You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our MAP3K5 Proteins (MAP3K5)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 5 Proteins (MAP3K5)
On are 10 Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) Proteins from 7 different suppliers available. Additionally we are shipping MAP3K5 Antibodies (379) and MAP3K5 Kits (35) and many more products for this protein. A total of 451 MAP3K5 products are currently listed.
7420452D20Rik, ASK, ASK1, MAP3K5, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11
list all proteins Gene Name GeneID UniProt
MAP3K5 293015 O35099
MAP3K5 4217 Q99683

Show all synonyms

MAP3K5 Proteins (MAP3K5) by Origin

Select your origin of interest

More Proteins for MAP3K5 Interaction Partners

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia.

  2. ASK1 mediates 3-NP toxicity and regulates C1q level through the astrocyte TGF-beta (show TGFB1 Proteins).

  3. ASK1 signalling regulates brown and beige adipocyte function.

  4. blocking MPTP (show PTPN2 Proteins)-mediated TNF (show TNF Proteins) signaling through intrathecal administration of TNF (show TNF Proteins)-neutralizing antibody prevented Trx1 (show TXN Proteins) oxidation and downstream ASK1-p38 MAPK (show MAPK14 Proteins) activation

  5. ASK1 deletion in vivo significantly suppresses hyperoxia-induced elevation of inflammatory cytokines (i.e. IL-1beta (show IL1B Proteins) and TNF-alpha (show TNF Proteins)), cell apoptosis in the lung, and recruitment of immune cells

  6. data highlight the importance of ASK1/p38 MAPK (show MAPK14 Proteins) pathway in the brain and identify Klotho (show KL Proteins) as a possible anti-oxidant effector

  7. Data show that deletion of eith (show MAP3K6 Proteins)er MAPKKK5 ASK1 or MAPKKK6 ASK2 in mice promoted the replication of influenza A virus in the lung.

  8. Our results provided the evidence that high-fat diet itself causes cognitive impairment and ASK1 participates in such cognitive impairment.

  9. ASK1 may mediate the teratogenicity of diabetes through activating the JNK1 (show MAPK8 Proteins)/2-ER stress pathway and inhibiting cell cycle progression, thereby impeding the cardiogenesis pathways essential for ventricular septation and outflow tract development.

  10. Study demonstrates that ASK1 is not involved in beta-cell function and dysfunction but controls stress-induced beta-cell death.

Human Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. Cross-talk between arginine methylation and serine phosphorylation in ASK1.PRMT5 (show PRMT5 Proteins) is an ASK1-binding protein.PRMT5 mediates arginine methylation of ASK1.

  2. results suggest that baicalein-mediated ASK1/JNK (show MAPK8 Proteins) activation regulates the mitochondria-dependent apoptosis pathway through the up-regulation of TAp63 and down-regulation of NF-kappaB (show NFKB1 Proteins) and CD74 (show CD74 Proteins)/CD44 (show CD44 Proteins) in B-cell malignancies

  3. curcumin and ABT-737 on HCC (show FAM126A Proteins) cells was investigated for the first time, to the best of our knowledge. It was found that curcumin markedly enhanced the antitumor effects of ABT-737 on HepG2 cells and activate ROS (show ROS1 Proteins)-ASK1-c-Jun N-terminal kinase pathway . .

  4. ASK1 signalling regulates brown and beige adipocyte function.

  5. These results implicate the TNF (show TNF Proteins)/TRAF2 (show TRAF2 Proteins)/ASK1/p38 (show CRK Proteins) kinase pathway in modulating risk of pulmonary complications.

  6. The present findings thus support our notion that ROR1 (show ROR1 Proteins) sustains lung adenocarcinoma survival, at least in part, through direct physical interaction with ASK1

  7. Together, we suggest that 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to potently inhibit human HCC (show FAM126A Proteins) cells.

  8. Data show that the MAPKKK6 ASK2 (show MAP3K6 Proteins), a modulator of MAPKKK5 ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing interferon-beta (IFNB (show IFNB1 Proteins)) expression.

  9. The expression of ASK1 is correlated with the level of claudin-6 (show CLDN6 Proteins) in cervical carcinoma cells and tissues.

  10. ASK1 stabilizes APOBEC3G (show APOBEC3G Proteins) and binds HIV-1 Vif (show BTG1 Proteins), disrupting assemble of the Vif (show BTG1 Proteins)-ubiquitin ligase complex, thus restoring the antiviral activity of APOBEC3g (show APOBEC3G Proteins).

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. These results indicate an important regulatory role of ASK1 in porcine circovirus type 2-induced apoptotic responses.

  2. PP2A (show PPP2R2B Proteins) and AIP1 (show PDCD6IP Proteins) cooperatively induce activation of ASK1-JNK (show MAPK8 Proteins) signaling and vascular endothelial cell apoptosis.

MAP3K5 Protein Profile

Protein Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells\; MAPKKK5 does not activate MAPK/ERK.

Alternative names and synonyms associated with MAP3K5

  • mitogen-activated protein kinase kinase kinase 5 (Map3k5)
  • mitogen-activated protein kinase kinase kinase 5 (MAPKKK5)
  • mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
  • 7420452D20Rik protein
  • ASK protein
  • ASK1 protein
  • MAP3K5 protein
  • MAPKKK5 protein
  • MEKK5 protein
  • mitogen-activated protein kinase kinase kinase 5 protein
  • MUD21.11 protein
  • MUD21_11 protein

Protein level used designations for MAP3K5

ASK-1 , MAPK/ERK kinase kinase 5 , MEK kinase 5 , MEKK 5 , apoptosis signal-regulating kinase 1 , mitogen activated protein kinase kinase kinase 5 , MAP/ERK kinase kinase 5 , apoptosis signal regulating kinase 1 , mitogen-activated protein kinase kinase kinase 5

293015 Mus musculus
836819 Arabidopsis thaliana
4217 Homo sapiens
26408 Mus musculus
100157454 Sus scrofa
537380 Bos taurus
Selected quality suppliers for MAP3K5 Proteins (MAP3K5)
Did you look for something else?