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High 4-tert (show TERT ELISA Kits)-Octylphenol doses affect the cytoarchitecture of MA-10 Leydig cells as well as attenuate 3beta-HSD (show HAL ELISA Kits) and AR expression.
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc (show CYP11A1 ELISA Kits), P450 (show POR ELISA Kits)(17alpha) and 17beta-HSD (show HSD17B1 ELISA Kits) in mice.
analysis of Tunisian patients with mutations in the gene encoding 17beta-hydroxysteroid dehydrogenase (show HSD17B7 ELISA Kits) type 3 and a founder effect
Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH.
Mutations in the HSD17B3 gene is associated with Disorders of Sex Development.
Expression of the genes HSD3B1 (show HSD3B1 ELISA Kits), HSD17B3, and SRD5A2 (show SRD5A2 ELISA Kits) was significantly increased in BPH (show GLI3 ELISA Kits) tissues compared to normal adjacent prostate tissues.
Missense mutation in HSD17B3 gene in a 46, XY adolescent is associated with primary amenorrhea and virilization at puberty
38% of unrelated 46,XY females with unknown diagnosis in the study have HSD17B3 mutations predicted to cause HSD17B3 deficiency.
These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias.
68 males with testicular 17beta-HSD deficiency were identified among a highly inbred Arab population in Israel as affected with male pseudohermaphroditism. [Review]
The H8 haplotype of the HSD17B3 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China.
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
17(beta)HSD type 3
, 17-beta-HSD 3
, 17-beta-hydroxysteroid dehydrogenase type 3
, testicular 17-beta-hydroxysteroid dehydrogenase
, testosterone 17-beta-dehydrogenase 3
, estradiol 17 beta-dehydrogenase 3
, short chain dehydrogenase/reductase family 12C, member 2