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Browse our MCL-1 Proteins (MCL1)

Full name:
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Proteins (MCL1)
On www.antibodies-online.com are 12 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Proteins from 5 different suppliers available. Additionally we are shipping MCL-1 Antibodies (344) and MCL-1 Kits (18) and many more products for this protein. A total of 392 MCL-1 products are currently listed.
Synonyms:
AW556805, bcl2-L-3, BCL2L3, EAT, mcl-1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM
list all proteins Gene Name GeneID UniProt
MCL1 17210 P97287
Rat MCL1 MCL1 60430 Q9Z1P3
MCL1 4170 Q07820

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MCL-1 Proteins (MCL1) by Origin

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Top referenced MCL-1 Proteins

  1. Human MCL-1 Protein expressed in Escherichia coli (E. coli) - ABIN1098214 : Bae, Leo, Hsu, Hsueh: MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN1098214

More Proteins for MCL-1 Interaction Partners

Mouse (Murine) Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (show MAPK1 Proteins) signaling pathway is the primary mediator of Mcl-1 expression.

  2. MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell

  3. Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins) overexpressing B cell progenitors.

  4. MCL-1 loss in early B-lymphoid progenitors delayed MYC (show MYC Proteins)-driven lymphomagenesis.

  5. High Mcl-1 levels enhanced mTOR (show FRAP1 Proteins) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Proteins) T cells.

  6. Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.

  7. Data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation.

  8. a mechanism of inverse coregulation between BECN1 (show BECN1 Proteins) and MCL1 significantly contributes to their opposing roles in tumorigenesis

  9. There is a non-redundant pathway linking IL-15 (show IL15 Proteins) to Mcl1 in the maintenance of NK cells and innate immune responses in vivo.

  10. Authors recognize MCL-1 as the essential survival factor required for conservation of the postnatal PMF (show PRB1 Proteins) pool, growing follicle survival and effective oocyte mitochondrial function.

Human Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. demonstrate that downregulation of PHD3 (show EGLN3 Proteins) augments metastatic spread in human colorectal cancer and identify MCL-1 as a novel downstream effector of oxygen sensing

  2. addition of imperatorin significantly reversed the resistance to cisplatin in cisplatin-resistant HCC (show FAM126A Proteins) cells, which was Mcl-1 dependent

  3. In particular, the treatment with the cocrystal MetH(2 (show ADAMTS8 Proteins))(++)*2DCA(-) induced a synergistic apoptotic cell death coupled to a marked down-modulation of the anti-apoptotic Mcl-1 protein.

  4. these findings provided that in lung cancer cells, tumor suppressor miR (show MLXIP Proteins)-451 enhanced DPP (show DSPP Proteins) sensitivity via regulation of Mcl-1 expression, which could be served as a novel therapeutic target for the treatment of chemotherapy resistant in lung cancer.

  5. This review covers findings on how the mitochondrial fission and fusion machinery may intersect apoptotic pathways focusing on recent advances on the key role played by Mcl-1. [review]

  6. However, because mitotic degradation of Mcl-1 appears not to be under the control of an E3 ligase, we suggest that the notion of network crosstalk is used with caution.

  7. Results indicated that the pro-survival Bcl-2 (show BCL2 Proteins) family protein MCL-1 may be the key target for reversing the cisplatin-resistance in non-small cell lung cancer cells.

  8. we demonstrate that M. tuberculosis infection leads to downregulation of miR-17 and concomitant upregulation of its targets Mcl-1 and STAT3 (show STAT3 Proteins), a transcriptional activator of Mcl-1. Forced expression of miR-17 reduces expression of Mcl-1 and STAT3 (show STAT3 Proteins) and also the interaction between Mcl-1 and Beclin-1 (show BECN1 Proteins)

  9. By the pharmacologic targeting of BCL2 (show BCL2 Proteins), MCL1, and BCL-XL (show BCL2L1 Proteins), we demonstrated that diffuse large B-cell lymphoma can be divided into BCL2 (show BCL2 Proteins)-dependent and MCL1-dependent subgroups with a less pronounced role left for BCL-XL (show BCL2L1 Proteins).

  10. Inhibition of Mcl-1 is required for apoptosis induction in ATRA differentiation-responsive AML (show RUNX1 Proteins) cells. ATRA and sorafenib can be developed as a novel drug combination therapy for AML (show RUNX1 Proteins) patients because this drug combination augments apoptosis by inhibiting Bcl-2 (show BCL2 Proteins) and Mcl-1.

MCL-1 (MCL1) Protein Profile

Protein Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Alternative names and synonyms associated with MCL-1 (MCL1)

  • myeloid cell leukemia sequence 1 (Mcl1)
  • myeloid cell leukemia sequence 1 (BCL2-related) (MCL1)
  • AW556805 protein
  • bcl2-L-3 protein
  • BCL2L3 protein
  • EAT protein
  • mcl-1 protein
  • MCL1-ES protein
  • mcl1/EAT protein
  • MCL1L protein
  • MCL1S protein
  • TM protein

Protein level used designations for MCL1

bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog , bcl-2-like protein 3 , induced myeloid leukemia cell differentiation protein Mcl-1 , myeloid cell leukemia ES , myeloid cell leukemia protein 1

GENE ID SPECIES
17210 Mus musculus
60430 Rattus norvegicus
4170 Homo sapiens
403537 Canis lupus familiaris
493970 Felis catus
397648 Sus scrofa
788087 Bos taurus
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