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This study reveals how RGS (show PITX2 Proteins) proteins modulate Galphai2 (show GNAI2 Proteins) signaling to facilitate thymocyte egress and T cell trafficking.
Findings indicate that regulator of G-protein signaling 16 (RGS16) plays an important role in platelet function by modulating CXCL12 (show CXCL12 Proteins)-dependent platelet activation.
The authors confirmed the role of Gde1 in NAFLD by in vivo hepatic over-expression and shRNA knockdown studies.
RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-mediated pulmonary inflammation.
Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm.
RGS16 provides a signaling mechanism for glucose production to inhibit GPCR-stimulated fatty acid oxidation in hepatocytes
The present study suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s).
findings designate GroPSer as a previously unappreciated reservoir for free serine in the nervous system and suggest that GDE1 (show GDE1 Proteins), through recycling serine from GroPSer, may impact D-serine-dependent neural signaling processes in vivo
Rgs16 and Rgs8 (show RGS8 Proteins) are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults.
Data show that knockdown of TNFR (show TNFRSF1A Proteins)-associated factor 6 or NF-kappaB (show NFKB1 Proteins) activator 1 in 70Z/3 pre-B cells led to decreased Rgs16 expression, indicating that both of these two genes are involved in IL-17 (show IL17A Proteins)-mediated activation of NF-kappaB (show NFKB1 Proteins) signaling in B cells.
The data establish miR (show MLXIP Proteins)-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 (show CXCR4 Proteins) signaling by inhibition of RGS16.
suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16
these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells.
Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.
cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 (show KDM1A Proteins) and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy.
Missense mutations in RGS16 gene is associated with breast cancer.
RGS16 and FosB (show FOSB Proteins) are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival
Increased RGS16 levels are associated with colorectal cancer.
Src (show SRC Proteins) mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability.
results suggest that palmitoylation of a Cys residue in the regulator of G protein signaling(RGS) box is critical for RGS16 and RGS4 GAPase activating protein activity and their ability to regulate G protein signaling in mammalian cells
Facilitated degradation of the RGS16 by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins) mRNA transcripts.
The role of RGS16 in porcine circovirus infections via its binding with a nonstructural protein encoded by open reading frame 3 is reported.
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.
regulator of G-protein signaling 16
, regulators of G protein signaling XRGSI
, regulator of G-protein signalling 16
, Regulator of G-protein signaling 16
, membrane interacting protein of RGS16
, membrane-interacting protein of RGS16
, retinal-specific RGS
, retinally abundant regulator of G-protein signaling