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Browse our UCP2 Proteins (UCP2)

Full name:
Uncoupling Protein 2 (Mitochondrial, Proton Carrier) Proteins (UCP2)
On are 9 Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) Proteins from 5 different suppliers available. Additionally we are shipping UCP2 Antibodies (132) and UCP2 Kits (27) and many more products for this protein. A total of 175 UCP2 products are currently listed.
ATUCP2, BMIQ4, cb74, DKFZp470P1633, K19M22.21, K19M22_21, MGC53319, MGC75881, Slc25a8, ucp2, UCPH, uncoupling protein 2
list all proteins Gene Name GeneID UniProt
UCP2 7351 P55851
UCP2 22228 P70406
UCP2 54315 P56500

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Zebrafish Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.

Human Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. UCP2 has an apoptotic effect in beta cells via regulation of the intrinsic pathway of apoptosis in brain dead organ donors.

  2. genetic association studies in population in Brazil: Data suggest that two SNPs in UCP2 (rs660339, Ala55Val; rs659366, -866G>A) are associated with ability of patients to comply with dietary restrictions follow bariatric surgery for morbid obesity; thus, UCP2 may be involved in appetite regulation and/or satiety response.

  3. The 'AA' genotype of UCP2 promoter gene polymorphism G to A at - 866 position revealed 12.39 folds risk for presbycusis.

  4. Estrogens may increase mitochondrial reactive oxygen species production by repressing uncoupling proteins including UCP2.

  5. UCP2 as a selective modulator of single channel MCU (show MCU Proteins) dependent mitochondrial Ca2 (show CA2 Proteins)+ inward current.

  6. GTPBP3 (show GTPBP3 Proteins) plays a role in the regulation of UCP2 protein through AMPK (show PRKAA1 Proteins) signaling.

  7. We conclude that UCP2 neither mediates palmitate-induced mitochondrial ROS (show ROS1 Proteins) generation and the associated cell loss, nor protects against these deleterious effects. Instead, UCP2 dampens palmitoleate protection against palmitate toxicity.

  8. UCP2 is expressed in human cumulus cells.

  9. Higher UCP2 expression corresponded with a poorer prognosis in breast cancer patients.

  10. Data reported here suggest that the UCP2 -866A/55Val/Ins (show INS Proteins) haplotype is associated with an increased risk for DKD and with a lower eGFR (show EGFR Proteins) in T2DM patients

Mouse (Murine) Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. Ucp2 affects glutathione metabolism by regulating hepatic efflux of glutathione. Nrf2 (show NFE2L2 Proteins) deficiency may not aggravate oxidative stress in Ucp2-deficient mice.

  2. Induction of autophagy by SCFAs required PPARgamma (show PPARG Proteins) stimulation of Uncoupling Protein 2 (UCP2) expression that was associated with reduced intracellular ATP levels and activation of PRKAA1/AMPK (show PRKAA1 Proteins) (protein kinase (show CDK7 Proteins), AMP (show TMPRSS5 Proteins)-activated, alpha 1 catalytic subunit). In addition, elimination of gut (show GUSB Proteins) flora by chronic antibiotic treatment diminished basal hepatic autophagy in mice suggesting that gut (show GUSB Proteins) microbiota can regulate hepatic auto...

  3. UCP2 induces protective effects on ROS (show ROS1 Proteins) and ATP levels during aging. Additionally, the results suggest an imbalance in hematopoiesis because of the lack of UCP2.

  4. Intriguingly, on the molecular level this acceleration in aging predominantly is accompanied by increased levels of circulating IGF-1 (show IGF1 Proteins) in Ucp2(-/-) mice, hinting at a crosstalk between UCP2 and the classical Insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) signaling aging pathway.

  5. PPARbeta (show PPARD Proteins)/PPARgamma (show PPARG Proteins) activation restored the LPS (show TLR4 Proteins)-induced endothelial dysfunction by upregulation of UCP2, with the subsequent alleviation of ER stress and NADPH oxidase (show NOX1 Proteins) activity, thus reducing intracellular reactive oxygen species production and increasing nitric oxide bioavailability.

  6. Apart from their slower growth, pancreatic stellate cells of UCP2-/- mice displayed no functional abnormalities.

  7. In the brains of UCP2-knockout mice, there was a decrease in glutamate, glutamine and GABA.

  8. Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue.

  9. Increased expression of UCP2 significantly reduced apoptosis during the critical developmental period resulting in elevated numbers of retinal ganglion cells in the adult.

  10. Study shows that mitochondrial location controlled by UCP2 is relevant for adaptive responses of neurons in cortical and hippocampal neurons and are relevant to perinatal hypoxia-triggered circuit adaptations

Pig (Porcine) Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.

  2. Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3, showing that UCPs have conservation and genetic reliability.

  3. The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 expression in selected muscles.

Cow (Bovine) Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (show UCP1 Proteins) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.

  2. A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Proteins)) in Angus steers selected to have high or low RFI (show RNF34 Proteins) is presented.

  3. These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.

UCP2 Protein Profile

Protein Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.

Alternative names and synonyms associated with UCP2

  • mitochondrial uncoupling protein 2 (PTRG_09289)
  • uncoupling protein 2 (mitochondrial, proton carrier) (UCP2)
  • mitochondrial uncoupling protein 2 (LOC100282746)
  • uncoupling protein 2 (ucp2)
  • uncoupling protein 2 (mitochondrial, proton carrier) (TEgg068n20.1)
  • uncoupling protein 2 (UCP2)
  • uncoupling protein 2 (LOC100534553)
  • uncoupling protein 2 (mitochondrial, proton carrier) (Ucp2)
  • ATUCP2 protein
  • BMIQ4 protein
  • cb74 protein
  • DKFZp470P1633 protein
  • K19M22.21 protein
  • K19M22_21 protein
  • MGC53319 protein
  • MGC75881 protein
  • Slc25a8 protein
  • ucp2 protein
  • UCPH protein
  • uncoupling protein 2 protein

Protein level used designations for UCP2

mitochondrial uncoupling protein 2 , uncoupling protein 2 (mitochondrial, proton carrier) , Mitochondrial uncoupling protein 2 , uncoupling protein 2 , UCP 2 , solute carrier family 25 member 8 , zUCP2 , UCPH , uncoupling protein 2, mitochondrial , uncoupling protein homolog , Uncoupling protein 2, mitochondrial

6347579 Pyrenophora tritici-repentis Pt-1C-BFP
100173815 Pongo abelii
100282746 Zea mays
379915 Xenopus laevis
394786 Xenopus (Silurana) tropicalis
555812 Danio rerio
574198 Macaca mulatta
836014 Arabidopsis thaliana
100534553 Oreochromis niloticus
7351 Homo sapiens
22228 Mus musculus
397549 Sus scrofa
54315 Rattus norvegicus
281562 Bos taurus
403576 Canis lupus familiaris
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