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Browse our MKNK1 Proteins (MKNK1)

Full name:
MAP Kinase Interacting serine/threonine Kinase 1 Proteins (MKNK1)
On www.antibodies-online.com are 10 MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Proteins from 6 different suppliers available. Additionally we are shipping MKNK1 Antibodies (133) and MKNK1 Kits (6) and many more products for this protein. A total of 161 MKNK1 products are currently listed.
Synonyms:
2410048M24Rik, Erk-1, Erk1, Ert2, Esrk1, MAPK1, MKNK1, Mnk1, Mtap2k, p44, p44erk1, p44mapk, Prkm3, zgc:171912
list all proteins Gene Name GeneID UniProt
MKNK1 8569 Q9BUB5
MKNK1 17346 O08605
MKNK1 500526 Q4G050

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MKNK1 Proteins (MKNK1) by Origin

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More Proteins for MKNK1 Interaction Partners

Human MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) interaction partners

  1. data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Proteins)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (show EIF4E Proteins) phosphorylation in vitro and in vivo.

  2. Data suggest MNK1/MNK2 (show MKNK2 Proteins) stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (show EIF4E Proteins) (via decreased binding to eIF4G (show EIF4G1 Proteins)).

  3. Simultaneous targeting of androgen receptor (show AR Proteins) and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines.

  4. MNK1 and MNK2 (show MKNK2 Proteins) inhibition ablates eIF4E1 (show EIF4E Proteins) phosphorylation and concurrently enhances eIF4E3 (show EIF4E3 Proteins) expression in diffuse large B-cell lymphoma.

  5. Data show that interferon-gamma (show IFNG Proteins) regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E (show EIF4E Proteins)).

  6. Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML).

  7. Authors show that MNK (show ATP7A Proteins) regulates SRPK (show SRPK1 Proteins) via mTOR (show FRAP1 Proteins) and AKT (show AKT1 Proteins).

  8. ERK1/2 signal induced MNK (show ATP7A Proteins) catalytic activity enabled enterovirus type 1 internal ribosomal entry site-mediated translation/host cell cytotoxicity through negative regulation of the Ser (show SIGLEC1 Proteins)/Arg (SR)-rich protein kinase (show CDK7 Proteins) (SRPK (show SRPK1 Proteins)).

  9. These data indicate multiple myeloma cells exploit the MNK (show ATP7A Proteins)/eIF-4E (show EIF4E Proteins) pathway for selective mRNA translation without enhancing global translation and risking ER stress.

  10. High expression of p-Mnk1 and p-eIF4E (show EIF4E Proteins) might be novel valuable biomarkers to predict poor prognosis of nasopharyngeal carcinoma.

Mouse (Murine) MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) interaction partners

  1. RKIP (show PEBP1 Proteins) knockdown promotes ERK1 (show MAPK3 Proteins) and PPAR gamma (show PPARG Proteins) activation during adipogenesis.

  2. data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Proteins)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (show EIF4E Proteins) phosphorylation in vitro and in vivo.

  3. Results indicate that methanol extract of Thunbergia alata (MTA (show DNMT1 Proteins)) selectively inhibits the excessive production of inflammatory mediators in macrophages by reducing phosphorylation of extracellular signalregulated kinase (ERK (show EPHB2 Proteins)) and signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)).

  4. Neuroprotective effects of oleoylethanolamide on cerebral ischemia may be attributed to its antiapoptotic property achieved, at least in part, through the PPARalpha signaling and inhibition of both TLR4/NF-kappaB and ERK1/2 signaling pathways.

  5. These results indicated that the activation of the ERK1/2 signal transduction pathway may have an important role in glucosestimulated insulin (show INS Proteins) secretion in betaTC6 cells.

  6. PI3K, MAPK/ERK (show MAPK1 Proteins) 1 (show MAPK3 Proteins)/2, and p38 (show CRK Proteins)-signaling proteins are not the main regulators of local production of erythropoietin (show EPO Proteins) after 30% loss of circulating blood volume.

  7. Lipopolysaccharides significantly up-regulated RANKL (show TNFSF11 Proteins) expression and activated the ERK1/2 pathway to induce IL-6 (show IL6 Proteins) mRNA expression and protein synthesis in MLO-Y4 cells.

  8. RACK1 (show GNB2L1 Proteins) plays an important role in the maintenance of morphine conditioned place preference, likely via activation of ERK (show EPHB2 Proteins)-CREB (show CREB1 Proteins) pathway in hippocampus.

  9. cellular retinoic acid binding protein 1 (Crabp1 (show CRABP1 Proteins)) mediates the non-genomic activity of atRA, and identify two compounds as the ligands of Crabp1 (show CRABP1 Proteins) to rapidly and RAR (show RARA Proteins)-independently activate extracellular signal regulated kinase 1/2 (show MAPK3 Proteins) (ERK1/2).

  10. the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.

MKNK1 Protein Profile

Protein Summary

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.

Alternative names and synonyms associated with MKNK1

  • MAP kinase interacting serine/threonine kinase 1 (MKNK1)
  • MAP kinase interacting serine/threonine kinase 1 (mknk1)
  • MAP kinase-interacting serine/threonine kinase 1 (Mknk1)
  • mitogen activated protein kinase 3 (Mapk3)
  • mitogen-activated protein kinase 3 (Mapk3)
  • 2410048M24Rik protein
  • Erk-1 protein
  • Erk1 protein
  • Ert2 protein
  • Esrk1 protein
  • MAPK1 protein
  • MKNK1 protein
  • Mnk1 protein
  • Mtap2k protein
  • p44 protein
  • p44erk1 protein
  • p44mapk protein
  • Prkm3 protein
  • zgc:171912 protein

Protein level used designations for MKNK1

MAP kinase interacting serine/threonine kinase 1 , MAP kinase-interacting serine/threonine-protein kinase 1 , MAP kinase signal-integrating kinase 1 , MAPK signal-integrating kinase 1 , mnk1 , MAP kinase 1 , MAP kinase 3 , MAP kinase isoform p44 , MAPK 1 , MAPK 3 , extracellular signal-regulated kinase 1 , insulin-stimulated MAP2 kinase , microtubule-associated protein 2 kinase , mitogen-activated 3 , mitogen-activated protein kinase 1 , mitogen-activated protein kinase 3 , p44 MAP kinase , pp42/MAP kinase

GENE ID SPECIES
469189 Pan troglodytes
555974 Danio rerio
771961 Gallus gallus
8569 Homo sapiens
525647 Bos taurus
17346 Mus musculus
500526 Rattus norvegicus
50689 Rattus norvegicus
26417 Mus musculus
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