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Human MCL-1 Protein expressed in Escherichia coli (E. coli) - ABIN1098214
Bae, Leo, Hsu, Hsueh: MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. in The Journal of biological chemistry 2000
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High Mcl-1 levels enhanced mTOR (show FRAP1 Proteins) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Proteins) T cells.
Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.
Data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation.
a mechanism of inverse coregulation between BECN1 (show BECN1 Proteins) and MCL1 significantly contributes to their opposing roles in tumorigenesis
There is a non-redundant pathway linking IL-15 (show IL15 Proteins) to Mcl1 in the maintenance of NK cells and innate immune responses in vivo.
Authors recognize MCL-1 as the essential survival factor required for conservation of the postnatal PMF (show PRB1 Proteins) pool, growing follicle survival and effective oocyte mitochondrial function.
Tax (show CNTN2 Proteins) interacted with and activated TRAF6 (show TRAF6 Proteins), and triggered its mitochondrial localization, where it conjugated four carboxyl-terminal lysine residues of MCL-1 with lysine 63-linked polyubiquitin (show UBB Proteins) chains
deletion of Mir155 prevents Fas (show FAS Proteins)-induced hepatocyte apoptosis and liver injury through the up-regulation of Mcl1.
Inverse co-regulation of Beclin 1 (show BECN1 Proteins) and Mcl-1 represents a mechanism of functional counteraction in cancer.
miR (show MLXIP Proteins)-29a is involved in the pathogenesis of ulcerative colitis by regulating intestinal epithelial apoptosis via Mcl-1.
Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1 (show MAP2K1 Proteins)/2 inhibitors in melanoma.
identify high copy number gain of MCL1 (chromosome 1q) and loss of CDKN2A (P16, chromosome 9p) in metastatic BRAF
Our data demonstrate a critical role of Mcl-1 in Her2 (show ERBB2 Proteins)-positive BC cell survival under hypoxic conditions and provide the preclinical framework for the therapeutic use of novel Mcl-1- targeting agents to improve patient outcome in breast cancer .
miR (show MLXIP Proteins)-193b sensitizes MCF-7/DOXR cells to doxorubicin through a mechanism involving the downregulation of MCL-1
Co-administration of the mTORC1/TORC2 (show CRTC2 Proteins) inhibitor INK128 and the Bcl-2 (show BCL2 Proteins)/Bcl-xL (show BCL2L1 Proteins) antagonist ABT-737 kills human myeloid leukemia (show BCL11A Proteins) cells through Mcl-1 down-regulation and AKT (show AKT1 Proteins) inactivation.
Bak (show BAK1 Proteins) activates upon loss of anti-apoptotic Bcl-XL (show BCL2L1 Proteins) and Mcl-1 but in the absence of active BH3-only (show BBC3 Proteins) proteins.
LA provoked a down regulation of two anti-apoptotic proteins, Mcl-1 and Bcl-xL (show BCL2L1 Proteins) protein and a strong induction of the BH3-only (show BBC3 Proteins) protein Bim (show BCL2L11 Proteins).
AZD5582 draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 (show BIRC2 Proteins) and XIAP (show XIAP Proteins) in human pancreatic cancer
the FoxM1 (show FOXM1 Proteins)/Mcl-1 pathway may overcome cispaltin resistance of gastric cancer and provide a new therapeutic target for the treatment of gastric cancer
Upregulation of miR (show MLXIP Proteins)-125b inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. miR (show MLXIP Proteins)-125b elicits these responses by directly targeting MCL1, which results in a marked reduction in MCL1 expression.
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
bcl-2-related protein EAT/mcl1
, induced myeloid leukemia cell differentiation protein Mcl-1 homolog
, bcl-2-like protein 3
, induced myeloid leukemia cell differentiation protein Mcl-1
, myeloid cell leukemia ES
, myeloid cell leukemia protein 1