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cdk10 (show CDK10 ELISA Kits) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
Both c-Raf and B-Raf (show BRAF ELISA Kits) are required for Ras-induced MEK1 (show MAP2K1 ELISA Kits) and p42 (show EPB42 ELISA Kits) MAP kinase (show MAPK1 ELISA Kits) activation.
RhoA (show RHOA ELISA Kits)/ROCK and Raf-1/CK2 (show CSNK2A1 ELISA Kits) pathway are responsible for TNF-alpha (show TNF ELISA Kits)-mediated endothelial cytotoxicity via regulation of the vimentin (show VIM ELISA Kits) cytoskeleton.
Although Raf-1 gene is not mutated, an abnormality of Raf-1 kinase feedback regulation enhances its antiapoptotic function, and Raf-1 can still be a pharmaceutical target to increase chemotherapy or radiotherapy sensitivity in these cancer cells.
ZHX2 expression in renal cell carcinoma
RAF1 plays a critical role in maintaining the transformed phenotype of CRC cells, including those with mutated KRAS.
Zhx2 (show ZHX2 ELISA Kits) is a novel regulator of Mup expression; Zhx2 (show ZHX2 ELISA Kits) activates as well as represses expression of target genes
This finding suggests that stringent assemblage of Hsp90 (show HSP90 ELISA Kits) keeps CRAF kinase equipped for participating in the MAPK (show MAPK1 ELISA Kits) pathway. Thus, the role of Hsp90 (show HSP90 ELISA Kits) in CRAF maturation and activation acts as a limiting factor to maintain the function of a strong client like CRAF kinase.
Oncogenic NFIA:RAF1 fusion activation of the MAPK (show MAPK1 ELISA Kits) pathway is associated with pilocytic astrocytoma.
IGF2BP2 (show IGF2BP2 ELISA Kits) as a post-transcriptional regulatory mRNA-binding factor, interfering with Raf-1 degradation by miR (show MLXIP ELISA Kits)-195, that contributes to Colorectal carcinogenesis.
Data show that when microRNA miR (show MLXIP ELISA Kits)-125b was over-expressed in THP-1 (show GLI2 ELISA Kits) macrophages, the expression of Raf1 proto-oncogene (show RAB1A ELISA Kits) serine/threonine protein kinase (RAF1) was reduced to promote the apoptosis of macrophages.
Data show that Griffipavixanthone (GPX (show GPX1 ELISA Kits)), a dimeric xanthone isolated from Garcinia esculenta, is a B-RAF (show SNRPE ELISA Kits) and C-RAF inhibitor against esophageal cancer cells.
data suggest that G alpha(i3), Shc (show SHC1 ELISA Kits), Grb2 (show GRB2 ELISA Kits), Ras, and Raf-1 link Src (show SRC ELISA Kits) to activation of MAPK (show MAPK1 ELISA Kits) and to the AT(2)-dependent increase in eNOS (show NOS3 ELISA Kits) expression in PAECs
Additional Cyp (show PPIG ELISA Kits) genes are disregulated in the absence of Zhx2 (show ZHX2 ELISA Kits).
A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (show RPS6KA2 ELISA Kits) was increased in Raf1(L613V) mice. Constitutive RSK3 (show RPS6KA2 ELISA Kits) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
C-Raf involves in osteoblast survival in response to mechanical stress.
Dual inhibition of c-Raf and soluble epoxide hydrolase (show EPHX2 ELISA Kits) by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.
Simultaneous inhibition of sEH (show EPHX2 ELISA Kits) and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1 (show PDX1 ELISA Kits)-Cre mice.
under normal physiological conditions, PTEN suppresses AKT (show AKT1 ELISA Kits) activity to maintain activation of the RAF1/ERK (show EPHB2 ELISA Kits) signaling pathway, which in turn maintains normal function of the initial segment and therefore, normal sperm maturation.
these data indicate that B-RAF (show SNRPE ELISA Kits) is an important factor in oncogenic C-RAF-mediated tumorigenesis.
PHLPP (show PHLPP1 ELISA Kits) is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.
RAF proto-oncogene serine/threonine-protein kinase
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, v-raf-1 murine leukemia viral oncogene homolog 1
, proto-oncogene c-RAF
, RAF proto-oncogene serine/threonine-protein kinase-like
, Oncogene RAF1
, raf proto-oncogene serine/threonine protein kinase
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, AFP regulator 1
, alpha-fetoprotein regulator 1
, regulator of AFP
, transcription factor ZHX2
, zinc finger and homeodomain protein 2
, zinc fingers and homeoboxes protein 2
, zinc-fingers and homeoboxes 2
, alpha fetoprotein regulation 1, adult