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Browse our PPARG Proteins (PPARG)

Full name:
Peroxisome Proliferator-Activated Receptor gamma Proteins (PPARG)
On are 48 Peroxisome Proliferator-Activated Receptor gamma (PPARG) Proteins from 15 different suppliers available. Additionally we are shipping PPARG Antibodies (298) and PPARG Kits (83) and many more products for this protein. A total of 446 PPARG products are currently listed.
list all proteins Gene Name GeneID UniProt
PPARG 19016 P37238
PPARG 5468 P37231
PPARG 25664 O88275

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PPARG Proteins (PPARG) by Origin

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Top referenced PPARG Proteins

  1. Human PPARG Protein expressed in Escherichia coli (E. coli) - ABIN667157 : Berger, Moller: The mechanisms of action of PPARs. in Annual review of medicine 2002 (PubMed)
    Show all 2 references for ABIN667157

More Proteins for PPARG Interaction Partners

Mouse (Murine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

  1. Data suggest that PPARgamma plays role in protecting skeletal muscle cells against oxidative stress/myositis caused by excessive exercise or oxidants; PPARgamma appears to exert anti-inflammatory and anti-oxidant activity via inhibition of the MAP kinase/NFkappaB signaling pathway.

  2. TGF-beta1 (show TGFB1 Proteins)-induced inhibition of PPARgamma transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3 (show SMAD3 Proteins), mSin3A and HDAC1 (show HDAC1 Proteins) at the PPARgamma promoter.

  3. The P (show TRPV4 Proteins)PARgamma inhibitor T0070907 enhanced the basal expression of TRPV4 and protected RAW264. (show TRPV4 Proteins)7 cells from oxLDL-induced TRPV4 down-regulation. TRPV4 was widely expressed in RAW 264.7 cells. oxLDL induced the down-regulation of TRPV4 expression through its actions on PPARgamma.

  4. PPAR-gamma over-expression perturbs the intracellular calcium homeostasis in cardiomyocytes which contribute to the ventricular arrhythmias and cardiac sudden death in transgenic -PPAR-gamma mice.

  5. P. aculeata is effective to improve insulin (show INS Proteins) resistance in a mouse model of obesity and this effect seems to involve the antioxidant and anti-inflammatory mechanisms through the increase in PPARgamma/CuZn-SOD (show SOD1 Proteins) axis expression.

  6. LPS (show TLR4 Proteins)-induced inflammation is potently compromised by emodin very likely through the PPARgamma-dependent inactivation of NF-kappaB (show NFKB1 Proteins)

  7. Treatment of an Alzheimer's disease mouse model with genistein results in a remarkable and rapid improvement in various parameters of cognition; a lowering of Abeta (show APP Proteins) levels in brain, in the number and the area of amyloid plaques (confirmed in vivo by positron emission tomography) as well as in microglial reactivity; and incubation of primary astrocytes with genistein results in a PPARgamma-mediated increased release of ...

  8. PPARgamma interacted with Mark4 (show MARK4 Proteins) and inhibited the stimulating effect of Mark4 (show MARK4 Proteins) on oxidative stress and inflammation.

  9. PPARgamma plays an important role in sustaining angiogenic potential in mature pulmonary microvascular endothelial cells through E2F1 (show E2F1 Proteins)-mediated gene regulation.

  10. Rosiglitazone modulated the inflammatory response and increased bacterial clearance through PPARgamma activation and NET formation, combining immunomodulatory and host-dependent anti-bacterial effects and, therefore, warrants further study as a potential therapeutic agent in sepsis.

Human Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

  1. Data suggest that PPARgamma plays role in protecting skeletal muscle cells against oxidative stress/myositis caused by excessive exercise or oxidants; PPARgamma appears to exert anti-inflammatory and anti-oxidant activity via inhibition of the MAP kinase/NFkappaB signaling pathway.

  2. combined PPARgamma C1431T, PGC-1alpha G482S, and LXRalpha (show NR1H3 Proteins) -115G/A polymorphisms increase the risk of coronary artery disease and predicted the severity of coronary atherosclerosis in Thais

  3. Distinct gene regulatory programs define the inhibitory effects of liver X receptors, NR1H2 (show NR1H2 Proteins)/NR1H3 (show NR1H3 Proteins) and PPARG on cancer cell proliferation.

  4. Our results support an important association between rs1805192 minor allele (G allele) of PPARG and increased diabetic nephropathy (DN) risk in Chinese Han; the interaction analysis showed a combined effect of interaction between rs1805192 and abdominal obesity on DN risk.

  5. The results of this meta-analysis indicated the influence of ethnicity in determining gestational diabetes mellitus susceptibility, in the presence of a Pro12Ala polymorphism in PPARgamma.

  6. The findings suggest that miR (show MLXIP Proteins)-130b promotes the proliferation and invasion of glioma cells by inhibiting PPARgamma.

  7. The anti-proliferative and pro-apoptotic actions of pioglitazone in human uterine leiomyosarcoma cells were not PPARgamma dependent.

  8. PPARG polymorphism is associated with the risk of coronary heart disease.

  9. data show that RXRalpha (show RXRA Proteins) expression is increased in miscarriage in endometrial glands and correlation analysis showed that negative correlation between RXRalpha (show RXRA Proteins) and PPARgamma disappears in miscarriage. This shift is supposable responsible for the loss of regular function in trophoblast and embryonic tissue.

