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Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
Data demonstrate a direct relationship between SHP-2(N308D) and ROCK activation in the developing heart.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
The findings of the present study indicate that miR (show MYLIP Proteins)-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a.
Data show that Rock2 acts as a negative regulator of the TGFbeta (show TGFB1 Proteins) signaling pathway.
ROCK2 contributes to allergic airways responses likely via effects within ASM (show SMPD1 Proteins) cells and within non-lymphocyte cells involved in lymphocyte activation and migration into the airways.
BRAF (show BRAF Proteins) and ROKalpha form independent RAF1 (show RAF1 Proteins) complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (show EGF Proteins)).
Dexamethasone up-regulates ROCK1 (show ROCK1 Proteins)/2 activity promoting migration, invasion and metastasis of melanoma cells.
these data suggest that ROCK2 signaling plays a critical role in controlling the development of TFH cells induced by autoimmune conditions through reciprocal regulation of STAT3 (show STAT3 Proteins) and STAT5 (show STAT5A Proteins) activation.
Data indicate that oxidative stress in diabetes causes a decrease in miR (show MLXIP Proteins)-133a expression leading to an increase in RhoA (show RHOA Proteins)/Rho kinase pathway and muscle contraction.
Results strongly support the hypothesis that spinal RhoA (show RHOA Proteins)/ROCK2 signaling plays a central role in the neuropathic pain. In addition, simvastatin might exert its antihyperalgesic and antiallodynic effects through the attenuation of sensitization of spinal nociceptive transmission that is modulated by mechanisms dependent on the RhoA (show RHOA Proteins)/ROCK2 signaling.
p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2/NF-kappaB (show NFKB1 Proteins) signalling in skin carcinogenesis.these data show that ROCK2 activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (show TP53 Proteins) loss and novel NF-kappaB (show NFKB1 Proteins) expression
The effect of Smad4 (show SMAD4 Proteins) was at least partially mediated by the downstream effectors Syk (show SYK Proteins) and ROCK2 transcription in megakaryocytes.
Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (show ESR1 Proteins) (ROCK2:ER). This two-stage system of regulation allows for tissue-selective expression of the ROCK2:ER fusion protein, which then requires administration of estrogen analogues
The results of the present study verify that ROCKII participates in the loss of DA neurons induced by MPTP (show PTPN2 Proteins) and suggest that ROCKII inhibition may be a promising therapeutic target for PD.
Data indicate that the ROCKII inhibitor H1152 increases insulin (show INS Proteins) secreting cells from hPSCs and improves beta-cell maturation on transplantation in vivo.
Results showed that ROCK1 (show ROCK1 Proteins) gene rs2271255 (Lys222Glu), rs35996865, and ROCK2 gene rs726843, rs2290156, rs10178332, rs35768389 (Asp601Val) polymorphisms were significantly associated with respiratory distress syndrome (RDS (show PRPH2 Proteins)), and that they could be a risk factor for development of neonatal RDS (show PRPH2 Proteins).
Despite sharing the catalytic domain with ROCK2, ROCK1 (show ROCK1 Proteins) appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.
Studies showed that ROCK isoforms, ROCK1 (show ROCK1 Proteins) and ROCK2, have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]
ICAP-1 (show ITGB1BP1 Proteins) monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility.
BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.
this study shows that ulinastatin (show AMBP Proteins) inhibites the hyperpermeability of vascular endothelial cells induced by TNF-alpha (show TNF Proteins), and that this inhibitory effect may be related to the RhoA (show RHOA Proteins)/ROCK2 signaling pathway
Taken together, these results suggest that this newly identified Rock2-beta-catenin (show CTNNB1 Proteins)/TCF4 (show TCF4 Proteins)-SCARA5 (show SCARA5 Proteins) axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC (show XRCC1 Proteins).
Results indicate that ROCK1 (show ROCK1 Proteins) and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha.
It is highly possible that Rho-kinase (show ROCK1 Proteins) plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase (show ROCK1 Proteins) is not involved in endothelial regeneration after vascular injury.
Rho-kinase (show ROCK1 Proteins) analysis of coiled-coil association of the RhoA (show RHOA Proteins)-binding domain
RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.
nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Rho-associated kinase alpha
, rho-associated protein kinase 2
, rho-associated, coiled-coil containing protein kinase 2
, Rho-associated, coiled-coil containing protein kinase 2
, rho-associated protein kinase 2-like
, Rho-associated coiled-coil forming kinage 2
, p164 ROCK-2
, rho-associated, coiled-coil-containing protein kinase 2
, rho-associated, coiled-coil-containing protein kinase II
, Rho-associated coiled-coil forming kinase 2
, RhoA - binding serine/threosine kinase alpha (ROK - alpha)
, p150 ROK-alpha
, rhoA-binding kinase 2
, Rho-kinase alpha