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Human Monoclonal FAF1 Primary Antibody for IF, WB - ABIN393433
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN393433
Human Polyclonal FAF1 Primary Antibody for EIA, IHC (p) - ABIN499818
Ryu, Kim: Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain. in Biochemical and biophysical research communications 2001
Show all 5 references for ABIN499818
Human Polyclonal FAF1 Primary Antibody for IP, IHC - ABIN223070
Altomare, Menges, Pei, Zhang, Skele-Stump, Carbone, Kane, Testa: Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. in Proceedings of the National Academy of Sciences of the United States of America 2009
Human Polyclonal FAF1 Primary Antibody for ELISA, WB - ABIN564825
Baron, Pedrioli, Tyagi, Johnson, Wood, Fountaine, Wightman, Alexandru: VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. in BMC biology 2014
This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Antibodies), FAF1 and PTH1R (show PTH1R Antibodies) with some of leg weakness related traits in pigs.
FAF1 plays a novel role in negatively regulating virus-induced IFN-beta (show IFNB1 Antibodies) production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 (show IRF3 Antibodies) from the cytosol to the nucleus
Progression of the DNA replication fork is coordinated by FAF1. FAF1 binds to the licensing factor CDT-1 (show CDT1 Antibodies) and additional ubiquitylated proteins, thus promoting CDC48 (show vcp Antibodies)-dependent turnover and disassembly of DNA replication factor (show CDT1 Antibodies) complexes.
Report a novel role for FAF1 in regulating CD40-induced NFkappaB activation via a negative feedback loop.
The repertoire of VAPB (show VAPB Antibodies) interactors is more diverse than previously anticipated and link VAPB (show VAPB Antibodies) to the function of ATPase (show DNAH8 Antibodies) complexes such as p97 (show EIF4G2 Antibodies)/FAF1 and ASNA1 (show ASNA1 Antibodies)/transmembrane-domain recognition complex.
long-chain unsaturated fatty acids also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8 (show FAF2 Antibodies)
Data indicate that Npl4-Ufd1 (show UFD1L Antibodies) heterodimer is required for VCP (show vcp Antibodies)-FAF1 interaction.
hFAF1 inhibits tumor formation by increasing the degradation of Hsp70 (show HSP70 Antibodies) mediated via its UBA domain.
Fas-associated factor 1 is a scaffold protein (show HOMER1 Antibodies) that promotes beta-transducin repeat-containing protein (beta-TrCP (show BTRC Antibodies))-mediated beta-catenin (show CTNNB1 Antibodies) ubiquitination and degradation.
Wild-type p97/VCP (show vcp Antibodies) ND1 (show MT-ND1 Antibodies) in complex with FAF1 UBX crystallized into very thin sheet-shaped crystals which turned out to be of poor diffraction quality
The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 (show NLRP12 Antibodies) pyrin (show MEFV Antibodies) domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links the innate immune system to apoptotic signaling.
Increased FAF1 expression triggers caspase-3 (show CASP3 Antibodies) cleavage and activation, leading to hyperphosphorylated tau aggregation and subsequent neurofibrillary tangles formation, in turn initiating apoptosis.
Taken together, these results suggest a new role for FAF1: that of a positive modulator for Parkinson's disease .
FAF1 is a novel inhibitory factor of canonical Wnt (show WNT2 Antibodies) signaling pathway
Capsaicin-induced cancer cell apoptosis involves FAF1, a TRPV1 (show TRPV1 Antibodies) associated protein.
Analysis of FAF1 expression revealed that the protein is present in early preimplantation stages, while embryonic expression of Faf1 mRNA becomes appreciable at 4-cell stage.
Data show that Faf1 protein level is down-regulated during apoptosis in a caspase-3 (show CASP3 Antibodies)- and Apaf1 (show APAF1 Antibodies)-dependent manner.
analysis of the negative feedback regulation of Aurora-A (show AURKA Antibodies) via phosphorylation of Fas-associated factor-1
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.
Fas (TNFRSF6) associated factor 1
, FAS-associated factor 1
, FAS-associated factor 1-like
, TNFRSF6-associated factor 1
, UBX domain protein 3A
, UBX domain-containing protein 12
, UBX domain-containing protein 3A