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HSD17B1 is a promising marker to predict EC prognosis.
Macronutrient intakes were associated with serum estradiol level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal Japanese women.
the effect of 17beta-HSD1 (show SPAG8 Proteins) expression on breast cancer cell transcript profile in steroid-deprived condition, was investigated.
Mutation in the 17-beta-hydroxysteroid dehydrogenase gene is associated with congenital adrenal hyperplasia.
Substrate inhibition of 17beta-HSD1 (show SPAG8 Proteins) in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 (show SPAG8 Proteins) knockdown has been demonstrated.
10 natural products were evaluated leading to inhibition of the activity of 17beta-HSD1 (show SPAG8 Proteins) at the concentration of 25 muM, and six of them inhibit the activity over 50%.
The structure of human 17beta-HSD1 (show SPAG8 Proteins) and biological function have been studied extensively in the last two decades. In humans, the enzyme is expressed in placenta, ovary, endometrium and breast; high activity of estrogen activation provides the basis of 17beta-HSD1 (show SPAG8 Proteins)'s implication in estrogen-dependent diseases, such as breast cancer, endometriosis and non-small cell lung carcinomas. [Review]
These findings suggested that the HSD17B1 Ser312Gly polymorphism might confer genetic cancer susceptibility in an ethnic-dependent manner, especially among Caucasians.
The rs605059 polymorphism of the HSD17B1 gene is associated with increased risk of recurrent spontaneous abortion.
Review/Meta-analysis: HSD17B1 rs605059 polymorphisms were not associated with the risks of endometrial cancer or endometriosis.
This study indicates that HSD17B1 is a key enzyme in ovarian steroidogenesis and has a novel function in initiation and stabilization of pregnancy
cellular localization of 17beta-HSD mRNA type 1 expression in the ovary, testis, skin, prostate and pituitary gland
17beta-HSD tissue distribution was studied in inbred C57BL mice of both sexes.
Androgens and estrogens are formed via the action of type 5 17beta-HSD in specific cell types in the liver, ovary, adrenal cortex, and kidney.
Activin A (show INHBA Proteins) rapidly regulates Hsd17b1 transcription in gonadotrope and granulosa cells and may thereby regulate local 17beta-estradiol synthesis.
A role for G143 in zebrafish 17beta-HSD 1 and M146 and M147 in the two zebrafish paralogs prRDH 1 and prRDH 2, respectively, in substrate specificity.
HSD17B1 gene was significantly associated with litter size in two populations and could be a useful molecular marker in selection for increasing litter size in pigs.
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
, 17-beta-hydroxysteroid dehydrogenase type 1
, 20 alpha-hydroxysteroid dehydrogenase
, estradiol 17-beta-dehydrogenase 1
, estradiol 17-beta-dehydrogenase-1
, hydroxysteroid (17-beta) dehydrogenase 1 isoform
, placental 17-beta-hydroxysteroid dehydrogenase
, short chain dehydrogenase/reductase family 28CE, member 1
, Hydroxysteroid dehydrogenase 17 beta, type 1
, 17-beta hydroxysteroid dehydrogenase
, zf 1.2
, 17-beta-dehydrogenase 1
, 17beta-hydroxysteroid dehydrogenase type 1