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Cheung, Sun, Kanwar, Bai, Cheng, Krissansen: Correction: A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy. in Cancer cell international 2010
Show all 22 Pubmed References
Patil, Kim, Jayaprakasha: Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway. in European journal of pharmacology 2010
Show all 38 Pubmed References
Zhang, Chen, De Paiva, Corrales, Volpe, McClellan, Farley, Li, Pflugfelder: Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. in Investigative ophthalmology & visual science 2011
Show all 13 Pubmed References
Abdel-Latif, Murray, Renberg, ONeill, Porter, Jensen, Johnson: Cell death in bovine parvovirus-infected embryonic bovine tracheal cells is mediated by necrosis rather than apoptosis. in The Journal of general virology 2006
Show all 6 Pubmed References
Human Caspase 9 ELISA Kit for Sandwich ELISA - ABIN414425
Chen, Huang, Huang, Liu, Lin, Liu, Hsieh, Shiu, Chen: Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. in BMC cancer 2016
Show all 2 Pubmed References
Rat (Rattus) Caspase 9 ELISA Kit for Sandwich ELISA - ABIN416113
Abdelkader, Safar, Salem: Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson's Disease: Modulation of Mitochondrial Perturbations. in Molecular neurobiology 2015
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Wallach-Dayan, Izbicki, Cohen, Gerstl-Golan, Fine, Breuer: Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. in American journal of physiology. Lung cellular and molecular physiology 2006
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Mouse (Murine) Caspase 9 ELISA Kit for Sandwich ELISA - ABIN415448
Zobeiri, Salami, Sadrkhanlou, Peirouvi: Role of mitochondria in ciprofloxacin-induced apoptosis in murine sperm cells. in Reproductive sciences (Thousand Oaks, Calif.) 2013
Mouse (Murine) Caspase 9 ELISA Kit - ABIN365510
Li, He, Zhou, Jiang, Cheng: The antitumor activity of PNA modified vinblastine cationic liposomes on Lewis lung tumor cells: In vitro and in vivo evaluation. in International journal of pharmaceutics 2015
Human Caspase 9 ELISA Kit for Sandwich ELISA - ABIN811993
Li, Zhou, Jiang, He, Jia, Zhao, Cheng, Jia: PEGylated VRB plus quinacrine cationic liposomes for treating non-small cell lung cancer. in Journal of drug targeting 2014
inducible caspase-9 (iC9) safety switch can eliminate CD19 (show CD19 ELISA Kits).CAR-Ts in a dose-dependent manner, allowing either a selective containment of CD19 (show CD19 ELISA Kits).CAR-T expansion in case of CRS (show CARS ELISA Kits) or complete deletion on demand granting normal B cell reconstitution.
Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 and caspase-3 (show CASP3 ELISA Kits)/7, in a dose-dependent fashion.
Bcl-2 (show BCL2 ELISA Kits)-caspase-9 apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related proteins.
Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.
The study demonstrates sublethal caspase (show CASP3 ELISA Kits)-activation has an important role in cardiomyocyte differentiation and may have significant implications for promoting cardiac regeneration after myocardial injury involving exogenous or endogenous cell sources.
Casp6 (show CASP6 ELISA Kits) knockout in YAC128 mice does not abolish the presence of the mutant HTT (show HTT ELISA Kits) protein-586 fragment but ameliorates depression, body weight gain, IGF-1 (show IGF1 ELISA Kits) and BDNF (show BDNF ELISA Kits) levels in YAC128 mice.
study demonstrates that MMP-3 (show MMP3 ELISA Kits) leads to caspase-9 activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1 (show APAF1 ELISA Kits)
caspase-9 mediates Puma (show BBC3 ELISA Kits) activation to determine the threshold for overcoming chemoresistance in cancer cells.
