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On normal salt diet, renal CuZnSOD (show SOD1 Proteins) and ECSOD (show SOD3 Proteins) proteins were similar but renal MnSOD (show SOD2 Proteins) was lower in hGRK4g486V than Non-T mice and remained low on high salt diet. hGRK4gammawild-type mice were normotensive and hGRK4g142V mice were hypertensive but both were salt-resistant and in normal redox balance. Chronic tempol treatment partially prevented the salt-sensitivity of hGRK4g486V mice.
A novel function of GRK4 on triggering a p53 (show TP53 Proteins)-independent cellular senescence, which involves an intricate signaling network.
the association between GRK4(142V) and a larger decrease in blood pressure with angiotensin receptor blockers in hypertensive patients.
Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215-2.745, P=0.004) but not in East Asians and Africans. [meta-analysis]
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (show NMUR1 Proteins) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C (show CLEC2G Proteins)-tail responsible for this GRK function.
hGRK4gamma(142V) phosphorylates histone deacetylase (show HDAC1 Proteins) type 1 and promotes its nuclear export to the cytoplasm, resulting in increased AT1R (show AGTR1 Proteins) expression and greater pressor response to angiotensin II.
A high sodium intake markedly increased the obesity risk in variants of GRK4 A486V regardless of sex amongst Korean children.
The C-terminal region of FMRP (show FMR1 Proteins) interacts with a domain of GRK4 mRNA that is folded in four stem loops.
GRK4alpha is more similar to GRK2 (show ADRBK1 Proteins) than GRK6 (show GRK6 Proteins). A fully ordered kinase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, including the alphaB helix, alphaD helix, and the P-loop
GRK4 genetic polymorphism plays an important role in the regulation of hypertension.
The role of GRK2 (show ADRBK1 Proteins) in chronic ET-1 (show EDN1 Proteins)-induced insulin (show INS Proteins) resistance was investigated.
GRK2 (show ADRBK1 Proteins) inhibits WNT (show WNT2 Proteins) signaling in osteoblasts
AMPK can function outside of its canonical nutrient-sensing role in specific developmental contexts.
The significance of these findings is that AMPK is important in the regulation of glucagon (show GCG Proteins) signaling, suggesting that the organization of metabolic networks is highly conserved and that AMPK plays a prominent role in these networks.
Loss of AMPK activity exacerbates neuronal loss and associated phenotypes in parkin (show PARK2 Proteins) and LRRK transgenic flies.
Data suggest that that an Sgt1 (show SUGT1 Proteins)/Hsp90 (show HSP90 Proteins)-LKB1 (show STK11 Proteins)-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.
AMPK gamma and alpha mutants altered lipid metabolism and showed persistent starvation behaviors.
AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut (show GUSB Proteins)
These results raise the possibility that muscle is one of major tissues in which AMPK plays a critical role on longevity and stress resistance.
activated by AMP (show AMPH Proteins) in cell-free assays and by stresses that deplete ATP; the phosphorylated DmAMPK alpha subunit (show POLG Proteins) was mainly detected in the nucleus
results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures
LKB1 (show STK11 Proteins) and AMPK have roles in cell polarity and division [review]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.
, G protein-coupled receptor kinase 2, groucho gene related
, g protein-coupled receptor kinase GRK4
, 5'monophosphate-activated kinase
, AMP-activated kinase
, AMP-activated protein kinase
, AMP-dependent kinase
, G protein-coupled receptor kinase 4
, SNF/AMP-activated protein S/T kinase gamma subunit
, adenosine monophosphate-activated protein kinase
, G-protein-coupled receptor kinase 2-like