Browse our RXFP1 Proteins (RXFP1)

Full name:
Relaxin/insulin-Like Family Peptide Receptor 1 Proteins (RXFP1)
On are 10 Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1) Proteins from 4 different suppliers available. Additionally we are shipping RXFP1 Antibodies (78) and RXFP1 Kits (25) and many more products for this protein. A total of 116 RXFP1 products are currently listed.
Gm1018, Lgr7, RXFP2, RXFPR1
list all proteins Gene Name GeneID UniProt
RXFP1 59350 Q9HBX9
RXFP1 381489 Q6R6I7
Rat RXFP1 RXFP1 295144 Q6R6I6

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More Proteins for RXFP1 Interaction Partners

Zebrafish Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1) interaction partners

  1. The rxfp1 expression pattern in Danio rerio embryos is very similar to that reported in the adult mammalian brain, suggesting a pivotal role of this receptor in the neurophysiology processes already at very early developmental stages.

Human Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1) interaction partners

  1. Binding of relaxin to RXFP1 recruits G proteins with subsequent activation of adenylyl cyclase and elevation of cAMP.

  2. The decreased expression of the endometrial RLX (show RLN1 Proteins) receptor in women with implantation failures, both in vitro fertilization failure and recurrent pregnancy loss, suggests that RLX (show RLN1 Proteins) may play a crucial role in the structural and functional changes of the endometrium during the window of implantation.

  3. Hormone receptor (show NR4A1 Proteins) expression was concentrated in the fibroblasts, and RXFP1 was also evident in blood vessels and nerves

  4. The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 has been deciphered.

  5. RXFP1 gene expression was dysregulated in the anterior cingulate of bipolar patients.

  6. H2 relaxin amide is fully active at the relaxin receptor RXFP1 and thus dimerization is not required for biological activity.

  7. Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability.

  8. Using cells stably expressing RXFP1, we found that relaxin regulation of PPARgamma activity requires accumulation of cAMP and subsequent activation of cAMP-dependent protein kinase (PKA).

  9. RXFP-1 receptors are present at the ligament, cartilage, and synovium of the TM joint, indicating that it is a potential target for relaxin. This suggests that circulating relaxin may impact joint stability.

  10. To create a tool to investigate the low-affinity interaction, a protein scaffold system displaying exoloops 1 and 2 from RXFP1 was designed.

Mouse (Murine) Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1) interaction partners

  1. No differences were found in RXFP1 expression related to aging.

  2. Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus.

  3. relaxin/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy

  4. Rxfp1, Rxfp2 (show RXFP2 Proteins), and Nr3c1 (show NR3C1 Proteins) mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.

  5. maternal exposure to simazine causes disturbed relaxin signaling pathway and testicular dysfunction

  6. H3 relaxin exerts antifibrotic actions via RXFP1 receptor

  7. The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 (show BTG2 Proteins) tumors.

  8. Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY (show PCDH11Y Proteins) in regulating increased canonical Wnt (show WNT2 Proteins) signaling in prostate cancer.

  9. neither Insl3 (show INSL3 Proteins) nor Lgr8 (show RXFP2 Proteins) contribute to the RLN (show RLN1 Proteins) signaling pathway; Insl3 (show INSL3 Proteins)/Lgr8 (show RXFP2 Proteins) and Rln1 (show RLN1 Proteins)/Lgr7 actions do not overlap in vivo

  10. mouse and rat LGR7 are the relaxin receptors in these species

RXFP1 Protein Profile

Protein Summary

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with RXFP1

  • relaxin/insulin-like family peptide receptor 1 (RXFP1)
  • relaxin/insulin-like family peptide receptor 1 (LOC100222591)
  • relaxin/insulin-like family peptide receptor 1 (rxfp1)
  • relaxin/insulin-like family peptide receptor 1 (Rxfp1)
  • relaxin/insulin-like family peptide receptor 1 (LOC100345713)
  • Gm1018 protein
  • Lgr7 protein
  • RXFP2 protein
  • RXFPR1 protein

Protein level used designations for RXFP1

leucine-rich repeat-containing G protein-coupled receptor 7 , relaxin/insulin-like family peptide receptor 1 , relaxin receptor 1-like , relaxin receptor 1 , leucine-rich repeat-containing 7 , leucine-rich repeat-containing G-protein coupled receptor 7 , relaxin family peptide receptor 1 , relaxin/insulin-like family peptide receptor 2

461572 Pan troglodytes
701107 Macaca mulatta
100222591 Taeniopygia guttata
100483514 Ailuropoda melanoleuca
100494807 Xenopus (Silurana) tropicalis
100498669 Danio rerio
100548436 Meleagris gallopavo
100562228 Anolis carolinensis
100591035 Nomascus leucogenys
59350 Homo sapiens
381489 Mus musculus
295144 Rattus norvegicus
100345713 Oryctolagus cuniculus
100721183 Cavia porcellus
100127453 Sus scrofa
475479 Canis lupus familiaris
532277 Bos taurus
422415 Gallus gallus
101107224 Ovis aries
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