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Browse our MAP3K12 Proteins (MAP3K12)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 12 Proteins (MAP3K12)
On are 6 Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Proteins from 4 different suppliers available. Additionally we are shipping MAP3K12 Antibodies (51) and many more products for this protein. A total of 62 MAP3K12 products are currently listed.
Delta1, DKFZp459K2433, DLK, DLK-1, FA1, map3k12, map3k12a, MEKK12, MGC151798, MUK, pG2, PK, Pref-1, PREF1, zgc:77370, ZOG, ZPK, ZPKP1
list all proteins Gene Name GeneID UniProt
MAP3K12 8788 P80370
MAP3K12 25579 Q63796
MAP3K12 26404 Q60700

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MAP3K12 Proteins (MAP3K12) by Origin

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More Proteins for MAP3K12 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

  1. Results suggest a potential signalling hierarchy between Delta-like 1 (show DLL1 Proteins) and ephrin-B2 (show EFNB2 Proteins) ligands, as neural stem cells adopt the Delta-like 1 (show DLL1 Proteins) phenotype of stem cell maintenance on simultaneous presentation of both signals.

  2. The results indicate the occurrence of epimutation affecting the IG-DMR (show WDR20 Proteins) and the MEG3 (show FAM129B Proteins)-DMR (show WDR20 Proteins) in the two cases, and imply that UPD (show UROD Proteins)(14)mat and related (epi (show TFPI Proteins))genetic aberrations constitute a rare but important underlying factor for Silver-Russell Syndrome

  3. Kaplan-Meier analysis indicated that higher DLK1 (show DLK1 Proteins) levels were associated with shorter survival in Hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients. These results suggest that the serum levels of DLK1 (show DLK1 Proteins) may serve as a prognostic biomarker for HCC (show FAM126A Proteins) patients.

  4. Notch (show NOTCH1 Proteins) pathway activation in endothelial colony forming cells in vivo via co-implanted stromal cells expressing delta-like 1 (show DLL1 Proteins) promotes vasculogenesis.

  5. Data show that the median expression of Jagged-1 (show JAG1 Proteins) protein and delta-like 1 (show DLL1 Proteins) protein (Dll-1 (show DLL1 Proteins)) was significantly higher in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) blasts than in peripheral blood stem cells (PBSCs).

  6. miR (show MLXIP Proteins)-130a inhibited the JNK (show MAPK8 Proteins) pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function.

  7. DLK1 (show DLK1 Proteins) expression diminishes during differentiation of human U937 cells to macrophages.

  8. Data show that preadipocyte factor 1 Pref-1 (show DLK1 Proteins) is probably not a major contributor to gestational diabetes mellitus (GDM) pathophysiology but might directly contribute to triglycerides (TG) metabolism, as well as depend on gestational age and renal function.

  9. These mice show improved glucose tolerance. Taken together, we conclude Pref-1 (show DLK1 Proteins) as a positive regulator of islet beta-cells and insulin (show INS Proteins) production.

  10. Serum levels of Pref-1 (show DLK1 Proteins) were associated with the amount of alcohol consumed during the past 30 days.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

  1. Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (show DAPK3 Proteins) does not appear to have a critical function in axonal degeneration; function appears restricted to soma

  2. This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (show MAP2K4 Proteins)-dependent mechanism in axotomy-induced motoneuron death in neonates

  3. DLK (show DAPK3 Proteins)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.

  4. Abundance of DLK (show DAPK3 Proteins) in turn controlled the levels of downstream JNK (show MAPK8 Proteins) signaling and apoptosis.

  5. DLK (show DAPK3 Proteins) is required for RGC JNK (show MAPK8 Proteins) activation and cell death in a rodent model of optic neuropathy

  6. The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK (show DAPK3 Proteins) is an essential upstream mediator of both of these divergent outcomes in the same cell type.

  7. These data demonstrate that DLK (show DAPK3 Proteins) enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program.

  8. The mixed lineage kinase dual leucine zipper kinase (DLK) selectively regulates the JNK (show MAPK8 Proteins)-based stress response pathway to mediate axon degeneration and neuronal apoptosis without influencing other aspects of JNK (show MAPK8 Proteins) signaling.

  9. ZPK/DLK plays a critical role in naturally occurring programmed cell death of motoneurons.

  10. This study indicated that the DLK (show DAPK3 Proteins)-JNK (show MAPK8 Proteins) pathway facilitates axon formation in neocortical neurons via stage-specific regulation of microtubule stability.

MAP3K12 Protein Profile

Protein Summary

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Alternative names and synonyms associated with MAP3K12

  • mitogen-activated protein kinase kinase kinase 12 (map3k12)
  • mitogen-activated protein kinase kinase kinase 12 (MAP3K12)
  • mitogen-activated protein kinase kinase kinase 12 (map3k12-a)
  • delta-like 1 homolog (Drosophila) (DLK1)
  • mitogen activated protein kinase kinase kinase 12 (Map3k12)
  • mitogen-activated protein kinase kinase kinase 12 (Map3k12)
  • Delta1 protein
  • DKFZp459K2433 protein
  • DLK protein
  • DLK-1 protein
  • FA1 protein
  • map3k12 protein
  • map3k12a protein
  • MEKK12 protein
  • MGC151798 protein
  • MUK protein
  • pG2 protein
  • PK protein
  • Pref-1 protein
  • PREF1 protein
  • zgc:77370 protein
  • ZOG protein
  • ZPK protein
  • ZPKP1 protein

Protein level used designations for MAP3K12

mitogen-activated protein kinase kinase kinase 12 , mitogen activated protein kinase kinase kinase 12 type A , fetal antigen 1 , preadipocyte factor 1 , protein delta homolog 1 , secredeltin , MAPK-upstream kinase , Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase) , Zipper (leucine) protein kinase , dual leucine zipper bearing kinase , dual leucine zipper kinase , leucine-zipper protein kinase , mixed lineage kinase , dual leucine zipper kinase DLK , leucine zipper protein kinase , protein kinase MUK , mitogen activated protein kinase kinase kinase 12 , zipper (leucine) protein kinase

404626 Danio rerio
451940 Pan troglodytes
505427 Bos taurus
607170 Canis lupus familiaris
703059 Macaca mulatta
100064002 Equus caballus
100113430 Xenopus laevis
100172208 Pongo abelii
100358158 Oryctolagus cuniculus
100408788 Callithrix jacchus
100469942 Ailuropoda melanoleuca
100517714 Sus scrofa
8788 Homo sapiens
25579 Rattus norvegicus
7786 Homo sapiens
26404 Mus musculus
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