Browse our ROCK2 Proteins (ROCK2)

Full name:
rho-Associated, Coiled-Coil Containing Protein Kinase 2 Proteins (ROCK2)
On are 12 rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) Proteins from 7 different suppliers available. Additionally we are shipping ROCK2 Antibodies (172) and ROCK2 Kits (25) and many more products for this protein. A total of 218 ROCK2 products are currently listed.
B230113H15Rik, mKIAA0619, Rho-kinase, ROCK-II, ROCK2, Rock2m, rocka-a, ROK, rok2, ROKalpha, xROK
list all proteins Gene Name GeneID UniProt
ROCK2 19878 P70336
ROCK2 25537 Q62868
ROCK2 9475 O75116

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ROCK2 Proteins (ROCK2) by Origin

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More Proteins for ROCK2 Interaction Partners

Xenopus laevis rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.

  2. Data demonstrate a direct relationship between SHP-2(N308D) and ROCK activation in the developing heart.

  3. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.

Zebrafish rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. The findings of the present study indicate that miR (show MYLIP Proteins)-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a.

  2. Data show that Rock2 acts as a negative regulator of the TGFbeta (show TGFB1 Proteins) signaling pathway.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Results strongly support the hypothesis that spinal RhoA (show RHOA Proteins)/ROCK2 signaling plays a central role in the neuropathic pain. In addition, simvastatin might exert its antihyperalgesic and antiallodynic effects through the attenuation of sensitization of spinal nociceptive transmission that is modulated by mechanisms dependent on the RhoA (show RHOA Proteins)/ROCK2 signaling.

  2. p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2/NF-kappaB (show NFKB1 Proteins) signalling in skin carcinogenesis.these data show that ROCK2 activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (show TP53 Proteins) loss and novel NF-kappaB (show NFKB1 Proteins) expression

  3. The effect of Smad4 (show SMAD4 Proteins) was at least partially mediated by the downstream effectors Syk (show SYK Proteins) and ROCK2 transcription in megakaryocytes.

  4. Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (show ESR1 Proteins) (ROCK2:ER). This two-stage system of regulation allows for tissue-selective expression of the ROCK2:ER fusion protein, which then requires administration of estrogen analogues

  5. The results of the present study verify that ROCKII participates in the loss of DA neurons induced by MPTP (show PTPN2 Proteins) and suggest that ROCKII inhibition may be a promising therapeutic target for PD.

  6. These results indicate that tensile force induces in vivo gene expression associated with vascularization early in tensile-force-induced sutural bone formation. Moreover, the early induction of Vegf (show VEGFA Proteins) gene expression is regulated by CTGF (show CTGF Proteins) and ROCK2.

  7. While the loss of either Rock1 (show ROCK1 Proteins) or Rock2 had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 (show ROCK1 Proteins) and Rock2 have been genetically deleted.

  8. In experimental autoimmune encephalomyelitis (EAE), ROCK activity was also increased in serum, spleen, brain and spinal cord. Neuron injury with scratch and TNF-alpha (show TNF Proteins) stimulation induced the up-regulation of ROCK activity.

  9. Inhibition of the RhoA (show RHOA Proteins)/Rock2 kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins) in the mouse spinal cord.

  10. found that cigarette smoke leads to decreased ROCK2 activation and IRF4 (show IRF4 Proteins) phosphorylation in T cells

Human rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Despite sharing the catalytic domain with ROCK2, ROCK1 (show ROCK1 Proteins) appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.

  2. Studies showed that ROCK isoforms, ROCK1 (show ROCK1 Proteins) and ROCK2, have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]

  3. ICAP-1 (show ITGB1BP1 Proteins) monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility.

  4. BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.

  5. this study shows that ulinastatin (show AMBP Proteins) inhibites the hyperpermeability of vascular endothelial cells induced by TNF-alpha (show TNF Proteins), and that this inhibitory effect may be related to the RhoA (show RHOA Proteins)/ROCK2 signaling pathway

  6. Taken together, these results suggest that this newly identified Rock2-beta-catenin (show CTNNB1 Proteins)/TCF4 (show TCF4 Proteins)-SCARA5 (show SCARA5 Proteins) axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC (show XRCC1 Proteins).

  7. Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1 (show NEUROG1 Proteins), RhoA (show RHOA Proteins), and ROCK2.

  8. The positive rates of Rock2 protein in normal esophageal epithelium tissue was 12.3% and in esophageal carcinomas tissues was 56.5%. The expression of Rock2 protein was related with vascular invasion and there was no significant difference between the expression of Rock2 protein and ESCC patients' tumor location, differentiation, T stage, and lymph node metastases.

  9. There are 2 isoforms: ROCK1 (show ROCK1 Proteins) and ROCK2. They have different functions in different types of cells and tissues. There is growing evidence that ROCKs contribute to the development of cardiovascular diseases, including cardiac fibrosis, hypertrophy, and subsequent heart failure.

  10. a soft extracellular matrix causes downregulation of ROCK2 expression, which drives resistance to chemotherapy by repressing p53 (show TP53 Proteins) activation.

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Results indicate that ROCK1 (show ROCK1 Proteins) and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha.

  3. It is highly possible that Rho-kinase (show ROCK1 Proteins) plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase (show ROCK1 Proteins) is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Rho-kinase (show ROCK1 Proteins) analysis of coiled-coil association of the RhoA (show RHOA Proteins)-binding domain

  2. RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.

  3. nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity

ROCK2 Protein Profile

Protein Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

Alternative names and synonyms associated with ROCK2

  • Rho-associated, coiled-coil containing protein kinase 2 (rock2)
  • rho-associated, coiled-coil containing protein kinase 2a (rock2a)
  • Rho-associated, coiled-coil containing protein kinase 2 (ROCK2)
  • Rho-associated coiled-coil containing protein kinase 2 (Rock2)
  • Rho-associated coiled-coil containing protein kinase 2-like (LOC100346837)
  • Rho-associated, coiled-coil containing protein kinase 2 (Rock2)
  • B230113H15Rik protein
  • mKIAA0619 protein
  • Rho-kinase protein
  • ROCK-II protein
  • ROCK2 protein
  • Rock2m protein
  • rocka-a protein
  • ROK protein
  • rok2 protein
  • ROKalpha protein
  • xROK protein

Protein level used designations for ROCK2

Rho-associated kinase alpha , rho-associated protein kinase 2 , rho-associated, coiled-coil containing protein kinase 2 , Rho-associated, coiled-coil containing protein kinase 2 , rho-associated protein kinase 2-like , Rho-associated coiled-coil forming kinage 2 , p164 ROCK-2 , rho-associated, coiled-coil-containing protein kinase 2 , rho-associated, coiled-coil-containing protein kinase II , ROKalpha , Rho-associated coiled-coil forming kinase 2 , RhoA - binding serine/threosine kinase alpha (ROK - alpha) , p150 ROK-alpha , rhoA-binding kinase 2 , Rho-kinase alpha

394289 Xenopus laevis
317747 Danio rerio
470307 Pan troglodytes
708444 Macaca mulatta
100221127 Taeniopygia guttata
100294663 Ovis aries
100461801 Pongo abelii
100578506 Apis mellifera
100585294 Nomascus leucogenys
19878 Mus musculus
25537 Rattus norvegicus
100346837 Oryctolagus cuniculus
9475 Homo sapiens
374182 Gallus gallus
482970 Canis lupus familiaris
397445 Sus scrofa
282041 Bos taurus
100713798 Cavia porcellus
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