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Browse our ROCK2 Proteins (ROCK2)

Full name:
rho-Associated, Coiled-Coil Containing Protein Kinase 2 Proteins (ROCK2)
On www.antibodies-online.com are 8 rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) Proteins from 6 different suppliers available. Additionally we are shipping ROCK2 Antibodies (155) and ROCK2 Kits (19) and many more products for this protein. A total of 190 ROCK2 products are currently listed.
Synonyms:
B230113H15Rik, mKIAA0619, Rho-kinase, ROCK-II, ROCK2, Rock2m, rocka-a, ROK, rok2, ROKalpha, xROK
list all proteins Gene Name GeneID UniProt
ROCK2 19878 P70336
ROCK2 25537 Q62868
ROCK2 9475 O75116

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ROCK2 Proteins (ROCK2) by Origin

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More Proteins for ROCK2 Interaction Partners

Xenopus laevis rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.

  2. Data demonstrate a direct relationship between SHP-2(N308D) and ROCK activation in the developing heart.

  3. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.

Zebrafish rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Data show that Rock2 acts as a negative regulator of the TGFbeta (show TGFB1 Proteins) signaling pathway.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Inhibition of the RhoA (show RHOA Proteins)/Rock2 kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins) in the mouse spinal cord.

  2. found that cigarette smoke leads to decreased ROCK2 activation and IRF4 (show IRF4 Proteins) phosphorylation in T cells

  3. Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

  4. Results suggest that Rho-associated, coiled-coil containing protein kinase (ROCK) inhibitors fasudil may be an emerging therapeutic option for targeting cancer vasculogenic mimicry (VM).

  5. Lin28a (show LIN28A Proteins) protects against DCM through PKA/ROCK2 dependent pathway.

  6. ROCK2 is pivotal to baseline junctional tension as a novel mechanism by which Rho kinase primes the endothelium for hyperpermeability responses.

  7. ROCK1 (show ROCK1 Proteins)-dependent changes in hyaluronan may contribute to ROCK1 (show ROCK1 Proteins)'s role in O3-induced AHR (show AHR Proteins), the role of ROCK2 is downstream of inflammation, likely at the level of airway smooth muscle contraction.

  8. increased activation of ROCK2 contributes to obesity-induced cardiac dysfunction and insulin (show INS Proteins) resistance and that inhibition of ROCK2 may constitute a novel approach to treat this condition.

  9. Ischemia/reperfusion injury activates ROCK2, preventing axonal growth. ROCK inhibitor, fasudil hydrochloride, promotes axonal growth.

  10. Noise-decreased levels of ROCK2 results in reduction of phosphorylation of ERM that leads to depolymerization of actin filaments.

Human rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Uniaxial stretch activates JNK1 (show MAPK8 Proteins) via RhoA (show RHOA Proteins) and ROCK pathways in human bladder smooth muscle cells.

  2. Data clearly suggests association of ROCK2 polymorphisms and haplotypes with high altitude essential hypertension in a Ladakhi Indian population.

  3. 17beta-estradiol induces proliferation of uterine smooth muscle cells in endometriosis through hyperactivation of the estrogen receptor (show ESR1 Proteins)-RhoA (show RHOA Proteins)/ROCK signaling pathway.

  4. no differences in renal interstitial fibrosis or UUOinduced ROCK activity were identified between the ROCK2 heterozygote knockout and WT mice, indicating that the genetic partial disruption of ROCK2 is insufficient for protecting against renal fibrosis.

  5. Study shows that nuclear ROCKII activation signal might contribute to the tumor metastasis in breast cancer.

  6. This is the first study to examine the involvement of ROCK1 (show ROCK1 Proteins) and ROCK2 gene variations in the risk of primary open-angle glaucoma development.

  7. Rho Kinase ROCK2 Mediates Acid-Induced NADPH Oxidase (show NOX1 Proteins) NOX5 (show NOX5 Proteins)-S Expression in Human Esophageal Adenocarcinoma Cells

  8. ROCK2 forms a dimer, 120 nm in length, with a long coiled-coil tether linking the kinase and membrane-binding domains.

  9. We speculate that the drop of the ROCK-to-MLCK (show MYLK Proteins) ratio may occur as an attempt to compensate for the increased Rho kinase (show ROCK1 Proteins) activity.

  10. This study report that protein levels of the Rho-associated protein kinases (ROCK2) was increased in Progressive Supranuclear Palsy and Corticobasal Degeneration brains.

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Results indicate that ROCK1 (show ROCK1 Proteins) and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha.

  3. It is highly possible that Rho-kinase (show ROCK1 Proteins) plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase (show ROCK1 Proteins) is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Rho-kinase (show ROCK1 Proteins) analysis of coiled-coil association of the RhoA (show RHOA Proteins)-binding domain

  2. RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.

  3. nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity

ROCK2 Protein Profile

Protein Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

Alternative names and synonyms associated with ROCK2

  • Rho-associated, coiled-coil containing protein kinase 2 (rock2)
  • rho-associated, coiled-coil containing protein kinase 2a (rock2a)
  • Rho-associated, coiled-coil containing protein kinase 2 (ROCK2)
  • Rho-associated coiled-coil containing protein kinase 2 (Rock2)
  • Rho-associated coiled-coil containing protein kinase 2-like (LOC100346837)
  • Rho-associated, coiled-coil containing protein kinase 2 (Rock2)
  • B230113H15Rik protein
  • mKIAA0619 protein
  • Rho-kinase protein
  • ROCK-II protein
  • ROCK2 protein
  • Rock2m protein
  • rocka-a protein
  • ROK protein
  • rok2 protein
  • ROKalpha protein
  • xROK protein

Protein level used designations for ROCK2

Rho-associated kinase alpha , rho-associated protein kinase 2 , rho-associated, coiled-coil containing protein kinase 2 , Rho-associated, coiled-coil containing protein kinase 2 , rho-associated protein kinase 2-like , Rho-associated coiled-coil forming kinage 2 , p164 ROCK-2 , rho-associated, coiled-coil-containing protein kinase 2 , rho-associated, coiled-coil-containing protein kinase II , ROKalpha , Rho-associated coiled-coil forming kinase 2 , RhoA - binding serine/threosine kinase alpha (ROK - alpha) , p150 ROK-alpha , rhoA-binding kinase 2 , Rho-kinase alpha

GENE ID SPECIES
394289 Xenopus laevis
317747 Danio rerio
470307 Pan troglodytes
708444 Macaca mulatta
100221127 Taeniopygia guttata
100294663 Ovis aries
100461801 Pongo abelii
100578506 Apis mellifera
100585294 Nomascus leucogenys
19878 Mus musculus
25537 Rattus norvegicus
100346837 Oryctolagus cuniculus
9475 Homo sapiens
374182 Gallus gallus
482970 Canis lupus familiaris
397445 Sus scrofa
282041 Bos taurus
100713798 Cavia porcellus
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