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AMPK (show PRKAA1 ELISA Kits) phosphorylation of cortactin followed by SIRT1 (show SIRT1 ELISA Kits) deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 ELISA Kits)/SIRT1 (show SIRT1 ELISA Kits) coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 ELISA Kits) subcellular translocation/activation and is atheroprotective.
Cortactin may have an important role in the development of oral tumors in mice
findings reveal that Keap1 (show KEAP1 ELISA Kits) regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses.
association of cortactin with Pfn-1 (show PFN1 ELISA Kits) is regulated by c-Abl (show ABL1 ELISA Kits)-mediated cortactin phosphorylation
Cell proliferation, migration and invasion were inhibited by genetic knockdown of EMS1.
our findings suggest that after GnRHa activation, src activity leads to tyrosine phosphorylation of cortactin, which facilitates its association with Arp3 to engage the actin cytoskeleton.
GIT1-cortactin association through GIT1-Spa (show FASL ELISA Kits) homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis.
Data indicate that cortactin as an Src (show SRC ELISA Kits)-dependent interacting partner of EB1 (show MAPRE1 ELISA Kits).
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin binding of HPK1 peptide.
mXinalpha together with cortactin is able to modulate the p120-catenin (show CTNND1 ELISA Kits) activity for shape change and adhesion at the intercalated discs.
These findings suggest that this common cortactin variant may functionally contribute to ALI predisposition by impeding endothelial wound healing.
cortactin binds to E-cadherin (show CDH1 ELISA Kits), and that a posttranslational modification of cortactin, RhoA (show RHOA ELISA Kits)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (show PRKD1 ELISA Kits)) at S298, impairs adherens junction assembly and supports their dissolution.
Unique role for PBF (show PTTG1IP ELISA Kits) in regulating CTTN function to promote endocrine cell invasion and migration.
These data suggest a model in which cortactin promotes exosome secretion by stabilizing cortical actin-rich multivesicular late endosome docking sites.
Cortactin may have an important role in the development of oral tumors in human
a dynamic TIP150-cortactin interaction orchestrates directional cell migration via coupling dynamic microtubule plus ends to the cortical cytoskeleton.
Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.
Amplification of 11q13 resulting in overexpression of CTTN/CCND1 (show CCND1 ELISA Kits) was the most prominent finding, which was observed in 13 of 19 ESCC cases.
The cortactin Tyr421 residue is required to promote cell proliferation both in vitro and in vivo.
the expression of CTTN, Exo70 (show EXOC7 ELISA Kits) and MMP-9 (show MMP9 ELISA Kits) in HCC (show FAM126A ELISA Kits) cells was detected and their relations with the ability of migration and invasion of hepatoma carcinoma cells were evaluated
our data suggest that cortactin and Arp2/3 mediated actin polymerization is implicated in the cell movement during gastrulation and perhaps the development of the central neural system as well.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
, src substrate cortactin
, Src substrate cortactin
, src substrate cortactin-like
, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
, src substrate protein p85
, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
, oncogene EMS1
, cortactin isoform B