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A role for G143 in zebrafish 17beta-HSD (show HSD17B3 ELISA Kits) 1 (show SPAG8 ELISA Kits) and M146 and M147 in the two zebrafish paralogs prRDH (show RDH8 ELISA Kits) 1 and prRDH (show RDH8 ELISA Kits) 2, respectively, in substrate specificity.
Macronutrient intakes were associated with serum estradiol level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal Japanese women.
the effect of 17beta-HSD1 (show SPAG8 ELISA Kits) expression on breast cancer cell transcript profile in steroid-deprived condition, was investigated.
Mutation in the 17-beta-hydroxysteroid dehydrogenase gene is associated with congenital adrenal hyperplasia.
Substrate inhibition of 17beta-HSD1 (show SPAG8 ELISA Kits) in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 (show SPAG8 ELISA Kits) knockdown has been demonstrated.
10 natural products were evaluated leading to inhibition of the activity of 17beta-HSD1 (show SPAG8 ELISA Kits) at the concentration of 25 muM, and six of them inhibit the activity over 50%.
The structure of human 17beta-HSD1 (show SPAG8 ELISA Kits) and biological function have been studied extensively in the last two decades. In humans, the enzyme is expressed in placenta, ovary, endometrium and breast; high activity of estrogen activation provides the basis of 17beta-HSD1 (show SPAG8 ELISA Kits)'s implication in estrogen-dependent diseases, such as breast cancer, endometriosis and non-small cell lung carcinomas. [Review]
These findings suggested that the HSD17B1 Ser312Gly polymorphism might confer genetic cancer susceptibility in an ethnic-dependent manner, especially among Caucasians.
The rs605059 polymorphism of the HSD17B1 gene is associated with increased risk of recurrent spontaneous abortion.
Review/Meta-analysis: HSD17B1 rs605059 polymorphisms were not associated with the risks of endometrial cancer or endometriosis.
the HSD17B1 transcript and protein were identified in HeLa, SiHa, Ca Ski (show SKI ELISA Kits) and C-33A cervical cancer cells.
HSD17B1 gene was significantly associated with litter size in two populations and could be a useful molecular marker in selection for increasing litter size in pigs.
This study indicates that HSD17B1 is a key enzyme in ovarian steroidogenesis and has a novel function in initiation and stabilization of pregnancy
cellular localization of 17beta-HSD mRNA type 1 expression in the ovary, testis, skin, prostate and pituitary gland
17beta-HSD tissue distribution was studied in inbred C57BL mice of both sexes.
Androgens and estrogens are formed via the action of type 5 17beta-HSD in specific cell types in the liver, ovary, adrenal cortex, and kidney.
Activin A (show INHBA ELISA Kits) rapidly regulates Hsd17b1 transcription in gonadotrope and granulosa cells and may thereby regulate local 17beta-estradiol synthesis.
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
17beta-hydroxysteroid dehydrogenase type 1
, estradiol 17-beta-dehydrogenase 1
, 17-beta-hydroxysteroid dehydrogenase type 1
, 17-beta hydroxysteroid dehydrogenase
, zf 1.2
, 17-beta-HSD 1
, 20 alpha-hydroxysteroid dehydrogenase
, estradiol 17-beta-dehydrogenase-1
, hydroxysteroid (17-beta) dehydrogenase 1 isoform
, placental 17-beta-hydroxysteroid dehydrogenase
, short chain dehydrogenase/reductase family 28CE, member 1
, 17-beta-dehydrogenase 1
, Hydroxysteroid dehydrogenase 17 beta, type 1