Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.
The lack of association with ECG derived QTd and UCP2 DD may suggest that gene-related QRS (show QARS Proteins) duration prolongation is independent of cardiac hypertrophy.
Cellular feedback regulation may occur between UCP2/UCP3 and ACE (show ACE Proteins). Cellular UCP (show UCP1 Proteins) regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism.
Study reports that insulin (show INS Proteins) resistance-related gene polymorphisms effects colorectal cancer (CRC (show CALR Proteins)) risk. The results showed that the gene polymorphism of ADIPOQ (show ADIPOQ Proteins) rs2241766 was associated with CRC (show CALR Proteins) risk. Furthermore, the interactions of ADIPOQ (show ADIPOQ Proteins) rs2241766, UCP2 rs659366, FABP2 (show FABP2 Proteins) rs1799883 and red meat consumption may contribute to the risk of CRC (show CALR Proteins).
the major components of metabolic syndrome in patients with non-alcoholic fatty liver disease (NAFLD) and nutritional intakes according to different genotype of uncoupling protein-2 (UCP2) -866G/A gene polymorphism in these patients, are reported.
Data suggest that UCP2 is an important regulator of mitochondrial redox status and lipid signaling, and that hydrogen peroxide might mediate UCP2's tumor promoting activity in skin.
our data revealed that COL1A1 (show COL1A1 Proteins), UCP2, and PRPF40A (show PRPF40A Proteins) are novel players implicated in the complex network of hypoxia response in non-small cell lung cancer
effects of UCP2 polymorphisms on the brain
genetic association studies on population in Brazil: Data suggest that a missense mutation (rs660339, Ala55Val) and an SNP (rs659366, -866G>A) in UCP2 are associated with weight loss in patients with morbid obesity following Roux-en-Y gastric bypass; individuals who carry T (CT+TT) and A (GA+AA) mutated alleles for Ala55Val and -866G>A, respectively, exhibit higher weight loss and fat-free (show VPS51 Proteins) mass loss.
Dominant UCP2 mutations are a more important cause of congenital hyperinsulinism than has been recognized and that affected individuals are markedly hypersensitive to glucose-induced hypoglycemia.
UCP2 has an apoptotic effect in beta cells via regulation of the intrinsic pathway of apoptosis in brain dead organ donors.
UCP-2 prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E (show APOE Proteins)-knockout mice via antioxidant and antiapoptotic activities.
This study demonstrating a FABP4 (show FABP4 Proteins)-UCP2 axis with the potential to modulate the microglial inflammatory response.
The miR (show MLXIP Proteins)-133a-UCP2 pathway participates in inflammatory bowel disease (IBD) by altering downstream inflammation, oxidative stress and markers of energy metabolism, which provides novel clues and potential therapeutic targets for IBD.
PPARgamma (show PPARG Proteins) inhibited PDGF (show PDGFA Proteins)-BB-induced ROS (show ROS1 Proteins) in VSMCs by upregulating UCP2 expression.
these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression.
Ucp2 affects glutathione metabolism by regulating hepatic efflux of glutathione. Nrf2 (show NFE2L2 Proteins) deficiency may not aggravate oxidative stress in Ucp2-deficient mice.
Induction of autophagy by SCFAs required PPARgamma (show PPARG Proteins) stimulation of Uncoupling Protein 2 (UCP2) expression that was associated with reduced intracellular ATP levels and activation of PRKAA1/AMPK (show PRKAA1 Proteins) (protein kinase (show CDK7 Proteins), AMP (show TMPRSS5 Proteins)-activated, alpha 1 catalytic subunit). In addition, elimination of gut (show GUSB Proteins) flora by chronic antibiotic treatment diminished basal hepatic autophagy in mice suggesting that gut (show GUSB Proteins) microbiota can regulate hepatic auto...
UCP2 induces protective effects on ROS (show ROS1 Proteins) and ATP levels during aging. Additionally, the results suggest an imbalance in hematopoiesis because of the lack of UCP2.
Intriguingly, on the molecular level this acceleration in aging predominantly is accompanied by increased levels of circulating IGF-1 (show IGF1 Proteins) in Ucp2(-/-) mice, hinting at a crosstalk between UCP2 and the classical Insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) signaling aging pathway.
PPARbeta (show PPARD Proteins)/PPARgamma (show PPARG Proteins) activation restored the LPS (show TLR4 Proteins)-induced endothelial dysfunction by upregulation of UCP2, with the subsequent alleviation of ER stress and NADPH oxidase (show NOX1 Proteins) activity, thus reducing intracellular reactive oxygen species production and increasing nitric oxide bioavailability.
Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.
Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3, showing that UCPs have conservation and genetic reliability.
The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 expression in selected muscles.
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (show UCP1 Proteins) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Proteins)) in Angus steers selected to have high or low RFI (show RNF34 Proteins) is presented.
These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
mitochondrial uncoupling protein 2
, uncoupling protein 2 (mitochondrial, proton carrier)
, Mitochondrial uncoupling protein 2
, uncoupling protein 2
, UCP 2
, solute carrier family 25 member 8
, uncoupling protein 2, mitochondrial
, uncoupling protein homolog
, Uncoupling protein 2, mitochondrial