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anti-Mouse (Murine) STXBP5L Antibodies:
anti-Rat (Rattus) STXBP5L Antibodies:
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Mouse (Murine) Polyclonal STXBP5L Primary Antibody for WB - ABIN2690538
Geerts, Plomp, Koopmans, Loos, van der Pijl, van der Valk, Verhage, Groffen: Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates. in Brain structure & function 2015
Data indicate that bidirectional moving tomosyn-1 (Stxbp5 (show STXBP5 Antibodies)) and tomosyn-2 (Stxbp5l) puncta were observed.
tomosyn-2 supports motor performance by regulation of transmitter release willingness to sustain synaptic strength during high-frequency transmission, which makes this gene a candidate for involvement in neuromuscular disorders.
Data indicate that glucose induces phosphorylation, ubiquitination, and degradation of tomosyn-2.
these findings suggest that tomosyn-2 is a key negative regulator of insulin (show INS Antibodies) secretion.
A homozygous nonsynonymous mutation in STXBP5L (c.3127G>A, p.Val1043Ile [CCDS43137.1]) was implicated in an infantile-onset neurodegenerative disorder manifesting a predominant sensorimotor axonal neuropathy, optic atrophy and cognitive deficit.
In skin aging rs322458, was in linkage disequilibrium (LD) with intronic single nucleotide polymorphisms of the STXBP5L gene, which is expressed in the skin.
May play a role in vesicle trafficking and exocytosis (Potential).
insulin level locus 1
, lethal(2) giant larvae protein homolog 4
, syntaxin-binding protein 5-like
, tomosyn 2