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these data suggest that the activation of DGKzeta downstream of antigen recognition provides a mechanism that ensures the activation of PA-dependent signaling as a direct result of the strength of TCR-dependent DAG mobilization.
We propose that enzymes that negatively regulate distal activating receptor signaling pathways such as DGKzeta represent novel targets for augmenting the therapeutic potential of NK cells.
Downregulation of DGKzeta might be one factor predisposing a person to osteolytic bone destruction in pathological conditions.
this is the first report implicating M-CSF/DGKzeta/DAG axis as a critical regulator of bone homeostasis via its actions on OC differentiation and c-Fos expression.
another possible involvement of DGKzeta in the regulation of secretion of the terminal tubule cells, as well as its functional significance of its nuclear localization in the submandibular ganglion cells is discussed
This study demonstrated that Diacylglycerol Kinase zeta with Protein Kinase (show CDK7 Proteins) Calpha (show PRKACA Proteins) Is Required for Cerebellar Long-Term Depression
The results suggest that DGKzeta cytoplasmic translocation in neurons under hypoxic stress is regulated by some mechanism which differs from that mediated by NAP1 (show ABI1 Proteins)-like proteins.
This study shows that DGKzeta knockdown facilitates degradation of IkappaB, followed by nuclear translocation of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.
DGKzeta regulates the development of natural Treg cells by limiting the extent of activation of the ERK (show EPHB2 Proteins) and c-Rel (show NFkBP65 Proteins) signaling pathways.
The zeta isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.
DGKzeta knockdown engenders enhancement of NF-kappaB (show NFKB1 Proteins) pathway in response to TNF-alpha (show TNF Proteins). [review]
This study shows that DGKzeta knockdown facilitates degradation of IkappaB, followed by nuclear translocation of NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) subunit.
Elevated DGKzeta expression contributes to increased Rho GTPase (show RACGAP1 Proteins) activation and the enhanced motility of metastatic cancer cells.
Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA).
DGK (show DGKB Proteins) regulates melanogenesis via modulation of the posttranslational processing of tyrosinase (show TYR Proteins), which may be related with the protein degradation machinery.
DGK-zeta translocated rapidly to the plasma membrane at early stages of immunological synapse (IS) formation independent of enzyme activity; study highlights a DGKzeta-specific function for local diacylglycerol metabolism at the IS and offers new clues to its mode of regulation
Antigen-specific CD8 (show CD8A Proteins)-positive T cells from DGKzeta-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK (show DGKB Proteins)-deficient memory CD8 (show CD8A Proteins)+ T cells exhibit impaired expansion.
Nucleosome assembly protein (NAP) 1-like 1 (NAP1L1 (show NAP1L1 Proteins)) and NAP1 (show IL8 Proteins)-like 4 (NAP1L4 (show NAP1L4 Proteins)) are identified as novel DGKzeta binding partners.
PKC alpha (show PKCa Proteins) phosphorylates diacylglycerol kinase zeta in cells, and this phosphorylation inhibits its kinase activity to remove cellular diacylglycerol, thereby affecting cell growth.
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified.
diacylglycerol kinase zeta
, diacylglycerol kinase, zeta 104kDa
, diacylglycerol kinase, zeta
, DAG kinase zeta
, diglyceride kinase zeta
, 104 kDa diacylglycerol kinase