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The expression status of Pim-3 mRNA was significantly associated with pathological parameters such as pre-surgery prostate specific antigen, Gleason score, pathological stage, and lymphoid metastasis.
Pim-3 expression was inversely correlated with that of miR (show MLXIP ELISA Kits)-377.
SSRP1 (show SSRP1 ELISA Kits)/Ets-1 (show ETS1 ELISA Kits)/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel.
Pim-3 expression showed a positive correlation with tumor cell differentiation.
Pim-3 has a role in human pancreatic cancer cell survival against radiation
A high percentage of urothelial carcinomas express Pim (show PIM1 ELISA Kits) kinases. Pim (show PIM1 ELISA Kits) expression differs in NILG, NIHG, and IHG lesions.
MicroRNA506 participates in pancreatic cancer pathogenesis by targeting PIM3
Pim-3 kinase enhances growth and metastatic properties of prostate cancer xenografts. PC-3 (show PCSK1 ELISA Kits) prostate cancer cells overexpressing either Pim-1 (show PIM1 ELISA Kits) or Pim-3 kinases form larger xenograft tumors than the parental PC-3 (show PCSK1 ELISA Kits) cells.
Knockdown of Pim-3 by specific shRNA slowed decreased proliferation, induced cell cycle arrest in the G0/G1 phase, and increased apoptosis in glioblastoma cells.
PIM3 expression is higher in ovarian cancer than in normal ovarian tissue. Upregulation of PIM3 promotes proliferation and migration of ovarian cancer cells.
Loss of PIM3 is associated with abnormal hematopoietic phenotypes.
investigation of physiological role of Pim3 in beta-cell function: regulates glucose-stimulated insulin (show INS ELISA Kits) secretion; limits ERK (show EPHB2 ELISA Kits) signaling; interacts with SOCS6 (show SOCS6 ELISA Kits); Pim3 localized to beta-cell; Pim3 knockout mice display increased glucose tolerance
Pim-3 has an important role in modulating c-Myc (show MYC ELISA Kits) and PGC-1alpha (show PPARGC1A ELISA Kits) protein levels and cell growth
All three Pim (show PIM1 ELISA Kits) kinase family members predominantly phosphorylate Bad on Ser112 and in addition are capable of phosphorylating Bad on multiple sites associated with the inhibition of the pro-apoptotic function of Bad in HEK (show EPHA3 ELISA Kits)-293 cells
Pim-3 kinase has a novel role in the control of self-renewal of embryonic stem cells.
Pim-3 is expressed in endothelial cells and promotes vascular tube formation.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis.
serine/threonine protein kinase pim-3
, non-specific serine/threonine protein kinase
, serine/threonine-protein kinase pim-3
, serine/threonine kinase Pim-3
, kinase induced by depolarization
, protein kinase Kid-1
, proviral integration site 3
, serine threonine kinase pim3
, KID-1/kinase induced by depolarization