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Browse our HSD17B1 Proteins (HSD17B1)

Full name:
Hydroxysteroid (17-Beta) Dehydrogenase 1 Proteins (HSD17B1)
On are 8 Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) Proteins from 5 different suppliers available. Additionally we are shipping HSD17B1 Antibodies (64) and HSD17B1 Kits (5) and many more products for this protein. A total of 79 HSD17B1 products are currently listed.
17beta-HSD, 17BHD1, 17HSDB1, E2DH, EDH17B2, EDHB17, HSD17, Hsd17ba, SDR28C1, zfHSD17B1
list all proteins Gene Name GeneID UniProt
HSD17B1 3292 P14061
HSD17B1 15485 P51656
HSD17B1 25322 P51657

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HSD17B1 Proteins (HSD17B1) by Origin

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Horse (Equine) Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) interaction partners

Zebrafish Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) interaction partners

  1. A role for G143 in zebrafish 17beta-HSD 1 and M146 and M147 in the two zebrafish paralogs prRDH 1 and prRDH 2, respectively, in substrate specificity.

Human Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) interaction partners

  1. 10 natural products were evaluated leading to inhibition of the activity of 17beta-HSD1 (show SPAG8 Proteins) at the concentration of 25 muM, and six of them inhibit the activity over 50%.

  2. The structure of human 17beta-HSD1 (show SPAG8 Proteins) and biological function have been studied extensively in the last two decades. In humans, the enzyme is expressed in placenta, ovary, endometrium and breast; high activity of estrogen activation provides the basis of 17beta-HSD1 (show SPAG8 Proteins)'s implication in estrogen-dependent diseases, such as breast cancer, endometriosis and non-small cell lung carcinomas. [Review]

  3. These findings suggested that the HSD17B1 Ser312Gly polymorphism might confer genetic cancer susceptibility in an ethnic-dependent manner, especially among Caucasians.

  4. The rs605059 polymorphism of the HSD17B1 gene is associated with increased risk of recurrent spontaneous abortion.

  5. Review/Meta-analysis: HSD17B1 rs605059 polymorphisms were not associated with the risks of endometrial cancer or endometriosis.

  6. the HSD17B1 transcript and protein were identified in HeLa, SiHa, Ca Ski (show SKI Proteins) and C-33A cervical cancer cells.

  7. Increased expression of HSD17B1 in NSCLC may contribute to an elevated intratissue level of E2 and consequently may support the development and spread of cancer.

  8. The key enzymes of ovarian steroidogenesis, CYP 19 (show CYP19A1 Proteins) and 17beta-HSD (show HSD17B3 Proteins), are active in the ovaries of postmenopausal women.

  9. 17beta-HSD1 (show SPAG8 Proteins) and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells.

  10. E1-induced ERELuc activity in the inhibitor-treated uterus was reduced by the HSD17B1 inhibitor.

Pig (Porcine) Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) interaction partners

  1. HSD17B1 gene was significantly associated with litter size in two populations and could be a useful molecular marker in selection for increasing litter size in pigs.

Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) interaction partners

  1. This study indicates that HSD17B1 is a key enzyme in ovarian steroidogenesis and has a novel function in initiation and stabilization of pregnancy

  2. cellular localization of 17beta-HSD mRNA type 1 expression in the ovary, testis, skin, prostate and pituitary gland

  3. 17beta-HSD tissue distribution was studied in inbred C57BL mice of both sexes.

  4. Androgens and estrogens are formed via the action of type 5 17beta-HSD in specific cell types in the liver, ovary, adrenal cortex, and kidney.

  5. Activin A (show INHBA Proteins) rapidly regulates Hsd17b1 transcription in gonadotrope and granulosa cells and may thereby regulate local 17beta-estradiol synthesis.

HSD17B1 Protein Profile

Protein Summary

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Alternative names and synonyms associated with HSD17B1

  • hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1)
  • hydroxysteroid (17-beta) dehydrogenase 1 (hsd17b1)
  • hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1)
  • hydroxysteroid (17-beta) dehydrogenase 1-like (HSD17B1)
  • 17beta-HSD protein
  • 17BHD1 protein
  • 17HSDB1 protein
  • E2DH protein
  • EDH17B2 protein
  • EDHB17 protein
  • HSD17 protein
  • Hsd17ba protein
  • SDR28C1 protein
  • zfHSD17B1 protein

Protein level used designations for HSD17B1

17beta-hydroxysteroid dehydrogenase type 1 , estradiol 17-beta-dehydrogenase 1 , 17-beta-hydroxysteroid dehydrogenase type 1 , 17-beta hydroxysteroid dehydrogenase , zf 1.2 , 17-beta-HSD 1 , 20 alpha-hydroxysteroid dehydrogenase , 20-alpha-HSD , E2DH , estradiol 17-beta-dehydrogenase-1 , hydroxysteroid (17-beta) dehydrogenase 1 isoform , placental 17-beta-hydroxysteroid dehydrogenase , short chain dehydrogenase/reductase family 28CE, member 1 , 17-beta-dehydrogenase 1 , Hydroxysteroid dehydrogenase 17 beta, type 1

100036556 Equus caballus
353107 Bos taurus
402842 Danio rerio
710392 Macaca mulatta
3292 Homo sapiens
607570 Canis lupus familiaris
100147712 Sus scrofa
15485 Mus musculus
25322 Rattus norvegicus
454689 Pan troglodytes
785989 Bos taurus
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