  10. in systemic insulin (show INS Proteins) sensitivity (McAuley's ISI: Delta0.98 M/mU/L cf. basal). CONCLUSION: Exercise participation suppressed M1 markers and induced M2 markers in monocytes, potentially via PPARgamma-triggered signalling, and these effects may contribute (perhaps via priming of monocytes for differentiation into M2 tissue-macrophages) to improved systemic insulin (show INS Proteins) sensitivity in exercising participants. These findings prov...

Pig (Porcine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

  1. Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (show MSTN Proteins) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (show MYOD1 Proteins) expression.

  2. PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Proteins) activation mediated PPARgamma phosphorylation.

  3. Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Proteins)) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Proteins) regulation pattern for PPARgamma to that of ATGL (show PNPLA2 Proteins) in adipocytes.

  4. The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.

  5. Increasing dietary DE linearly enhanced the expression of PPARgamma in adipose tissues but not skeletal muscle of Rongchang piglets.

  6. These results suggest that trans-10, cis (show CISH Proteins)-12-conjugated linoleic acid can modulate TNF-alpha (show TNF Proteins) production and NF-kappa B (show NFKB1 Proteins) expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.

  7. The results indicated that PPARgamma gene was significantly associated with litter size in pigs.

  8. Results indicated that PPARgamma is an essential regulatory factor for the transcriptional activity of ERp44 (show ERP44 Proteins), which in turn controls the secretion of adiponectin (show ADIPOQ Proteins).

  9. Endothelium on the pathosusceptible side of the aortic valve leaflet is responds to hypercholesterolemia with activation of a PPAR-gamma pathway.

  10. PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.

Cow (Bovine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

  1. PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.

  2. An Asp7Gly substitution in PPARG is associated with adiposity.

  3. upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age

  4. Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (show CEBPB Proteins) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (show FFAR2 Proteins) gene expression in adipocytes.

  5. A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.

  6. study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG and SP1 (show SP1 Proteins) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

  7. Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.

  8. oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells

  9. The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.

  10. Intramammary infection elicited a strong transcriptomic response, leading to potent activation of pro-inflammatory pathways that were associated with a marked inhibition of lipid synthesis, stress-activated kinase signaling cascades, and PPAR (show PPARA Proteins) signaling.

Rhesus Monkey Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

  1. study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (show PTPN2 Proteins), only the lesioned putamen had increased PPAR-gamma

  2. Aleglitazar, a dual PPARalpha (show PPARA Proteins)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.

Rabbit Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

  1. siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.

  2. vitamin E supplementation affords protection by decreasing MMP-1 (show MMP1 Proteins) and increasing PPARg, GSTa (show GSTa2 Proteins), and ABCA1 (show ABCA1 Proteins) levels in aortae of rabbits fed a cholesterol-rich diet

  3. Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.

  4. PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (show PTGS2 Proteins) down-regulation and 3beta-HSD (show HAL Proteins) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.

  5. In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.

  6. Tongxinluo can inhibit the expression of MMP-3 (show MMP3 Proteins) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.

  7. Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Proteins) and up-regulates PPARgamma and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.

  8. Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (show PIK3CA Proteins), Akt (show AKT1 Proteins), and eNOS (show NOS3 Proteins) pathway in a rabbit model of myocardial infarction.

PPARG Protein Profile

Protein Summary

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

Alternative names and synonyms associated with PPARG

  • peroxisome proliferator-activated receptor gamma (PPARG)
  • peroxisome proliferator activated receptor gamma (Pparg)
  • peroxisome proliferator-activated receptor gamma (Pparg)
  • peroxisome proliferator-activated receptor gamma (pparg)
  • PPAR gamma 3 (LOC100008892)
  • CIMT1 protein
  • GLM1 protein
  • NR1C3 protein
  • PPAR-GAMMA protein
  • PPAR-gamma2 protein
  • PPARG protein
  • PPARG1 protein
  • PPARG2 protein
  • PPAR gamma protein
  • PPARGAMMA protein
  • PPARgamma2 protein
  • xPPAR-gamma protein

Protein level used designations for PPARG

peroxisome proliferator activated receptor gamma , peroxisome proliferative activated receptor gamma , peroxisome proliferator-activated receptor gamma , peroxisome proliferator activator receptor gamma , nuclear receptor subfamily 1 group C member 3 , peroxisome proliferator activated receptor gamma 2 , peroxisome proliferator activated receptor gamma 4 , Nuclear receptor subfamily 1 group C member 3 , PPAR gamma , PPAR-gamma , peroxisome proliferator-activated nuclear receptor gamma variant 1 , peroxisome proliferator-activated receptor gamma 1 , peroxisome proliferator activator receptor, gamma , PPAR gamma 2 , xPPAR gamma , peroxisome proliferative activated receptor, gamma , peroxisome proliferator-activated receptor gamma 2 , peroxisome proliferator-activated receptor gamma 1-a , peroxisome proliferator-activated receptor gamma 1-b , PPAR gamma 1 , peroxisome proliferator activated receptor gamma-1 , peroxisome proliferator-activated receptor-gamma

443513 Ovis aries
460178 Pan troglodytes
100049014 Felis catus
100581046 Nomascus leucogenys
19016 Mus musculus
100689245 Cricetulus griseus
5468 Homo sapiens
25664 Rattus norvegicus
397769 Xenopus laevis
373928 Gallus gallus
403606 Canis lupus familiaris
397671 Sus scrofa
281993 Bos taurus
100729138 Cavia porcellus
574190 Macaca mulatta
100008892 Oryctolagus cuniculus
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