Browse our SRD5A1 Proteins (SRD5A1)

On are 3 Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1) Proteins from 2 different suppliers available. Additionally we are shipping SRD5A1 Antibodies (55) and SRD5A1 Kits (24) and many more products for this protein. A total of 89 SRD5A1 products are currently listed.
0610031P22Rik, 4930435F02Rik, S5AR 1, Srd5a-1, zgc:153768
list all proteins Gene Name GeneID UniProt
SRD5A1 78925 Q68FF9
SRD5A1 6715 P18405
Rat SRD5A1 SRD5A1 24950 P24008

SRD5A1 Proteins (SRD5A1) by Origin

More Proteins for SRD5A1 Interaction Partners

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1) interaction partners

  1. Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (show AR Proteins) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (show DPT Proteins) mice

  2. the Srd5a1 gene modulates ethanol consumption in a sex-dependent manner that is also contingent upon ethanol access condition and concentration

  3. deletion of the Srd5a1 gene significantly decreased ethanol's anxiolytic effect in female mice, and chronic ethanol withdrawal severity was lower in female versus male mice

  4. transcription of srd5a1 in brain is regulated by environmental factor-induced cytosine methylation in the promoter region.

  5. The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin (show INS Proteins) resistance in male rats and mice are reported.

  6. Thus, 5alpha-reductase may be required for the estrous cycle variations in affective behavior and 3alpha,5alpha-THP (show UMOD Proteins) levels of female mice.

  7. results suggest that local steroid 5 alpha-reductase 1 messenger RNA expression in Withdrawal Seizure-Prone mouse brain may not change in parallel with local allopregnanolone content or withdrawal severity

  8. The aim of the present study was to investigate the role of 5alpha-reductase type 1 for bone mass using Srd5a1-/- mice.

  9. This study evaluates 5alpha-R type I and 3alpha-HSD (show DHRS9 Proteins) mRNA expression level in mouse brain by using in situ hybridization.

  10. Data suggests that in male mice after social isolation, expression of Srd5a1 mRNA is specifically down-regulated in glutamatergic pyramidal neurons. In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders.

Human Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1) interaction partners

  1. Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (show INS Proteins) resistance (IR) rather than obesity.

  2. Although 4-dione is the main source of 5alpha-dihydrotestosterone in human preadipocytes, production of this steroid by 5 alpha-reductase isoenzymes (SRD5A1, 2 and 3) mediates the inhibitory effect of both 4-dione and testosterone on preadipocyte differentiation.

  3. SRD5A1 small-interfering RNA knockdown led to significant increase in progesterone receptor (show PGR Proteins)-B nuclear import, ectopic, whereas SRD5A1 overexpression resulted in remarkable inhibition of nuclear progesterone receptor (show PGR Proteins)-B in P4-treated cells. Repression of SRD5A1 activated progesterone receptor (show PGR Proteins)-B responsive gene, whereas overexpression of SRD5A1 possessed an inhibitory effect.

  4. the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 and SRD5A2 (show SRD5A2 Proteins) in a set of Spanish prostate cancer patients, were evaluated.

  5. A total of 2 SNPs in SRD5A1-rs3822430 and rs1691053-were associated with prostate-specific antigen (show KLK3 PLURAL_@39934@) level at diagnosis.

  6. In model cell lines of endometrial cancer, AKR1C2 (show AKR1C2 Proteins) and SRD5A1 have crucial roles in progesterone metabolism.

  7. SRD5A1 rs166050C risk variant was associated with greater prostatic exposure to androsterone

  8. Significantly higher levels of SRD5A1, AKR1C2 (show AKR1C2 Proteins), AKR1C3 (show AKR1C3 Proteins), and HSD17B10 (show HSD17B10 Proteins) mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue

  9. SRD5A1 and SRD5A2 (show SRD5A2 Proteins) single nucleotide polymorphisms are significantly associated with the clinical characteristics of benign prostatic hyperplasia and the efficacy of benign prostatic hyperplasia treatment.

  10. Different effects were seen for progesterone, which significantly decreased SRD5A1 protein levels.

SRD5A1 Protein Profile

Protein Summary

Steroid 5-alpha-reductase (EC catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).

Alternative names and synonyms associated with SRD5A1

  • steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (SRD5A1)
  • steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (srd5a1)
  • 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Bm1_06570)
  • 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CC1G_14953)
  • steroid 5 alpha-reductase 1 (Srd5a1)
  • steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (Srd5a1)
  • 0610031P22Rik protein
  • 4930435F02Rik protein
  • S5AR 1 protein
  • Srd5a-1 protein
  • zgc:153768 protein

Protein level used designations for SRD5A1

steroid-5-alpha-reductase 1 , 3-oxo-5-alpha-steroid 4-dehydrogenase 1 , SR type 1 , steroid 5-alpha-reductase 1 , type 1 5alpha-reductase , 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1 , 5-alpha reductase , steroid 5-alpha-reductase type I , steroid 5 alpha-reductase 1 , prostatic steroid 5-alpha-reductase type I , 3-oxo-5-alpha-steroid 4-dehydrogenase 1-like

743740 Pan troglodytes
767715 Danio rerio
6096243 Brugia malayi
9378132 Coprinopsis cinerea okayama7130
78925 Mus musculus
6715 Homo sapiens
24950 Rattus norvegicus
403716 Canis lupus familiaris
614612 Bos taurus
770453 Gallus gallus
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