Browse our MKNK1 Proteins (MKNK1)

Full name:
MAP Kinase Interacting serine/threonine Kinase 1 Proteins (MKNK1)
On are 11 MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Proteins from 6 different suppliers available. Additionally we are shipping MKNK1 Antibodies (135) and MKNK1 Kits (6) and many more products for this protein. A total of 165 MKNK1 products are currently listed.
2410048M24Rik, Erk-1, Erk1, Ert2, Esrk1, MAPK1, MKNK1, Mnk1, Mtap2k, p44, p44erk1, p44mapk, Prkm3, zgc:171912
list all proteins Gene Name GeneID UniProt
MKNK1 8569 Q9BUB5
MKNK1 17346 O08605
MKNK1 500526 Q4G050

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MKNK1 Proteins (MKNK1) by Origin

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Human MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) interaction partners

  1. MNK1 encodes a Ser/Thr protein kinase that interacts with extracellular signal-regulated kinase 1 (show MAPK3 Proteins) and p38 mitogen-activated protein kinase (show MAPK14 Proteins), a pathway that is involved in Blood Pressure regulation through norepinephrine and angiotensin II.

  2. Data show that galeterone (gal (show GAL Proteins)) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E (show EIF4E Proteins) axis.

  3. data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Proteins)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (show EIF4E Proteins) phosphorylation in vitro and in vivo.

  4. Data suggest MNK1/MNK2 (show MKNK2 Proteins) stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (show EIF4E Proteins) (via decreased binding to eIF4G (show EIF4G1 Proteins)).

  5. Simultaneous targeting of androgen receptor (show AR Proteins) and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines.

  6. MNK1 and MNK2 (show MKNK2 Proteins) inhibition ablates eIF4E1 (show EIF4E Proteins) phosphorylation and concurrently enhances eIF4E3 (show EIF4E3 Proteins) expression in diffuse large B-cell lymphoma.

  7. Data show that interferon-gamma (show IFNG Proteins) regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E (show EIF4E Proteins)).

  8. Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML).

  9. Authors show that MNK (show ATP7A Proteins) regulates SRPK (show SRPK1 Proteins) via mTOR (show FRAP1 Proteins) and AKT (show AKT1 Proteins).

  10. ERK1/2 signal induced MNK (show ATP7A Proteins) catalytic activity enabled enterovirus type 1 internal ribosomal entry site-mediated translation/host cell cytotoxicity through negative regulation of the Ser (show SIGLEC1 Proteins)/Arg (SR)-rich protein kinase (show CDK7 Proteins) (SRPK (show SRPK1 Proteins)).

Mouse (Murine) MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) interaction partners

  1. Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.

  2. Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.

  3. ERK1 (show MAPK3 Proteins) underexpression is associated with obesity.

  4. retinoschisin (show RS1 Proteins) is a novel regulator of MAP kinase (show MAPK1 Proteins) signalling and exerts an anti-apoptotic effect on retinal cells.

  5. Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 Proteins) with an inducible Col2a1 (show COL2A1 Proteins)-Cre caused premature production of pErk1/2 and Mmp13 (show MMP13 Proteins) in the growth plate.

  6. The progress of neurogenesis depended on sustained ERK phosphorylation and resulted in ERK1/2 translocation to the nucleus.

  7. Mirtazapine suppressed 5-HT-mediated TGF-beta1/Smad3 and ERK1/2 signaling pathways as well as oxidative stress that contribute to the progression of liver fibrosis.

  8. The kinase TPL2 (show MAP3K8 Proteins) activates ERK (show EPHB2 Proteins) and p38 (show CRK Proteins) signaling to promote neutrophilic inflammation

  9. MNK1 participates in mediating high-fat diet-induced insulin (show INS Proteins) resistance. Our findings reveal distinct roles for the MNKs in a novel area of disease biology

  10. HAS2 (show HAS2 Proteins)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (show MAPK3 Proteins)/EGR1 (show EGR1 Proteins) signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (show TGFB1 Proteins)-stimulated CD44V6/ERK (show EPHB2 Proteins)/EGR1 (show EGR1 Proteins) signaling.

MKNK1 Protein Profile

Protein Summary

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.

Alternative names and synonyms associated with MKNK1

  • MAP kinase interacting serine/threonine kinase 1 (MKNK1)
  • MAP kinase interacting serine/threonine kinase 1 (mknk1)
  • MAP kinase-interacting serine/threonine kinase 1 (Mknk1)
  • mitogen activated protein kinase 3 (Mapk3)
  • mitogen-activated protein kinase 3 (Mapk3)
  • 2410048M24Rik protein
  • Erk-1 protein
  • Erk1 protein
  • Ert2 protein
  • Esrk1 protein
  • MAPK1 protein
  • MKNK1 protein
  • Mnk1 protein
  • Mtap2k protein
  • p44 protein
  • p44erk1 protein
  • p44mapk protein
  • Prkm3 protein
  • zgc:171912 protein

Protein level used designations for MKNK1

MAP kinase interacting serine/threonine kinase 1 , MAP kinase-interacting serine/threonine-protein kinase 1 , MAP kinase signal-integrating kinase 1 , MAPK signal-integrating kinase 1 , mnk1 , MAP kinase 1 , MAP kinase 3 , MAP kinase isoform p44 , MAPK 1 , MAPK 3 , extracellular signal-regulated kinase 1 , insulin-stimulated MAP2 kinase , microtubule-associated protein 2 kinase , mitogen-activated 3 , mitogen-activated protein kinase 1 , mitogen-activated protein kinase 3 , p44 MAP kinase , pp42/MAP kinase

469189 Pan troglodytes
555974 Danio rerio
771961 Gallus gallus
8569 Homo sapiens
525647 Bos taurus
17346 Mus musculus
500526 Rattus norvegicus
50689 Rattus norvegicus
26417 Mus musculus
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