Browse our MCL-1 Proteins (MCL1)

Full name:
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Proteins (MCL1)
On www.antibodies-online.com are 13 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Proteins from 6 different suppliers available. Additionally we are shipping MCL-1 Antibodies (340) and MCL-1 Kits (21) and many more products for this protein. A total of 394 MCL-1 products are currently listed.
Synonyms:
AW556805, bcl2-L-3, BCL2L3, EAT, mcl-1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM
list all proteins Gene Name GeneID UniProt
MCL1 17210 P97287
Rat MCL1 MCL1 60430 Q9Z1P3
MCL1 4170 Q07820

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MCL-1 Proteins (MCL1) by Origin

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Top referenced MCL-1 Proteins

  1. Human MCL-1 Protein expressed in Escherichia coli (E. coli) - ABIN1098214 : Bae, Leo, Hsu, Hsueh: MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. in The Journal of biological chemistry 2000 (PubMed)
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More Proteins for MCL-1 Interaction Partners

Mouse (Murine) Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells

  2. BCL-XL (show BCL2L1 Proteins) expression promotes survival of immature B cells, expression of BCL-2 (show BCL2 Proteins) is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development.

  3. miR (show MLXIP Proteins)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.

  4. GSK3B-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.

  5. Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (show MAPK1 Proteins) signaling pathway is the primary mediator of Mcl-1 expression.

  6. MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell

  7. Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins) overexpressing B cell progenitors.

  8. MCL-1 loss in early B-lymphoid progenitors delayed MYC (show MYC Proteins)-driven lymphomagenesis.

  9. High Mcl-1 levels enhanced mTOR (show FRAP1 Proteins) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Proteins) T cells.

  10. Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.

Human Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells

  2. MACC1 (show MACC1 Proteins) regulates Fas (show FAS Proteins) mediated apoptosis through STAT1 (show STAT1 Proteins)/3 - Mcl-1 signaling in solid cancers.

  3. dual inhibition of Mcl-1 via decreased expression and the induction of its antagonist NOXA (show PMAIP1 Proteins) by the combination of carfilzomib and TG02 is active in myeloma

  4. Our findings establish a pivotal role for Mcl-1 degradation in the response of colon cancer cells to targeted therapeutics, and they provide a useful rational platform to develop Mcl-1-targeting agents that can overcome drug resistance

  5. comparison of patient samples prior to and following sunitinib treatment suggested that increases in MCL-1 levels and mTORC1 activity correlate with resistance to sunitinib in patients.

  6. Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency

  7. review summarizes the role of MCL-1 in B- and T-cell lymphoma

  8. Inhibition of SPHK1 (show SPHK1 Proteins) in human acute myeloid leukemia (show BCL11A Proteins) cells induces MCL1 degradation and caspase (show CASP3 Proteins)-dependent cell death.

  9. bone marrow stroma is capable of inducing Mcl-1 dependence through the production of the plasma cell survival cytokine interleukin-6 (IL-6 (show IL6 Proteins)).

  10. Mcl-1 is required for endothelial cell survival and the regulation of Ang II (show AGT Proteins)-induced endothelial cell death.

MCL-1 (MCL1) Protein Profile

Protein Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Alternative names and synonyms associated with MCL-1 (MCL1)

  • myeloid cell leukemia sequence 1 (Mcl1)
  • myeloid cell leukemia sequence 1 (BCL2-related) (MCL1)
  • AW556805 protein
  • bcl2-L-3 protein
  • BCL2L3 protein
  • EAT protein
  • mcl-1 protein
  • MCL1-ES protein
  • mcl1/EAT protein
  • MCL1L protein
  • MCL1S protein
  • TM protein

Protein level used designations for MCL1

bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog , bcl-2-like protein 3 , induced myeloid leukemia cell differentiation protein Mcl-1 , myeloid cell leukemia ES , myeloid cell leukemia protein 1

GENE ID SPECIES
17210 Mus musculus
60430 Rattus norvegicus
4170 Homo sapiens
403537 Canis lupus familiaris
493970 Felis catus
397648 Sus scrofa
788087 Bos taurus
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