no obvious toxicity.
CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells
CaMKI (show CAMK1 ELISA Kits) vies with CRM1/exportin 1 for access to a nuclear export signal, and assembly of a CaMKI (show CAMK1 ELISA Kits)-14-3-3 zeta (show YWHAZ ELISA Kits)-CCTalpha (show PCYT1A ELISA Kits) complex is a key effector mechanism that drives nuclear CCTalpha (show PCYT1A ELISA Kits) translocation.
Transcription-independent role of Bach1 (show BACH1 ELISA Kits) in mitosis through a nuclear exporter Crm1-dependent mechanism.
CRM1 protein-mediated regulation of nuclear clusterin (show CLU ELISA Kits) (nCLU), an ionizing radiation-stimulated, Bax (show BAX ELISA Kits)-dependent pro-death factor
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
, chromosomal region maintenance 1
, exportin 1
, exportin 1 (CRM1 homolog, yeast)
, exportin 1-like
, CRM1, yeast, homolog
, chromosome region maintenance 1 protein homolog
, exportin 1 (CRM1, yeast, homolog)
, exportin-1 (required for chromosome region maintenance)
, nuclear export factor CRM1
, CRM1/XPO1 protein