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Mouse (Murine) KEAP1 ELISA Kit for Sandwich ELISA - ABIN1980574
Kabel, Abd Elmaaboud, Atef, Baali: Ameliorative potential of linagliptin and/or calcipotriol on bleomycin-induced lung fibrosis: In vivo and in vitro study. in Environmental toxicology and pharmacology 2017
Result showed that there was a significant association between Keap1 and phosphorylated (p) Nrf2 (show GABPA ELISA Kits) expression in hepatocellular carcinoma. Higher pNrf2 expression was more likely observed in those specimens with reduced Keap1 expression.
Results provide evidence for a critical role of mutations in TP53 (show TP53 ELISA Kits) and KEAP1 during lung squamous cell carcinoma (LSCC oncogenesis, because deletion of either gene leads to increased self-renewal of airway basal stem cells. Also, KEAP1/NRF2 (show GABPA ELISA Kits) mutations increase radioresistance and predict local tumor recurrence in radiotherapy treated LSCC patients.
Study showed that Sequestosome 1 (show SQSTM1 ELISA Kits)-mediated sequestration of Keap1 is associated with chronic activation of the Nrf2 (show GABPA ELISA Kits) stress response pathway in the autophagic vacuolar myopathie muscle; demonstrated that Nrf2 (show GABPA ELISA Kits) signaling is upregulated in autophagic muscle disorders and raise the possibility that autophagy disruption in skeletal muscle leads to dysregulation of cellular redox homeostasis.
Keap1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of Cullin 3 (show CUL3 ELISA Kits)-based E3 ubiquitin ligase. Keap1 regulates the activity of Nrf2 (show GABPA ELISA Kits) and acts as a sensor for oxidative and electrophilic stresses.
NRF2 (show GABPA ELISA Kits) is regulated at protein level by proteasomal degradation via KEAP1. Data suggest that antioxidant-induced up-regulation of NRF2 (show GABPA ELISA Kits) expression (a) overcomes KEAP1 regulation, (b) activates NRF2 (show GABPA ELISA Kits) translocation to nucleus, and (c) activates antioxidant response element. (NRF2 (show GABPA ELISA Kits) = nuclear factor [erythroid-derived 2]-like 2 protein; KEAP1 = Kelch-like ECH-associated protein 1)
Results indicate that microRNA miR (show MLXIP ELISA Kits)-141 targets kelch like ECH associated protein 1 (Keap1) to activate NF-E2-related factor 2 (Nrf2 (show NFE2L2 ELISA Kits)) signaling, which protects retinal pigment epithelium cells (RPEs) and retinal ganglion cells (RGCs) from UV radiation.
The authors show that O-GlcNAcylation of KEAP1 by OGT (show OGT ELISA Kits) at serine 104 is required for the efficient ubiquitination and degradation of NRF2 (show GABPA ELISA Kits).
Data indicate the role of kelch like ECH associated protein 1 (Keap1)/nuclear factor E2-related factor 2 (Nrf2 (show GABPA ELISA Kits)) axis deregulation with potential new function as independent epigenetic prognostic marker in renal cell carcinoma.
clinical cholangiocarcinoma samples displayed FoxO3 (show FOXO3 ELISA Kits)-Keap1 down-regulation and Nrf2 (show GABPA ELISA Kits) hyperactivation
the dual role of nuclear factor-erythroid 2 signaling in induction of colorectal cancer cell survival and death as well as the possibility of targeting nuclear factor-erythroid 2-kelch-like ECH-associated protein 1 axis as an advanced strategy in prevention and effective treatment of colorectal cancer patients have been discussed.
the potency of 15d-PGJ2 as a signalling molecule (show GDF5 ELISA Kits) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
Keap1 deletion in renal tubular cells results in an abnormal kidney development consistent with hydronephrosis.
serine 351 phosphorylation of p62 (show GTF2H1 ELISA Kits) did not enhance its binding to Keap1 or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (show NFE2L2 ELISA Kits)) transcription factor in this neuronal context. Nrf2 (show NFE2L2 ELISA Kits) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (show NFE2L2 ELISA Kits) gene
These results suggest that the Keap1/Nrf2 (show NFE2L2 ELISA Kits) axis plays a critical role in NFATc1 (show NFATC1 ELISA Kits) expression and osteoclastogenic progression.
Results show that Keap1 deficiency in long-term hematopoietic stem cells increases the number of multipotent progenitor cells in steady-state hematopoiesis, and impairs their hematopoietic regeneration capacity .
During cellular stress or electrolytic imbalance, cysteine residue modification in Keap1 induces Nrf2 (show NFE2L2 ELISA Kits) release from the Nrf2 (show NFE2L2 ELISA Kits)-Keap1 complex, which stabilizes Nrf2 (show NFE2L2 ELISA Kits) and causes its nuclear translocation.
Results showed that in the basal state, the amount of Keap1 and Cul3 (show CUL3 ELISA Kits) proteins were maintained at higher levels than that of Nrf2 (show NFE2L2 ELISA Kits), and remained the same even under oxidative and electrophilic stimuli.
This study found that under oxidative stress induced (show SQSTM1 ELISA Kits) by experimental periodontitis, the Nrf2 (show NFE2L2 ELISA Kits)/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the in Keap1-dependent oxidative stress detector-luciferase mice model.
Caffeic acid induces Nrf2 (show NFE2L2 ELISA Kits) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 ELISA Kits) with Keap1.
Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 ELISA Kits) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN ELISA Kits) independently of its role in oxidant stress responses.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 ELISA Kits), indicating that the presence of either Cys (show DNAJC5 ELISA Kits)-273 or Cys (show DNAJC5 ELISA Kits)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 ELISA Kits) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 ELISA Kits)-151 and Cys (show DNAJC5 ELISA Kits)-273, for a variety of Nrf2 (show NFE2L2 ELISA Kits)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein