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anti-Human HSPB1 Antibodies:
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Human Polyclonal HSPB1 Primary Antibody for IHC - ABIN966312
Scrimin, Axia, Tremolada, Pillon, Capello, Zanesco: Conversational strategies with parents of newly diagnosed leukaemic children: an analysis of 4880 conversational turns. in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2005
Show all 5 Pubmed References
Human Polyclonal HSPB1 Primary Antibody for IHC - ABIN966313
Jordan, Brownstone, Noga: Control of functional systems in the brainstem and spinal cord. in Current opinion in neurobiology 1993
Show all 3 Pubmed References
Human Polyclonal HSPB1 Primary Antibody for IF (p), IHC (p) - ABIN672441
Wang, Yang, Liu, Zhou, Wu, Qiao, Li, Wang: Dietary supplementation with the probiotic Lactobacillus fermentum I5007 and the antibiotic aureomycin differentially affects the small intestinal proteomes of weanling piglets. in The Journal of nutrition 2011
Show all 2 Pubmed References
Human Monoclonal HSPB1 Primary Antibody for FACS, IF - ABIN966308
Langer, Ott, Specht, Becker, Lordick, Burian, Herrmann, Schrattenholz, Cahill, Schwaiger, Hofler, Wester: Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
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Human Polyclonal HSPB1 Primary Antibody for IHC, WB - ABIN2779293
Lelj-Garolla, Mauk: Self-association and chaperone activity of Hsp27 are thermally activated. in The Journal of biological chemistry 2006
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Human Polyclonal HSPB1 Primary Antibody for ICC, IF - ABIN4319980
Stice, Chen, Kim, Jung, Tran, Liu, Knowlton: 17β-Estradiol, aging, inflammation, and the stress response in the female heart. in Endocrinology 2011
Show all 2 Pubmed References
Human Polyclonal HSPB1 Primary Antibody for IHC, IHC (p) - ABIN4319981
Azimi, Pernemalm, Frostvik Stolt, Hansson, Lehtiö, Egyházi Brage, Hertzman Johansson: Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance. in British journal of cancer 2014
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Human Polyclonal HSPB1 Primary Antibody for IHC, WB - ABIN1842443
Zhang, Pang, Loo, Rao, Go, Loo, Lu: Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells. in Proteomics 2011
Human Polyclonal HSPB1 Primary Antibody for IHC - ABIN966314
White, Hambly, Jeremy, Cordwell: Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium. in Journal of molecular and cellular cardiology 2006
Human Polyclonal HSPB1 Primary Antibody for IHC, WB - ABIN362748
Ma, Teng, Hua, Hou, Luo, Jiang: Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells. in The FEBS journal 2013
Loss of HspB1 specifically reduces myofibril size in embryonic craniofacial muscles.
Results show the sequence, expression, regulation, and function of a zebrafish protein (zfHsp27) and define zebrafish as a new model for the study of Hsp27 function.
initial upregulation of hsp27 expression occurs during early gastrulation
hspb1 is expressed during development
Hsp27 is dispensable for zebrafish morphogenesis but could play a role in long-term maintenance of heart and muscle tissues.
The data support a mechanism of Hsp27 function where interactions with the titin (show TTN Antibodies) filament system protect myofibrils from stress-induced degradation.
Xenopus HSP27, like HSP30, is a developmentally-regulated heat-inducible molecular chaperone (show HSP90AA1 Antibodies).
The up-regulation of Hsp27 by E2 is mediated by ERalpha (show ESR1 Antibodies)/Sp1 (show PSG1 Antibodies).
Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein (show PTBP1 Antibodies) PCBP1 (show PCBP1 Antibodies), leading to a reduction in its translational repression activity. Identifying PCBP1 (show PCBP1 Antibodies) mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases.
Hsp 70 (show HSP70 Antibodies) and Hsp 27 were expressed in middle ear effusions
Data suggest that hnRNPK plays role in heat shock response of cells by regulating HSF1; hnRNPK inhibits HSF1 activity, resulting in reduced expression of HSP27 and HSP70 mRNAs; hnRNPK also down-regulates binding of HSF1 to heat shock response element. (hnRNPK = heterogeneous-nuclear ribonucleoprotein K; HSF1 = heat shock transcription factor 1; HSP = heat-shock protein)
High Hsp27 expression is associated with Thyroid Tumors.
There is overwhelming evidence that molecular chaperones such as Hsp27, Hsp70 (show HSP70 Antibodies) and Hsp90 (show HSP90 Antibodies) are expressed at elevated levels in a wide range of cancers by stabilizing the mutated neoplasm proteins. (Review)
Bradykinin stimulates myofibroblast migration through protein kinase D (show PRKD1 Antibodies)-mediated activation of COX-2 (show COX2 Antibodies) and Hsp27.