Casp9, the initiator caspase (show CASP3 ELISA Kits) of the intrinsic apoptotic cascade, has a role in murine fetal and adult hematopoiesis
findings demonstrate that focal activation of caspase-9 and -3 at neuromuscular junctions is essentially responsible for subsynaptic DNA damage and apoptotic synaptic degeneration in slow-channel myasthenic syndrome
Fisetin inhibited Triple-Negative Breast Cancer Cells cell division and induced apoptosis, which was associated with mitochondrial membrane permeabilization and the activation of caspase-9 and caspase-8 (show CASP8 ELISA Kits), as well as the cleavage of poly(ADP-ribose) polymerase-1 (show PARP1 ELISA Kits).
High CASP9 expression is associated with Lung Tumorigenesis.
caspase-8 (show CASP8 ELISA Kits) and caspase-9 contribute to the cyclic stretch-induced apoptosis, but functioned differently at different stages in human periodontal ligament cells
knockdown of HMGI-C led to the significant induction of apoptosis via mitochondrial pathway by inducing miR34a and cell cycle arrest in MDA-MB-468 cells in vitro.
Results suggest that the formation of the apoptosome accompanied by the activation of caspase-9 may occur in brains affected by multiple system atrophy (MSA (show TPO ELISA Kits)), and that a mitochondria-dependent apoptotic pathway may be partially associated with the pathogenesis of MSA (show TPO ELISA Kits).
Using recombinant proteins, this study investigated the influence of survivin (show BIRC5 ELISA Kits) on the inhibition of caspase-9 by XIAP (show XIAP ELISA Kits) in vitro. With a fluorescence-based assay for the apoptosome-stimulated activity of caspase-9, the study shows that survivin (show BIRC5 ELISA Kits) has no effect on the inhibition of caspase-9 by XIAP (show XIAP ELISA Kits), neither in the presence nor in the absence of Smac (show DIABLO ELISA Kits).
LRRC8A (show LRRC8A ELISA Kits) is an essential regulator of cisplatin induced p53 (show TP53 ELISA Kits) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2 (show MDM2 ELISA Kits), as well as activation of caspase-9 and -3 in tumor cell lines.
Data show that caspase 9 (CASP9) single nucleotide polymorphism (rs1052576) TT genotype was seemed to be associated with higher risk of pathological stage.
Data show that the apoptotic and cytotoxic effects of BL-038 are mediated by the intrinsic mitochondria-mediated apoptotic pathway, which in turn causes the activation of caspase-9 and caspase-3 (show CASP3 ELISA Kits), and the cleavage of poly (ADP-ribose) polymerase (PARP (show PARP1 ELISA Kits)), to elicit apoptosis response.
Downregulation of DNMT3a (show DNMT3A ELISA Kits) regulated miR (show MLXIP ELISA Kits)-182 via caspase-3 (show CASP3 ELISA Kits) and -9-mediated apoptosis and DNA damage response in ovarian cancer.
Suppression of caspase-9 resulted in significant upregulation of cell proliferation-, adhesion-, growth-, development- and division-regulating genes, and the downregulation of cell death program- and stress response-regulating genes.
Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 (show CASP8 ELISA Kits) and caspase-9.
The ATP and cytochrome c (show CYCS ELISA Kits) dependent activation of caspase-9 is increased during hypoxia. The ATP and cytochrome c (show CYCS ELISA Kits) sites of Apaf-1 (show APAF1 ELISA Kits) that mediate caspase-9 activation are modified during hypoxia.
Results suggest that zearalenone induces apoptosis and necrosis of porcine granulosa cells in a dose-dependent manner via a caspase-3 (show CASP3 ELISA Kits)- and caspase-9-dependent mitochondrial pathway.
We conclude that the hypoxia-induced activation of caspase-9 is mediated by Src kinase (show CSK ELISA Kits).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1\; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
, ICE-like apoptotic protease 6
, apoptotic protease Mch-6
, apoptotic protease-activating factor 3
, 25 kDa caspase-9 dominant negative protein
, Ice-like apoptotic protease 6
, apoptotic protease activating factor 3
, caspase-9 dominant negative form
, caspase-9-carboxyl-terminal divergent
, apoptotic protease MCH-6
, protein phosphatase 1, regulatory subunit 56
, caspase 9, apoptosis-related cysteine protease