Browse our 4-Hydroxy-2-Oxoglutarate Aldolase 1 Proteins (HOGA1)

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4-Hydroxy-2-Oxoglutarate Aldolase 1 Proteins (HOGA1)
On www.antibodies-online.com are 4 4-Hydroxy-2-Oxoglutarate Aldolase 1 (HOGA1) Proteins from 2 different suppliers available. Additionally we are shipping 4-Hydroxy-2-Oxoglutarate Aldolase 1 Kits (8) and and many more products for this protein. A total of 14 4-Hydroxy-2-Oxoglutarate Aldolase 1 products are currently listed.
Synonyms:
0610010D20Rik, C10orf65, DHDPS2, Dhdpsl, HP3, Npl2
list all proteins Gene Name GeneID UniProt
HOGA1 112817 Q86XE5
HOGA1 67432 Q9DCU9
HOGA1 506001 Q0P5I5

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4-Hydroxy-2-Oxoglutarate Aldolase 1 Proteins (HOGA1) by Origin

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More Proteins for 4-Hydroxy-2-Oxoglutarate Aldolase 1 Interaction Partners

Human 4-Hydroxy-2-Oxoglutarate Aldolase 1 (HOGA1) interaction partners

  1. Results show that HOGA1 harboring mutations found in primary hyperoxaluria is thermally unstable and targeted for proteolytic degradation leading to an absolute loss of function.

  2. Among the seven patients identified with HOGA1 mutations the median onset of clinical symptoms was 1.8 years. Five patients initially presented with urolithiasis, and two other patients presented with urinary tract infection.

  3. Our results strongly suggest HOGA1 as a major cause of PH, indicate a greater genetic heterogeneity of hyperoxaluria, and point to a favorable outcome of type III in the context of PH despite incomplete or absent biochemical remission

  4. Two crystal forms of DHDPSL were obtained, both of which diffracted X-rays to approximately 2.0 A resolution

  5. hHOGA utilizes a type I aldolase reaction mechanism, but employs novel residue interactions for substrate binding

  6. Detection of HOGA1 variants in idiopathic calcium oxalate urolithiasis also suggests HOGA1 may be a predisposing factor for this condition

  7. DHDPSL is the gene encoding 4-hydroxy-2-oxoglutarate aldolase, catalyzing the final step in the metabolic pathway of hydroxyproline.

Cow (Bovine) 4-Hydroxy-2-Oxoglutarate Aldolase 1 (HOGA1) interaction partners

  1. Native HOGA (show OAT Proteins) was purified from bovine kidney using a novel microtitration protocol to obtain diffraction-quality crystals.

4-Hydroxy-2-Oxoglutarate Aldolase 1 (HOGA1) Protein Profile

Protein Summary

The authors of PMID searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with 4-Hydroxy-2-Oxoglutarate Aldolase 1 (HOGA1)

  • 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1)
  • 4-hydroxy-2-oxoglutarate aldolase 1 (Hoga1)
  • 0610010D20Rik protein
  • C10orf65 protein
  • DHDPS2 protein
  • Dhdpsl protein
  • HP3 protein
  • Npl2 protein

Protein level used designations for HOGA1

DHDPS-like protein , N-acetylneuraminate pyruvate lyase 2 (putative) , dihydrodipicolinate synthase-like, mitochondrial , dihydrodipicolinate synthetase homolog 2 , probable 2-keto-4-hydroxyglutarate aldolase , probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial , probable KHG-aldolase , protein 569272

GENE ID SPECIES
112817 Homo sapiens
506001 Bos taurus
67432 Mus musculus
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