Data suggest that HSPB6 forms hetero-oligomers with HSPB1 under the following rules: (1) highly conserved motif RLFDQXFG is necessary for subunit exchange among oligomers, (2) a site about 20 residues downstream of this motif determines size of resultant hetero-oligomers, and (3) a region in the N-terminal domain that is unique to HSPB6 dictates preferential formation of heterodimers. (HSP = heat shock protein)
TNF-alpha (show TNF Antibodies) stimulates colonic myofibroblast migration through P38 MAPK (show MAPK14 Antibodies)-mediated activation of COX-2 (show COX2 Antibodies) and Hsp27.
The potency of the sHsps to suppress aggregation of model substrates is correlated with their ability to form stable substrate complexes; especially HspB1 and HspB5 (show CRYAB Antibodies), but also B3, bind tightly to a variety of proteins
These findings suggest that HSPB1 mediates androgen signaling by binding directly to androgen receptor (show AR Antibodies) and then enhancing androgen-mediated myogenesis in myogenic cells.
HSPB1 could have an important role during testosterone-related myogenesis.
CaMKII (show CAMK2G Antibodies) is required for redox-sensitive activation of p38 MAPK (show MAPK14 Antibodies)/heat shock protein 27 pathway and ERK1/2 (show MAPK1/3 Antibodies)
It indicated that Hsp27 was required for porcine circovirus type 2 replication in PK-15 cells culture.
HSP27 expression is gut (show GUSB Antibodies) region- and cell type-specific in response to dietary components, microbes, and microbial metabolites to which the mucosa surface is exposed.
These results indicate that Hsp27 expression in the porcine gut (show GUSB Antibodies) could be associated with specific dietary fiber components but not the overall microbiota diversity.
Data suggest that targeting HSP27 might offer a useful strategy in cancer treatment.
Data show that the expression of HSP27 and CLIC1 (show CLIC1 Antibodies) was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively.
Data suggest that HSP27 enhanced the metastatic property of NPC (show NPC1 Antibodies) cells probably via the NF-kappaB (show NFKB1 Antibodies)-mediated activation of MMPs.
Hsp27 expression and its direct chaperoning interaction increase Akt (show AKT1 Antibodies) stability and p21 (show CDKN1A Antibodies) phosphorylation and nuclear-to-cytoplasm translocation, both essential effects for the survival of ultraviolet-induced DNA-damaged cells.
HSP27 could be a good candidate involved in migration and/or function of neutrophils within the porcine endmetrium.
HSP27 and HSP70 (show HSP70 Antibodies) may be used as differential markers to distinguish conventional and low grade central osteosarcoma.
HSP-27 and HSP-70 (show HSP70 Antibodies) contribute to modulation of K(+) channel (show KCNC4 Antibodies)-induced pial artery dilation
Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein PCBP1 (show PCBP1 Antibodies), leading to a reduction in its translational repression activity. Identifying PCBP1 (show PCBP1 Antibodies) mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases.
Expression of a phosphomimetic HSPB1 mutant in astrocytes reduced toxicity to motor neurons.
AMPK (show PRKAA1 Antibodies)-mediated HSPB1 expression enhanced insulin (show INS Antibodies) sensitivity in the skeletal muscle.
e confirmed the modulatory effect of Hspb1 on Purkinje cell degeneration (show AGTPBP1 Antibodies) in vivo, as knockdown by Hspb1 shRNA significantly enhanced neuron loss. These results suggest that strategies to promote HSPB1 activity may slow the rate of cerebellar degeneration in NPC (show NPC1 Antibodies) disease and highlight the use of bioinformatics tools to uncover pathways leading to neuronal protection in neurodegenerative disorders
Dp71Delta78-79 dystrophin (show DMD Antibodies) mutant stimulates neurite outgrowth in cultured neuronal cells via upregulation and phosphorylation of HspB1.
HSP27 expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 modulates lung fibroblast differentiation through the Smad3 (show SMAD3 Antibodies) and ERK (show EPHB2 Antibodies) pathways.
phosphorylated Hsp27 stimulates autophagy and lipid droplet clearance and interacts with STAT3 (show STAT3 Antibodies).
The phosphorylation of S82 of the heat shock protein 27 kDa (HSP27), was especially abundant and consistently upregulated in tissues with delays in freezing as short as 2 minutes.
HSPB1 depletion in a mouse model of lung tumorigenesis induced the endothelial-to-mesenchymal transition
HspB2 (show HSPB2 Antibodies) has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).
28 kDa heat shock protein
, HSP 27
, estrogen-regulated 24 kDa protein
, heat shock 27 kDa protein
, heat shock 27kD protein 1
, heat shock protein beta-1
, stress-responsive protein 27
, HSP 25
, growth-related 25 kDa protein
, heat shock 25 kDa protein
, heat shock 27kDa protein 1
, heat shock protein, 25 kDa
, truncated hsp25
, heat shock 27 kDa protein 1
, 25 kDa heat shock protein
, 25 kDa IAP
, actin polymerization inhibitor
, inhibitor of actin polymerization
, heat-shock protein
, heat shock protein 27