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Rat (Rattus) HSD11B1 ELISA Kit for Sandwich ELISA - ABIN432666
Lauterburg, Escher, Dick, Ackermann, Frey: Uninephrectomy reduces 11?-hydroxysteroid dehydrogenase type 1 and type 2 concomitantly with an increase in blood pressure in rats. in The Journal of endocrinology 2012
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Rat (Rattus) HSD11B1 ELISA Kit for Sandwich ELISA - ABIN577974
Takaya, Yamanouchi, Kaneko: A calcium-deficient diet in rat dams during gestation and nursing affects hepatic 11?-hydroxysteroid dehydrogenase-1 expression in the offspring. in PLoS ONE 2014
The reduction of DHT obese homozygotic twins could be linked to its increased degradation by AKR1C2 (show AKR1C2 ELISA Kits) and HSD11B1, and increased estrogen levels could be linked to increased adiposity-related expression of aromatase (show CYP19A1 ELISA Kits) in adipose tissue.
this study shows that the phenotypic switch of adipose tissue macrophages from M2 to mixed M1/M2 phenotype occurred through differentiation of adipocytes in obese individuals, and upregulation of intracellular 11beta-HSD1 might play a role in the process
11beta-HSD-2 (show HSD11B2 ELISA Kits) plays an important role in the development of bone or osteoblast cell apoptosis, and the decreased expression of 11beta-HSD-2 (show HSD11B2 ELISA Kits) may aggravate steroid induced bone/osteoblast cell apoptosis.
11beta-HSD1 may be an important enzyme in the pathogenesis of fatty liver and visceral obesity.
In HSD11B1 gene of rs3753519-stratified analysis, carriers of the minor allele presented significantly increased BMI, fasting plasma glucose and HOMA-IR. The study provides support for plausible implication of the HSD11B1 polymorphisms in susceptibility to develop undesirable effects of glucocorticoid replacement in Addison's disease.
Increased 11beta-HSD1 expression and its reductase activity in granulosa cells are the major causes of increased cortisol concentration in the follicular fluid of PCOS with insulin (show INS ELISA Kits) resistance.
Reciprocal regulation of the glucocorticoid metabolizing enzymes, 11beta-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome.
increased cortisol and 11beta-HSD1 abundance and decreased LOX (show LOX ELISA Kits) abundance were observed in human amnion tissue after the labor-initiated spontaneous rupture of membranes
These findings indicated that 11beta-HSD1 inhibition can give a potential benefit in reducing obesity and lowering insulin (show INS ELISA Kits) resistance by modulating the insulin (show INS ELISA Kits)-signaling pathway and adipocytokine production.
Review of the role of HSD11B1 in pregnancy complications, fetal diseases, and later life morbidity.
Results describe the cloning, sequence and expression of 11beta-hydroxysteroid dehydrogenase type 1 from pig testis.
concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis
Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B1.
HSD11B1 was localized in mature adipocytes of early lactating cows, indicating that circulating glucocorticoids promote effects other than differentiation.
investigation of gene expression for 11HSD1, 11HSD2 (show HSD11B2 ELISA Kits), and glucocorticoid receptor (show NR3C1 ELISA Kits) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of 11HSD1 is developmentally regulated in maturing follicles
PGF2alpha but not PGE2 increases HSD11B1 bioactivity and protein expression by stimulating a posttranscriptional mechanism in stromal cells.
11beta-HSD1 deficiency in myeloid phagocytes promotes angiogenesis.
These data identify suppression of CXCL2 (show CXCL2 ELISA Kits) and CXCL5 (show CXCL5 ELISA Kits) chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury.
Brown adipose tissue (BAT (show BAAT ELISA Kits)) from aged 11beta-HSD1 KO mice showed elevated UCP1 (show UCP1 ELISA Kits) protein and mitochondrial content, and a favorable profile of BAT (show BAAT ELISA Kits) function.
We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad.
11beta-HSD1-deficient mice are not protected from metabolic disease or hepatosteatosis in the face of a nonalcoholic fatty liver disease-inducing diet.
11beta-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation.
these data suggest that corticosterone activation by 11beta-HSD1 in keratinocytes suppresses hapten-induced irritant dermatitis through suppression of expression of cytokines
Nr3c2 (show NR3C2 ELISA Kits) has a role in mouse skin development in a process that involves HSD11B1/HSD11B2 (show HSD11B2 ELISA Kits)
Loss of 11beta-HSD1 is associated with hepatocellular carcinoma.
These findings suggest that 11beta-HSD1 may contribute to the decline in Npas4 (show NPAS4 ELISA Kits) and Arc (show NOL3 ELISA Kits) mRNA levels associated with memory impairment during ageing
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
11-beta-hydroxysteroid dehydrogenase 1
, hydroxysteroid 11-beta dehydrogenase 1
, hydroxysteroid (11-beta) dehydrogenase 1
, corticosteroid 11-beta-dehydrogenase isozyme 1
, short chain dehydrogenase/reductase family 26C, member 1
, 11-beta-hydroxysteroid dehydrogenase type 1
, 11-beta hydroxysteroid dehydrogenase
, 11 beta-hydroxysteroid dehydrogenase type 1
, 7-alpha-hydroxycholesterol dehydrogenase
, 11beta-hydroxysteroid dehydrogenase type 1
, Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A)
, cortocosteroid 11-beta dehydrogenase
, hydroxysteroid dehydrogenase, 11 beta type 1