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Knockdown of vps4b in zebrafish recapitulated the reduction of tooth size.
Our findings support a role for VPS4B in MM cell proliferation, adhesion, and drug resistance, and pave the way for a novel therapeutic approach targeting this molecule.
Lack of ALG-2 (show PDCD6 Proteins), ALIX (show PDCD6IP Proteins) or Vps4B each prevents shedding, and repair of the injured cell membrane
Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5.
ESCRT-III protein CHMP5 inhibits LIP5-mediated VPS4 activation by inducing a moderate conformational change within LIP5.
High Vacuolar protein sorting 4B results in more apoptosis of intestinal epithelial cells via p38 MAPK (show MAPK14 Proteins) in Crohn's disease.
Taken together, it was concluded that VPS4B and its DN mutant VPS4B-K180Q have anti-HBV effect in vivo, which helps develop molecular therapeutic strategies for HBV infection.
Protein kinase CK2 (show CSNK2A1 Proteins) alpha (show CSNK2A2 Proteins) is involved in the phosphorylation of the ESCRT-III subunits CHMP3 (show CHMP3 Proteins) and CHMP2B (show CHMP2B Proteins), as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly.
VPS4B may promote the progression of Carcinoma, Non-Small-Cell Lung (NSCLC) and be a biotarget for NSCLCs therapy.
An inverse correlation between VPS4B expression and EGFR (show EGFR Proteins) abundance is observed in breast tumors, and high-grade or recurrent breast carcinomas exhibit lower VPS4B expression.
ATP hydrolysis would eliminate this interaction and subsequent nucleotide release causes the domains to rotate, which together lead to the disassembly of the SKD1 oligomer
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18\; the gene for the other resides on chromosome 16.
vacuolar protein sorting-associated protein 4B
, vacuolar protein sorting 4b
, vacuolar protein sorting 4B
, vacuolar protein sorting 4a
, vacuolar protein sorting 4 homolog B (S. cerevisiae)
, Vacuolar protein sorting-associating protein 4B
, vacuolar protein sorting factor 4B-like
, cell migration-inducing 1
, cell migration-inducing gene 1 protein
, suppressor of K(+) transport growth defect 1
, suppressor of K+ transport defect 1