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Browse our MAP3K5 Proteins (MAP3K5)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 5 Proteins (MAP3K5)
On are 11 Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) Proteins from 8 different suppliers available. Additionally we are shipping MAP3K5 Antibodies (376) and MAP3K5 Kits (39) and many more products for this protein. A total of 453 MAP3K5 products are currently listed.
7420452D20Rik, ASK, ASK1, MAP3K5, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11
list all proteins Gene Name GeneID UniProt
MAP3K5 293015 O35099
MAP3K5 4217 Q99683

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MAP3K5 Proteins (MAP3K5) by Origin

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More Proteins for MAP3K5 Interaction Partners

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

  2. These results demonstrate that trans-fatty acids promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA (show F3 Proteins)-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of trans-fatty acids-induced atherosclerosis.

  3. Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (show AKT1 Proteins)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (show AKT1 Proteins) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.

  4. ASK1 MAP kinase (show MAPK1 Proteins) signaling cascade is an important regulator of chondrocyte terminal differentiation.

  5. ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia.

  6. ASK1 mediates 3-NP toxicity and regulates C1q level through the astrocyte TGF-beta (show TGFB1 Proteins).

  7. ASK1 signalling regulates brown and beige adipocyte function.

  8. blocking MPTP (show PTPN2 Proteins)-mediated TNF (show TNF Proteins) signaling through intrathecal administration of TNF (show TNF Proteins)-neutralizing antibody prevented Trx1 (show TXN Proteins) oxidation and downstream ASK1-p38 MAPK (show MAPK14 Proteins) activation

  9. ASK1 deletion in vivo significantly suppresses hyperoxia-induced elevation of inflammatory cytokines (i.e. IL-1beta (show IL1B Proteins) and TNF-alpha (show TNF Proteins)), cell apoptosis in the lung, and recruitment of immune cells

  10. data highlight the importance of ASK1/p38 MAPK (show MAPK14 Proteins) pathway in the brain and identify Klotho (show KL Proteins) as a possible anti-oxidant effector

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. PBL27 interacts with both CERK1 and the MAPK (show MAPK1 Proteins) kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK (show MAPK1 Proteins) kinase activation and disease resistance to Alternaria brassicicola.

Human Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. from the two catalytic cysteines of TRX1 (show MLL Proteins) the residue C32 is responsible for the high-affinity binding of TRX1 (show MLL Proteins) to the ASK1-TRX (show VAC14 Proteins)-binding domain in reducing conditions

  2. Shotgun mass spectrometry and manual validation identified 12 distinct ASK1 phosphosites. Targeted parallel reaction monitoring assays were used to track the phosphorylation dynamics of each confirmed site in response to treatment.

  3. phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta (show YWHAZ Proteins) interacts with the kinase domain of ASK1 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation.

  4. ASK1 MAP kinase (show MAPK1 Proteins) signaling cascade is an important regulator of chondrocyte terminal differentiation.

  5. Pretreatment by IRE1 (show ERN1 Proteins) agonist tunicamycin or JNK (show MAPK8 Proteins) agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1 (show ERN1 Proteins)-ASK1-JNK (show MAPK8 Proteins) pathway

  6. Our results thus suggest that GSK-3beta is a key factor involved in ASK1 activation and reactive oxygen species-induced cell death.

  7. the data show that miRNA-mediated down-regulation of ASK1 protects mesenchymal stem cells during post-transplantation, leading to an increase in the efficacy of MSC (show MSC Proteins)-based cell therapy.

  8. Cross-talk between arginine methylation and serine phosphorylation in ASK1.PRMT5 (show PRMT5 Proteins) is an ASK1-binding protein.PRMT5 mediates arginine methylation of ASK1.

  9. results suggest that baicalein-mediated ASK1/JNK (show MAPK8 Proteins) activation regulates the mitochondria-dependent apoptosis pathway through the up-regulation of TAp63 and down-regulation of NF-kappaB (show NFKB1 Proteins) and CD74 (show CD74 Proteins)/CD44 (show CD44 Proteins) in B-cell malignancies

  10. curcumin and ABT-737 on HCC (show FAM126A Proteins) cells was investigated for the first time, to the best of our knowledge. It was found that curcumin markedly enhanced the antitumor effects of ABT-737 on HepG2 cells and activate ROS (show ROS1 Proteins)-ASK1-c-Jun N-terminal kinase pathway . .

MAP3K5 Protein Profile

Protein Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells\; MAPKKK5 does not activate MAPK/ERK.

Alternative names and synonyms associated with MAP3K5

  • mitogen-activated protein kinase kinase kinase 5 (Map3k5)
  • mitogen-activated protein kinase kinase kinase 5 (MAPKKK5)
  • mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
  • 7420452D20Rik protein
  • ASK protein
  • ASK1 protein
  • MAP3K5 protein
  • MAPKKK5 protein
  • MEKK5 protein
  • mitogen-activated protein kinase kinase kinase 5 protein
  • MUD21.11 protein
  • MUD21_11 protein

Protein level used designations for MAP3K5

ASK-1 , MAPK/ERK kinase kinase 5 , MEK kinase 5 , MEKK 5 , apoptosis signal-regulating kinase 1 , mitogen activated protein kinase kinase kinase 5 , MAP/ERK kinase kinase 5 , apoptosis signal regulating kinase 1 , mitogen-activated protein kinase kinase kinase 5

293015 Mus musculus
836819 Arabidopsis thaliana
4217 Homo sapiens
26408 Mus musculus
100157454 Sus scrofa
537380 Bos taurus
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